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公开(公告)号：US08535951B2
公开(公告)日：2013-09-17
申请号：US12531054
申请日：2008-03-13
Applicant: Ganga Prasad Rai , Gauri Shanker Agarwal , Samuel Merwyn Packia Raj , Krishnamurthy Sekhar , Ajay Kumar Sood , Ajay Singh Negi
Inventor： Ganga Prasad Rai , Gauri Shanker Agarwal , Samuel Merwyn Packia Raj , Krishnamurthy Sekhar , Ajay Kumar Sood , Ajay Singh Negi
IPC: G01N33/549
CPC classification number: G01N33/54313 , G01N33/54393 , G01N33/544 , G01N33/56916 , G01N2333/255 , Y02A50/59
Abstract: The present disclosure provides a reagent for detection of analyte in a sample and process of preparation of the reagent. The reagent comprises heparin and substrate coated with the analyte-counterpart. The analyte-counterpart of the reagent is capable of binding to said analyte. The present disclosure further provides a process for detection of an analyte in a sample by contacting said sample with said reagent and detecting formation of analyte-analyte counterpart complex. The present disclosure provides a kit for detection of an analyte in a sample.
Abstract translation: 本公开提供了用于检测样品中的分析物的试剂和试剂的制备方法。 试剂包含肝素和用分析物对应物涂覆的底物。 试剂的分析物对应物能够结合所述分析物。 本公开还提供了通过使所述样品与所述试剂接触并检测分析物 - 分析物对应物复合物的形成来检测样品中分析物的方法。 本公开提供了用于检测样品中的分析物的试剂盒。
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公开(公告)号：US20130052287A1
公开(公告)日：2013-02-28
申请号：US13400921
申请日：2012-02-21
Applicant: Mahabir Prashad KAUSHIK , Duraipandian Thavaselvam , Manisha Nivsarkar , Sanjay Kumar , Krishnamurthy Sekhar , Hemant Kumar Gogoi , Deba Koch
Inventor： Mahabir Prashad KAUSHIK , Duraipandian Thavaselvam , Manisha Nivsarkar , Sanjay Kumar , Krishnamurthy Sekhar , Hemant Kumar Gogoi , Deba Koch
CPC classification number: A61K36/53 , Y02A50/411
Abstract: The present invention relates to a novel bioactive water fraction obtained from the leaves of an herb named Gomphostema niveum commonly found in North Eastern part of India, and which is useful for inhibiting the growth of malarial parasite Plasmodium falciparum. The present invention also relates to a method for the extraction of said bioactive fraction. The present invention also provides methods for treatment of malaria using such bioactive water fractions and use of such bioactive water fractions for the treatment of malaria.
Abstract translation: 本发明涉及一种从印度东北部通常发现的名为Gomphostema niveum的草本叶获得的新型生物活性水分，其可用于抑制恶性疟原虫恶性疟原虫的生长。 本发明还涉及提取所述生物活性级分的方法。 本发明还提供了使用这种生物活性水部分治疗疟疾的方法以及使用这种生物活性水部分来治疗疟疾。
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公开(公告)号：US20100197781A1
公开(公告)日：2010-08-05
申请号：US11992934
申请日：2006-08-30
Applicant: Mahabir Prashad Kaushik , Duraipandian Thavaselvam , Manisha Nivsarkar , Badri Narayan Acharya , Subramaniam Prasanna , Krishnamurthy Sekhar
Inventor： Mahabir Prashad Kaushik , Duraipandian Thavaselvam , Manisha Nivsarkar , Badri Narayan Acharya , Subramaniam Prasanna , Krishnamurthy Sekhar
IPC: A61K31/34 , C07D307/02 , A61P33/06
CPC classification number: A61K36/53 , C07D307/32 , C07D307/33 , Y02A50/411
Abstract: The present invention provides an antimalarial compound 3-[2-(2-Hydroxymethyl-1, 4a, 5-trimethyl-7-oxo-1,2,3,4,4a, 7 8, 8a-octahydronaphthalen-1-yl)-ethyl]-5H-furan-2-one of the formula 1 given below or pharmaceutically acceptable derivatives thereof, isolated from Gomphostema niveum and also provides a method for the extraction thereof as well as methods for the treatment of malaria using said compound.
