公开(公告)号：US20090269409A1

公开(公告)日：2009-10-29

申请号：US12428818

申请日：2009-04-23

Applicant: Mukesh Kumar Garg ,  Parag Prakash Borde ,  Pradeep Kumar Gupta

Inventor： Mukesh Kumar Garg ,  Parag Prakash Borde ,  Pradeep Kumar Gupta

IPC: A61K9/14 ,  A61K31/4985

CPC classification number: A61K31/4985 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2866

Abstract: Pharmaceutical compositions comprising eszopiclone, including its pharmaceutically acceptable salts, hydrates, clathrates, solvates, polymorphs, and mixtures thereof. The invention also relates to processes for preparing the compositions and their methods of use.

Abstract translation: 药物组合物，其包含依佐匹克隆，包括其药学上可接受的盐，水合物，包合物，溶剂合物，多晶型物及其混合物。 本发明还涉及制备组合物及其使用方法的方法。

公开(公告)号：US08399677B2

公开(公告)日：2013-03-19

申请号：US12922906

申请日：2009-03-09

Applicant: Pradeep Kumar Gupta ,  Laxmi Manral ,  Kumaran Ganesan ,  Ramesh Chandra Malhotra ,  Krishnamurthy Sekhar

Inventor： Pradeep Kumar Gupta ,  Laxmi Manral ,  Kumaran Ganesan ,  Ramesh Chandra Malhotra ,  Krishnamurthy Sekhar

IPC: C07D211/56

CPC classification number: C07D211/58

Abstract: The invention provides a method for the preparation of fentanyl comprising: (a) reacting 4-piperidone hydrochloride monohydrate with aniline in presence of reducing environment to produce 4-anilinopiperidine (4-AP), (b) reacting the 4-AP as obtained from step (a) with phenethyl halide under reflux conditions in highly alkaline medium to give 4-anilino-N-phenethylpiperidine, and (c) converting the 4-anilino-N-phenethylpiperidine to fentanyl by reacting with propionyl chloride in presence of halogenated hydrocarbons, then isolating fentanyl by solvent extraction and purifying by crystallization from petroleum ether at a temperature ranging from 60-80° C.

Abstract translation: 本发明提供了一种制备芬太尼的方法，包括：（a）在还原环境存在下使4-哌啶酮盐酸盐一水合物与苯胺反应，生成4-苯胺基哌啶（4-AP），（b）使4-AP从 步骤（a）在高碱性介质中在回流条件下用苯乙基卤化物反应，得到4-苯胺基-N-苯乙基哌啶，和（c）通过与丙酰氯在卤代烃存在下反应将4-苯胺基-N-苯乙基哌啶转化成芬太尼， 然后通过溶剂萃取分离芬太尼，并在60-80℃的温度下从石油醚中结晶纯化。

公开(公告)号：US20110021781A1

公开(公告)日：2011-01-27

申请号：US12922906

申请日：2009-03-09

Applicant: Pradeep Kumar Gupta ,  Laxmi Manral ,  Kumaran Ganesan ,  Ramesh Chandra Malhotra ,  Krishnamurthy Sekhar

Inventor： Pradeep Kumar Gupta ,  Laxmi Manral ,  Kumaran Ganesan ,  Ramesh Chandra Malhotra ,  Krishnamurthy Sekhar

IPC: C07D211/58

CPC classification number: C07D211/58

Abstract: The invention provides a method for the preparation of fentanyl comprising: (a) reacting 4-piperidone hydrochloride (NPP) with aniline in presence of reducing environment to produce 4-anilinopiperidine (4-ANPP), (b) reacting the 4-ANPP as obtained from step (a) with phenethyl halide under reflux conditions in highly alkaline medium to give 4-anilino-N-phenethylpiperidine, and (c) converting the 4-anilino-N-phenethylpiperidine to fentanyl by reacting with propionyl chloride in presence of halogenated hydrocarbons, then isolating fentanyl by solvent extraction and purifying by crystallization from petroleum ether at a temperature ranging from 60-80° C.

