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公开(公告)号：US20150045508A1
公开(公告)日：2015-02-12
申请号：US14490891
申请日：2014-09-19
CPC分类号： A61L27/34 , A61L27/54 , A61L33/0029 , A61L33/0035 , A61L33/0076 , A61L33/068 , A61L33/08 , A61L2300/236 , A61L2300/42 , A61L2300/608 , A61L2400/04
摘要： There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.
摘要翻译： 特别地描述了具有包括涂层的表面的医疗装置，所述涂层是生物相容性组合物，其包含能够与哺乳动物血液相互作用以防止凝血或血栓形成的实体，该实体通过一个 连接物包含1,2,3-三唑。
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公开(公告)号：US20100074938A1
公开(公告)日：2010-03-25
申请号：US12559660
申请日：2009-09-15
IPC分类号： A61K9/00 , A61K31/727 , A61P7/02
CPC分类号： A61L27/34 , A61L27/54 , A61L33/0029 , A61L33/0035 , A61L33/0076 , A61L33/068 , A61L33/08 , A61L2300/236 , A61L2300/42 , A61L2300/608 , A61L2400/04
摘要： There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.
摘要翻译： 特别地描述了具有包括涂层的表面的医疗装置，所述涂层是生物相容性组合物，其包含能够与哺乳动物血液相互作用以防止凝血或血栓形成的实体，该实体通过一个 连接物包含1,2,3-三唑。
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3.发明授权公开(公告)号：US08153729B2
公开(公告)日：2012-04-10
申请号：US12156035
申请日：2008-05-29
申请人： Craig J. Hawker , Robert Vestberg , Nobuhiko Ueno
发明人： Craig J. Hawker , Robert Vestberg , Nobuhiko Ueno
IPC分类号： C08F8/00
CPC分类号： C08L101/005 , C08G83/003
摘要： Dendritic macroinitiator compositions are provided comprising a compound of the general formula, Fx-[G-n]-I, where F is the chain end functional group of the dendrimer, x is the number of chain end functional groups, G is the dendrimer, n is the generation number of the dendrimer, and I is the initiating group. Hybrid dendritic-linear copolymers made from these macroinitators can act as highly efficient dispersing agents for a range of nanoparticles in matrix materials.
摘要翻译： 提供树枝状大分子引发剂组合物，其包含通式为Fx- [Gn] -I的化合物，其中F是树枝状聚合物的链端官能团，x是链端官能团的数目，G是树枝状聚合物，n是 树枝状大分子的产生数，I是起始组。 由这些大型化合物制成的混合树枝状 - 线性共聚物可以作为基体材料中一系列纳米粒子的高效分散剂。
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公开(公告)号：US20130273122A1
公开(公告)日：2013-10-17
申请号：US13911727
申请日：2013-06-06
申请人： Robert Vestberg
发明人： Robert Vestberg
IPC分类号： A61K47/48
CPC分类号： A61K47/61 , A61K47/58 , A61K47/59 , A61K47/6957 , A61L33/0029
摘要： There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an anti-coagulant entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which anti-coagulant entity is covalently attached to said surface through a linker comprising a thioether.
摘要翻译： 特别地描述了具有包括涂层的表面的医疗装置，所述涂层是生物相容性组合物，其包含能够与哺乳动物血液相互作用以防止凝血或血栓形成的抗凝血剂实体，所述抗凝剂实体是共价的 通过包含硫醚的接头连接到所述表面。
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公开(公告)号：US08501212B2
公开(公告)日：2013-08-06
申请号：US13045769
申请日：2011-03-11
申请人： Robert Vestberg
发明人： Robert Vestberg
IPC分类号： A61K31/727 , A61K9/00 , A61F2/00 , A61P7/02
CPC分类号： A61K47/61 , A61K47/58 , A61K47/59 , A61K47/6957 , A61L33/0029
摘要： There is described inter alia a medical device having a surface which comprises a coating layer, the coating layer being a biocompatible composition comprising an anti-coagulant entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which anti-coagulant entity is covalently attached to the surface through a linker comprising a thioether.