Abstract translation: 本发明提供抗疟药化合物3- [2-（2-羟甲基-1,2,4,5-五甲基-7-氧代-1,2,3,4,4a，7,8,8-八氢萘-1-基） - 乙基] -5H-呋喃-2-酮或其药学上可接受的衍生物，从Gomphostema niveum分离，并提供其提取方法以及使用所述化合物治疗疟疾的方法。
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公开(公告)号：US08282968B2
公开(公告)日：2012-10-09
申请号：US11992927
申请日：2006-08-30
Applicant: Mahabir Prashad Kaushik , Duraipandian Thavaselvam , Manisha Nivsarkar , Sanjay Kumar , Krishnamurthy Sekhar , Hemant Kumar Gogoi , Deba Koch
Inventor： Mahabir Prashad Kaushik , Duraipandian Thavaselvam , Manisha Nivsarkar , Sanjay Kumar , Krishnamurthy Sekhar , Hemant Kumar Gogoi , Deba Koch
IPC: A01N65/00
CPC classification number: A61K36/53 , Y02A50/411
Abstract: The present invention relates to a novel bioactive water fraction obtained from the leaves of an herb named Gomphostema niveum commonly found in North Eastern part of India, and which is useful for inhibiting the growth of malarial parasite Plasmodium falciparum. The present invention also relates to a method for the extraction of said bioactive fraction. The present invention also provides methods for treatment of malaria using such bioactive water fractions and use of such bioactive water fractions for the treatment of malaria.
Abstract translation: 本发明涉及一种从印度东北部通常发现的名为Gomphostema niveum的草本叶获得的新型生物活性水分，其可用于抑制恶性疟原虫恶性疟原虫的生长。 本发明还涉及提取所述生物活性级分的方法。 本发明还提供了使用这种生物活性水部分治疗疟疾的方法以及使用这种生物活性水部分来治疗疟疾。
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公开(公告)号：US20080274076A1
公开(公告)日：2008-11-06
申请号：US11884824
申请日：2005-06-23
Applicant: Shri Prakash , Murlidhar Jaywantrao Mendki , Kumaran Ganesan , Natarajan Gopalan , Ramesh Chandra Malhotra , Kshitij Chandel , Brahma Dutt Parashar , Rajagopalan Vijayaraghavan , Krishnamurthy Sekhar
Inventor： Shri Prakash , Murlidhar Jaywantrao Mendki , Kumaran Ganesan , Natarajan Gopalan , Ramesh Chandra Malhotra , Kshitij Chandel , Brahma Dutt Parashar , Rajagopalan Vijayaraghavan , Krishnamurthy Sekhar
CPC classification number: A01N27/00
Abstract: The present invention discloses a composition for use in luring Aedes aegypti mosquitoes to lay their eggs in a target site, which comprises of an effective amount n-heneicosane in a suitable organic solvent. The composition may also contain an effective amount of insecticide capable of killing the mosquito larvae soon after they hatch out of their eggs. measurement switch, a transformer (low voltage/medium voltage), a DC/AC inverter, a capacitor, a voltage dip detection circuit, and a control circuit.