Abstract translation: 本发明提供了一种制备芬太尼的方法，包括：（a）在还原环境存在下使4-哌啶酮盐酸盐（NPP）与苯胺反应以产生4-苯胺基哌啶（4-ANPP），（b）使4-ANPP作为 在高碱性介质中在回流条件下用步骤（a）得到步骤（a），得到4-苯胺基-N-苯乙基哌啶，和（c）通过与丙酰氯在卤化物存在下反应将4-苯胺基-N-苯乙基哌啶转化成芬太尼 烃，然后通过溶剂萃取分离芬太尼，并在60-80℃的温度下从石油醚中结晶纯化。

公开(公告)号：US07615672B2

公开(公告)日：2009-11-10

申请号：US11883155

申请日：2005-06-23

Applicant: Kumaran Ganesan ,  Ramesh Chandra Malhotra ,  Ambati Narasimha Rao ,  Pradeep Kumar Gupta ,  Asheesh Kumar Jain ,  Shri Prakash ,  Krishnamurthy Sekhar

Inventor： Kumaran Ganesan ,  Ramesh Chandra Malhotra ,  Ambati Narasimha Rao ,  Pradeep Kumar Gupta ,  Asheesh Kumar Jain ,  Shri Prakash ,  Krishnamurthy Sekhar

IPC: C07C1/207

CPC classification number: C07C1/22 ,  C07C45/68 ,  C07C9/22 ,  C07C49/04

Abstract: A process for the preparation of n-heneicosane is disclosed. The process comprises (a) reacting 2,4-alkaneanedione with 1-bromooctadecane in absolute ethanol in the presence of 18-crown-6 as catalyst to produce 2-heneicosanone; and (b) reducing said 2-heneicosanone using hydrazine hydrate and potassium hydroxide in ethylene glycol to obtain n-heneicosane.

Abstract translation: 公开了制备正二硅烷的方法。 该方法包括（a）在18-冠醚-6作为催化剂的存在下，将2,4-烷二酮与1-溴十八烷在无水乙醇中反应生成2-乙烯酮; 和（b）使用水合肼和氢氧化钾在乙二醇中还原所述2-己烯酮以获得正二十二烷。

公开(公告)号：US07502107B2

公开(公告)日：2009-03-10

申请号：US10569047

申请日：2003-08-22

Applicant: Samarendra Kumar Mohanty ,  Pradeep Kumar Gupta

Inventor： Samarendra Kumar Mohanty ,  Pradeep Kumar Gupta

IPC: G01J3/30

CPC classification number: G21K1/006

Abstract: A system and the method for transport of microscopic objects/particles involving the use of laser source operatively connected to a microscope objective which is adapted to generate optical focal spots on said particle(s) with asymmetric intensity profile in transverse plane followed by varying the said asymmetry of the gradient optical forces on the micron sized object/particles to thereby transport the microscopic object(s). The system and the method can be used to transport microscopic objects including i) transportation of cells and intra-cellular organelles, ii) acceleration of microscopic objects along any direction in a plane transverse to the direction of propagation of laser beam, iii) optical channeling of objects through a micro-capillary from one micro-well to another and transfer to another channel after desired processing, iv) sorting of microscopic objects, v) optical control of micro-machines, micro-fluidic devices etc.

Abstract translation: 涉及使用可操作地连接到显微镜物镜的激光源的微观物体/颗粒的传送系统和方法，该显微镜物镜适于在横向平面上产生具有不对称强度分布的所述颗粒上产生光学焦斑，随后改变所述 在微米尺寸的物体/颗粒上的梯度光学力的不对称性，从而传送微观物体。 该系统和方法可用于运输微观物体，包括i）细胞和细胞内细胞器的运输，ii）沿与激光束传播方向相反的平面中的任何方向的微观物体的加速，iii）光通道 的物体通过微毛细管从一个微孔到另一个微孔，并在所需的处理之后转移到另一个通道，iv）微观物体的分选，v）微机，微流体装置等的光学控制。