摘要翻译： 特别地描述了具有包括涂层的表面的医疗装置，所述涂层是生物相容性组合物，其包含能够与哺乳动物血液相互作用以防止凝血或血栓形成的抗凝血剂实体，所述抗凝剂实体是共价的 通过包含硫醚的接头连接到表面。
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公开(公告)号：US20110223229A1
公开(公告)日：2011-09-15
申请号：US13045769
申请日：2011-03-11
申请人： Robert VESTBERG
发明人： Robert VESTBERG
IPC分类号： A61K31/727 , A61K9/00 , A61F2/00 , A61P7/02
CPC分类号： A61K47/61 , A61K47/58 , A61K47/59 , A61K47/6957 , A61L33/0029
摘要： There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an anti-coagulant entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which anti-coagulant entity is covalently attached to said surface through a linker comprising a thioether.
摘要翻译： 特别地描述了具有包括涂层的表面的医疗装置，所述涂层是生物相容性组合物，其包含能够与哺乳动物血液相互作用以防止凝血或血栓形成的抗凝血剂实体，所述抗凝剂实体是共价的 通过包含硫醚的接头连接到所述表面。
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7.发明申请公开(公告)号：US20090299003A1
公开(公告)日：2009-12-03
申请号：US12156035
申请日：2008-05-29
申请人： Craig J. Hawker , Robert Vestberg , Nobuhiko Ueno
发明人： Craig J. Hawker , Robert Vestberg , Nobuhiko Ueno
IPC分类号： C08G63/688
CPC分类号： C08L101/005 , C08G83/003
摘要： Dendritic macroinitiator compositions are provided comprising a compound of the general formula, Fx-[G-n]-I, where F is the chain end functional group of the dendrimer, x is the number of chain end functional groups, G is the dendrimer, n is the generation number of the dendrimer, and I is the initiating group. Hybrid dendritic-linear copolymers made from these macroinitiator can act as highly efficient dispersing agents for a range of nanoparticles in matrix materials.
摘要翻译： 提供树枝状大分子引发剂组合物，其包含通式为Fx- [Gn] -I的化合物，其中F是树枝状聚合物的链端官能团，x是链端官能团的数目，G是树枝状聚合物，n是 树枝状大分子的产生数，I是起始组。 由这些大分子引发剂制备的混合树枝状 - 线性共聚物可以作为基质材料中一系列纳米粒子的高效分散剂。
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公开(公告)号：US08992963B2
公开(公告)日：2015-03-31
申请号：US12559660
申请日：2009-09-15
IPC分类号： A61K9/00 , A61K31/727 , A61P7/02 , A61K31/715 , A61L27/34 , A61L27/54 , A61L33/00
CPC分类号： A61L27/34 , A61L27/54 , A61L33/0029 , A61L33/0035 , A61L33/0076 , A61L33/068 , A61L33/08 , A61L2300/236 , A61L2300/42 , A61L2300/608 , A61L2400/04
摘要： There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.
摘要翻译： 特别地描述了具有包括涂层的表面的医疗装置，所述涂层是生物相容性组合物，其包含能够与哺乳动物血液相互作用以防止凝血或血栓形成的实体，该实体通过一个 连接物包含1,2,3-三唑。
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公开(公告)号：US20160228572A9
公开(公告)日：2016-08-11
申请号：US13911727
申请日：2013-06-06
申请人： Robert Vestberg
发明人： Robert Vestberg
IPC分类号： A61K47/48
CPC分类号： A61K47/61 , A61K47/58 , A61K47/59 , A61K47/6957 , A61L33/0029
摘要： There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an anti-coagulant entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which anti-coagulant entity is covalently attached to said surface through a linker comprising a thioether.
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