公开(公告)号：US20110263974A1

公开(公告)日：2011-10-27

申请号：US13094764

申请日：2011-04-26

申请人： Stephen M. Wiener ,  Robert F. Hoyt, JR. ,  John R. Deleonardis ,  Randall R. Clevenger ,  Robert J. Lutz ,  Douglas V. Christini ,  Brain Safer

发明人： Stephen M. Wiener ,  Robert F. Hoyt, JR. ,  John R. Deleonardis ,  Randall R. Clevenger ,  Robert J. Lutz ,  Douglas V. Christini ,  Brain Safer

IPC分类号： A61M5/14 ,  A61B6/00 ,  A61M5/00

CPC分类号： A61M25/1011 ,  A61B17/3417 ,  A61B2017/3425 ,  A61M25/02 ,  A61M25/04 ,  A61M2025/0233

摘要： Methods and devices are disclosed for selective delivery of therapeutic substances to specific histologic or microanatomic areas of organs. Introduction of the therapeutic substance into a hollow organ space (such as an hepatobiliary duct or the gallbladder lumen) at a controlled pressure, volume or rate allows the substance to reach a predetermined cellular layer (such as the ephithelium or sub-epithelial space). The volume or flow rate of the substance can be controlled so that the intralumenal pressure reaches a predetermined threshold level beyond which subsequent subepithelial delivery of the substance occurs. Alternatively, a lower pressure is selected that does not exceed the threshold level, so that delivery occurs substantially only to the epithelial layer. Such site specific delivery of therapeutic agents permits localized delivery of substances (for example to the interstitial tissue of an organ) in concentrations that may otherwise produce systemic toxicity. Occlusion of venous or lymphatic drainage from the organ can also help prevent systemic administration of therapeutic substances, and increase selective delivery to superficial epithelial cellular layers. Delivery of genetic vectors can also be better targeted to cells where gene expression is desired. The access device comprises a cannula with a wall piercing tracar within the lumen. Two axially spaced inflatable balloons engage the wall securing the cannula and sealing the puncture site. A catheter equipped with an occlusion balloon is guided through the cannula to the location where the therapeutic substance is to be delivered.

摘要翻译： 公开了用于将治疗物质选择性递送到器官的特定组织学或微解剖区域的方法和装置。 以受控的压力，体积或速率将治疗物质引入中空器官空间（例如肝胆管或胆囊腔）中允许物质到达预定的细胞层（例如上睑或上皮上皮空间）。 可以控制物质的体积或流速，使得腔内压力达到预定阈值水平，超过此阈值水平发生物质的后续上皮下递送。 或者，选择不超过阈值水平的较低压力，使得递送基本上仅发生在上皮层。 治疗剂的这种位点特异性递送允许以另外可能产生全身毒性的浓度局部递送物质（例如，器官的间质组织）。 从器官中静脉或淋巴引流的阻塞还可以帮助防止治疗物质的全身给药，并增加对表面上皮细胞层的选择性递送。 遗传载体的递送也可以更好地靶向需要基因表达的细胞。 进入装置包括在管腔内具有穿孔孔的套管。 两个轴向间隔开的可充气气囊与固定插管并密封穿刺部位的壁接合。 配备有闭塞气囊的导管通过套管被引导到治疗物质要被输送的位置。

公开(公告)号：US08409166B2

公开(公告)日：2013-04-02

申请号：US13094764

申请日：2011-04-26

申请人： Stephen M. Wiener ,  Robert F. Hoyt, Jr. ,  John R. Deleonardis ,  Randall R. Clevenger ,  Robert J. Lutz ,  Douglas V. Christini ,  Brian Safer

发明人： Stephen M. Wiener ,  Robert F. Hoyt, Jr. ,  John R. Deleonardis ,  Randall R. Clevenger ,  Robert J. Lutz ,  Douglas V. Christini ,  Brian Safer

IPC分类号： A61M31/00

CPC分类号： A61M25/1011 ,  A61B17/3417 ,  A61B2017/3425 ,  A61M25/02 ,  A61M25/04 ,  A61M2025/0233

摘要： Methods and devices are disclosed for selective delivery of therapeutic substances to specific histologic or microanatomic areas of organs. Introduction of the therapeutic substance into a hollow organ space (such as an hepatobiliary duct or the gallbladder lumen) at a controlled pressure, volume or rate allows the substance to reach a predetermined cellular layer (such as the ephithelium or sub-epithelial space). The volume or flow rate of the substance can be controlled so that the intralumenal pressure reaches a predetermined threshold level beyond which subsequent subepithelial delivery of the substance occurs. Alternatively, a lower pressure is selected that does not exceed the threshold level, so that delivery occurs substantially only to the epithelial layer. Such site specific delivery of therapeutic agents permits localized delivery of substances (for example to the interstitial tissue of an organ) in concentrations that may otherwise produce systemic toxicity. Occlusion of venous or lymphatic drainage from the organ can also help prevent systemic administration of therapeutic substances, and increase selective delivery to superficial epithelial cellular layers. Delivery of genetic vectors can also be better targeted to cells where gene expression is desired. The access device comprises a cannula with a wall piercing tracar within the lumen. Two axially spaced inflatable balloons engage the wall securing the cannula and sealing the puncture site. A catheter equipped with an occlusion balloon is guided through the cannula to the location where the therapeutic substance is to be delivered.