Abstract translation: 本发明公开了一种用于诱捕埃及伊蚊的用于将其卵置于靶位的组合物，其包含有效量的正己烷在合适的有机溶剂中。 该组合物还可以含有有效量的杀虫剂，其能够在孵出卵后立即杀死蚊子幼虫。 测量开关，变压器（低压/中压），DC / AC逆变器，电容器，电压汲取检测电路和控制电路。
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Patent Agency Ranking
公开(公告)号：US09359237B2
公开(公告)日：2016-06-07
申请号：US12307872
申请日：2007-07-09
Applicant: Krishnamurthy Sekhar , Dev Vrat Kamboj , Lokendra Singh , Vichitra Kumar Gangwar , Arvind Tomar , Ramesh Chand Meena
Inventor： Krishnamurthy Sekhar , Dev Vrat Kamboj , Lokendra Singh , Vichitra Kumar Gangwar , Arvind Tomar , Ramesh Chand Meena
IPC: B01D21/00 , C02F1/20 , C02F1/76 , C02F3/00 , C02F9/00 , C02F11/00 , C02F3/12 , C02F11/14 , C02F103/00
CPC classification number: C02F3/1242 , B01D21/003 , C02F1/20 , C02F1/76 , C02F9/005 , C02F11/14 , C02F2103/005 , Y02W10/15
Abstract: A digester for degradation of human waste comprising a main tank having biochemical treatment compartment and chemical treatment compartment connected by connecting pipe as a passage for bio-chemically treated waste to chemical treatment compartment; the biochemical treatment compartment has at least one loosely fitted partitioned wall and at least one inlet to receive waste, at least one gas outlet and at least one waste drain pipe to remove sludge; the chemical treatment compartment has discharge means to discharge treated waste and excess of liquid, and float ball assembly to release chemical for chemical treatment.
Abstract translation: 一种用于人体废物降解的消化器，包括具有生物化学处理室和化学处理室的主罐，连接管通过生物化学处理的废物通向化学处理室; 所述生物化学处理室具有至少一个松散配合的分隔壁和至少一个入口以接收废物，至少一个气体出口和至少一个废物排放管以去除污泥; 化学处理室具有排出处理废物和过量液体的排放装置，以及浮球组件以释放用于化学处理的化学品。
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公开(公告)号：US20110021781A1
公开(公告)日：2011-01-27
申请号：US12922906
申请日：2009-03-09
Applicant: Pradeep Kumar Gupta , Laxmi Manral , Kumaran Ganesan , Ramesh Chandra Malhotra , Krishnamurthy Sekhar
Inventor： Pradeep Kumar Gupta , Laxmi Manral , Kumaran Ganesan , Ramesh Chandra Malhotra , Krishnamurthy Sekhar
IPC: C07D211/58
CPC classification number: C07D211/58
Abstract: The invention provides a method for the preparation of fentanyl comprising: (a) reacting 4-piperidone hydrochloride (NPP) with aniline in presence of reducing environment to produce 4-anilinopiperidine (4-ANPP), (b) reacting the 4-ANPP as obtained from step (a) with phenethyl halide under reflux conditions in highly alkaline medium to give 4-anilino-N-phenethylpiperidine, and (c) converting the 4-anilino-N-phenethylpiperidine to fentanyl by reacting with propionyl chloride in presence of halogenated hydrocarbons, then isolating fentanyl by solvent extraction and purifying by crystallization from petroleum ether at a temperature ranging from 60-80° C.
Abstract translation: 本发明提供了一种制备芬太尼的方法，包括：（a）在还原环境存在下使4-哌啶酮盐酸盐（NPP）与苯胺反应以产生4-苯胺基哌啶（4-ANPP），（b）使4-ANPP作为 在高碱性介质中在回流条件下用步骤（a）得到步骤（a），得到4-苯胺基-N-苯乙基哌啶，和（c）通过与丙酰氯在卤化物存在下反应将4-苯胺基-N-苯乙基哌啶转化成芬太尼 烃，然后通过溶剂萃取分离芬太尼，并在60-80℃的温度下从石油醚中结晶纯化。
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公开(公告)号：US20100203179A1
公开(公告)日：2010-08-12
申请号：US11992927
申请日：2006-08-30
Applicant: Mahabir Prashad Kaushik , Duraipandian Thavaselvam , Manisha Nivsarkar , Sanjay Kumar , Krishnamurthy Sekhar , Hemant Kumar Gogoi , Deba Koch
Inventor： Mahabir Prashad Kaushik , Duraipandian Thavaselvam , Manisha Nivsarkar , Sanjay Kumar , Krishnamurthy Sekhar , Hemant Kumar Gogoi , Deba Koch
CPC classification number: A61K36/53 , Y02A50/411
Abstract: The present invention relates to a novel bioactive water fraction obtained from the leaves of an herb named Gomphostema niveum commonly found in North Eastern part of India, and which is useful for inhibiting the growth of malarial parasite Plasmodium falciparum. The present invention also relates to a method for the extraction of said bioactive fraction. The present invention also provides methods for treatment of malaria using such bioactive water fractions and use of such bioactive water fractions for the treatment of malaria.
Abstract translation: 本发明涉及一种从印度东北部通常发现的名为Gomphostema niveum的草本叶获得的新型生物活性水分，其可用于抑制恶性疟原虫恶性疟原虫的生长。 本发明还涉及提取所述生物活性级分的方法。 本发明还提供了使用这种生物活性水部分治疗疟疾的方法以及使用这种生物活性水部分来治疗疟疾。
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公开(公告)号：US20100151485A1
公开(公告)日：2010-06-17
申请号：US12531054
申请日：2008-03-13
Applicant: Ganga Prasad Rai , Gauri Shanker Agarwal , Samuel Merwyn Packia Raj , Krishnamurthy sekhar , Ajay Kumar Sood
Inventor： Ganga Prasad Rai , Gauri Shanker Agarwal , Samuel Merwyn Packia Raj , Krishnamurthy sekhar , Ajay Kumar Sood
IPC: G01N33/53
CPC classification number: G01N33/54313 , G01N33/54393 , G01N33/544 , G01N33/56916 , G01N2333/255 , Y02A50/59
Abstract: The present disclosure provides a reagent for detection of analyte in a sample and process of preparation of the reagent. The reagent comprises heparin and substrate coated with the analyte-counterpart. The analyte-counterpart of the reagent is capable of binding to said analyte. The present disclosure further provides a process for detection of an analyte in a sample by contacting said sample with said reagent and detecting formation of analyte-analyte counterpart complex. The present disclosure provides a kit for detection of an analyte in a sample.
Abstract translation: 本公开提供了用于检测样品中的分析物的试剂和试剂的制备方法。 试剂包含肝素和用分析物对应物涂覆的底物。 试剂的分析物对应物能够结合所述分析物。 本公开还提供了通过使所述样品与所述试剂接触并检测分析物 - 分析物对应物复合物的形成来检测样品中分析物的方法。 本公开提供了用于检测样品中的分析物的试剂盒。
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公开(公告)号：US07615672B2
公开(公告)日：2009-11-10
申请号：US11883155
申请日：2005-06-23
Applicant: Kumaran Ganesan , Ramesh Chandra Malhotra , Ambati Narasimha Rao , Pradeep Kumar Gupta , Asheesh Kumar Jain , Shri Prakash , Krishnamurthy Sekhar
Inventor： Kumaran Ganesan , Ramesh Chandra Malhotra , Ambati Narasimha Rao , Pradeep Kumar Gupta , Asheesh Kumar Jain , Shri Prakash , Krishnamurthy Sekhar
IPC: C07C1/207
Abstract: A process for the preparation of n-heneicosane is disclosed. The process comprises (a) reacting 2,4-alkaneanedione with 1-bromooctadecane in absolute ethanol in the presence of 18-crown-6 as catalyst to produce 2-heneicosanone; and (b) reducing said 2-heneicosanone using hydrazine hydrate and potassium hydroxide in ethylene glycol to obtain n-heneicosane.
Abstract translation: 公开了制备正二硅烷的方法。 该方法包括（a）在18-冠醚-6作为催化剂的存在下，将2,4-烷二酮与1-溴十八烷在无水乙醇中反应生成2-乙烯酮; 和（b）使用水合肼和氢氧化钾在乙二醇中还原所述2-己烯酮以获得正二十二烷。
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