摘要翻译： 公开了用于将治疗物质选择性递送到器官的特定组织学或微解剖区域的方法和装置。 以受控的压力，体积或速率将治疗物质引入中空器官空间（例如肝胆管或胆囊腔）中允许物质到达预定的细胞层（例如上睑或上皮上皮空间）。 可以控制物质的体积或流速，使得腔内压力达到预定阈值水平，超过此阈值水平发生物质的后续上皮下递送。 或者，选择不超过阈值水平的较低压力，使得递送基本上仅发生在上皮层。 治疗剂的这种位点特异性递送允许以另外可能产生全身毒性的浓度局部递送物质（例如，器官的间质组织）。 从器官中静脉或淋巴引流的阻塞还可以帮助防止治疗物质的全身给药，并增加对表面上皮细胞层的选择性递送。 遗传载体的递送也可以更好地靶向需要基因表达的细胞。 进入装置包括在管腔内具有穿孔孔的套管。 两个轴向间隔开的可充气气囊与固定插管并密封穿刺部位的壁接合。 配备有闭塞气囊的导管通过套管被引导到治疗物质要被输送的位置。

公开(公告)号：US5134969A

公开(公告)日：1992-08-04

申请号：US594923

申请日：1990-10-10

申请人： Robert T. Mason ,  Robert F. Hoyt, Jr. ,  Lewis K. Pannell

发明人： Robert T. Mason ,  Robert F. Hoyt, Jr. ,  Lewis K. Pannell

IPC分类号： A01K1/03

CPC分类号： A01K1/031

摘要： A cage for arboreal animals includes two compartments, each having a hinged, latched, door. The two compartments are separated by a sliding panel to enable maintenance to be performed easily and safely, minimizing unwanted contact between hazardous animals, such as venomous snakes, for example, and the investigators or maintenance personnel. The structure is further ventilated to provide air flow from bottom to top, and could maintain a humidity level in accordance with needs of caged animals. The sides of the cage are transparent to permit simple monitoring of the reptiles as well as to meet the social needs of those animals which need visual contact with other animals in adjacent cages. This cage meets or exceeds all current Federal principles and regulations for animal housing units.

摘要翻译： 一个用于树木动物的笼子包括两个隔间，每个隔间都有一个铰接的，锁定的门。 两个隔间由滑动面板隔开，以使维护工作能够轻松，安全地进行，从而尽可能减少有害动物（例如毒蛇）与调查员或维护人员之间的不必要的接触。 该结构进一步通风，以从底部到顶部提供气流，并且可以根据笼养动物的需要保持湿度水平。 笼子的两侧是透明的，允许简单地监测爬行动物，并满足需要与相邻笼子中的其他动物视觉接触的那些动物的社会需求。 这个笼子达到或超过了目前联邦的动物住房单位的原则和规定。

公开(公告)号：US5083558A

公开(公告)日：1992-01-28

申请号：US609880

申请日：1990-11-06

申请人： William R. Thomas ,  Robert F. Hoyt, Jr.

发明人： William R. Thomas ,  Robert F. Hoyt, Jr.

IPC分类号： A61G10/02 ,  A61G11/00 ,  A61G13/00 ,  B08B15/02 ,  F24F3/16

CPC分类号： A61G13/108 ,  A61G10/02 ,  A61G11/00 ,  B08B15/023 ,  F24F3/1607 ,  Y10S55/18

摘要： Surgical procedures are conducted in a protected environment wherein a laminar flow of micro filtered air is passed from a top to a bottom of an enclosure with transparent panels defining a space for manual access of the surgeon's hands and arms. Air circulation is forced through a high performance HEPA filter between an inlet including the bottom of the enclosure and an outlet at the top, both including panels with an array of apertures for establishing substantially laminar flow. A duct along an endwall of the enclosure carries filtered air to the top. A positive pressure differential is maintained between the inside of the surgical compartment and the outside, to protect the patient operative site from contamination by airborne particles. The enclosure rests on top of a mobile cabinet and has access ports for connection lines and also for bringing the surgical subject into the enclosure. For experimental animals, an access port for cage boxes can be provided. A microscope is movably mounted in the enclosure, with the object lenses disposed outside the enclosure on an extension which can extend through the access port.

摘要翻译： 手术过程在受保护的环境中进行，其中微过滤空气的层流从外壳的顶部到底部通过限定外科医生的手和手臂手动接近的空间的透明面板。 空气循环被迫通过包括外壳底部的入口和顶部的出口之间的高性能HEPA过滤器，两者都包括具有用于建立基本层流的孔阵列的面板。 沿着外壳端壁的导管将过滤的空气运送到顶部。 在手术室的内部和外部之间保持正压差，以保护患者手术部位免受空气传播的颗粒的污染。 外壳位于移动机柜的顶部，并具有用于连接线路的接口，也用于将外科物体带入外壳。 对于实验动物，可以提供笼箱的进入口。 显微镜可移动地安装在外壳中，物镜设置在外壳外部的延伸部上，该延伸部可延伸穿过入口。