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公开(公告)号:US12115224B2
公开(公告)日:2024-10-15
申请号:US17817836
申请日:2022-08-05
发明人: Dehua Pei
CPC分类号: A61K47/64 , A61K47/58 , A61P35/00 , C07K14/001 , C07K14/4703
摘要: The present disclosure provides novel polypeptide conjugates. The polypeptide conjugates disclosed herein comprise a stapled peptide comprising a peptide and at least one staple which holds the peptide in an α-helical conformation, and a cyclic cell-penetrating peptide (cCPP) conjugated, directly or indirectly, to the stapled peptide. The present disclosure demonstrates that cCPPs can be used to confer consistent cell-permeability to stapled peptides.
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公开(公告)号:US20240325307A1
公开(公告)日:2024-10-03
申请号:US18423695
申请日:2024-01-26
CPC分类号: A61K9/1075 , A61K9/146 , A61K47/42 , A61K47/58 , C07K14/001 , C08G61/08 , C08G2261/126 , C08G2261/1424 , C08G2261/1432 , C08G2261/148 , C08G2261/164 , C08G2261/1644 , C08G2261/1646 , C08G2261/3324 , C08G2261/334 , C08G2261/418 , C08G2261/80 , C08G2261/90 , C08G2261/94
摘要: Described herein, inter alia, are peptide containing polymers, and methods of making and using the same.
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公开(公告)号:US12064484B2
公开(公告)日:2024-08-20
申请号:US14901467
申请日:2014-06-27
申请人: ETHRIS GMBH
IPC分类号: A61K47/00 , A61K9/19 , A61K31/7088 , A61K31/713 , A61K47/26 , A61K47/58 , A61K47/59 , A61K48/00 , C08F8/32 , C08G73/02 , C12N15/87
CPC分类号: A61K48/0041 , A61K9/19 , A61K31/713 , A61K47/26 , A61K47/58 , A61K47/59 , C08F8/32 , C08G73/0206 , C08G73/0213 , C12N15/87
摘要: The present invention relates to oligomers, polymers and lipidoids comprising characteristic oligo(alkylene amine) moieties which are useful as vehicles for transfecting a cell with RNA. The present invention furthermore relates to a composition comprising at least a nucleic acid and an oligomer or polymer or a lipidoid comprising such oligo(alkylene amine) moieties and to a method of transfecting a cell using said composition. Furthermore, the present invention relates to pharmaceutical compositions and uses.
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公开(公告)号:US12053529B2
公开(公告)日:2024-08-06
申请号:US17264455
申请日:2019-08-01
发明人: Alan J. Russell , Hironobu Murata
CPC分类号: A61K47/58 , A61K38/1703 , A61K38/47 , A61K38/4826 , A61K47/54 , C12Y302/01017 , C12Y304/21001
摘要: Provided herein are materials and methods that include utilizing atom transfer radical polymerization (ATRP) initiator molecules that maintain a positive charge during biomacro-initiator synthesis.
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公开(公告)号:US20240131170A1
公开(公告)日:2024-04-25
申请号:US18540254
申请日:2023-12-14
发明人: Song Li , Jingjing Sun , Yichao Chen , Yixian Huang , Yanhua Liu , Binfeng Lu
IPC分类号: A61K47/58 , A61K9/107 , A61K31/65 , A61K47/54 , C12N15/113
CPC分类号: A61K47/58 , A61K9/1075 , A61K31/65 , A61K47/549 , C12N15/113 , C12N2310/14 , C12N2310/351
摘要: A formulation includes a plurality of polymers including a hydrophobic polymer backbone (for example, formed via radical polymerization), a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer, a first therapeutic compound, and a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and includes a nucleic acid.
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公开(公告)号:US11857679B2
公开(公告)日:2024-01-02
申请号:US17472819
申请日:2021-09-13
发明人: Edward Turos , Faeez Mahzamani
IPC分类号: A61K9/14 , A61K9/107 , A61P31/04 , A61K47/58 , A61K31/496 , A61K47/20 , A61K47/55 , A61K47/69
CPC分类号: A61K9/1075 , A61K31/496 , A61K47/20 , A61K47/552 , A61K47/58 , A61K47/6907 , A61P31/04
摘要: The subject invention pertains to polyacrylate homopolymers produced from acrylolated drug monomers. The homopolymers can be produced in the form of nanoparticles. The nanoparticles comprising the homopolymers can be produced via a free radical-induced emulsion polymerization of the acrylolated drug monomers to produce an aqueous emulsion of uniformly sized nanoparticles. The homopolymers of the invention containing acrylolated antibiotic monomers can be active against Gram-positive and Gram-negative bacteria, such as Staphylococcus aureus and Escherichia coli. Accordingly, methods are provided of treating a disease, for example, an infection, by administering to a subject the homopolymers, homopolymeric nanoparticles, or emulsions containing homopolymeric nanoparticles of the invention.
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公开(公告)号:US11850325B2
公开(公告)日:2023-12-26
申请号:US17080336
申请日:2020-10-26
发明人: Devyesh Rana , Sidi A. Bencherif , Nasim Annabi
CPC分类号: A61L27/26 , A61K35/15 , A61K47/32 , A61K47/36 , A61K47/58 , A61L27/52 , A61L2300/204 , A61L2400/06
摘要: Disclosed herein are functionalized dopamine derivatives comprising an optionally substituted acrylic acid moiety and optionally a polyethylene glycol linking moiety. The functionalized dopamine derivatives are useful in cryogel formulations to improve the adhesivity of the cryogel, while preventing undesirable oxidation typically associated with dopamine-containing hydrogels and cryogels. Properties such as cryogel adhesivity, pore size, and interconnectivity are tunable features. Also provided herein are methods of treating a wound or promoting tissue regeneration with a cryogel of the invention or a formulation comprising such a cryogel.
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公开(公告)号:US11819531B2
公开(公告)日:2023-11-21
申请号:US15099234
申请日:2016-04-14
申请人: Kodiak Sciences Inc.
IPC分类号: A61K49/00 , A61K47/58 , A61K47/54 , A61K38/00 , A61K47/68 , C12N9/96 , A61K38/18 , A61K38/46 , A61K39/395 , C07K16/00 , C08F8/32 , C08F230/02 , C12N9/16 , C08F230/08
CPC分类号: A61K38/00 , A61K38/1816 , A61K38/465 , A61K39/395 , A61K47/544 , A61K47/58 , A61K47/6805 , A61K47/6811 , A61K49/0002 , A61K49/0043 , A61K49/0054 , C07K16/00 , C08F8/32 , C08F230/02 , C12N9/16 , C12N9/96 , C12Y301/03001 , C07K2317/21 , C07K2317/55 , C08F230/085 , C08F2438/01 , C08F230/02 , C08F230/085
摘要: The present invention provides random copolymers containing zwitterions and one or more functional agents, and methods of preparing such random copolymers.
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公开(公告)号:US20230346715A1
公开(公告)日:2023-11-02
申请号:US18217105
申请日:2023-06-30
申请人: NEXZOL PHARMA, INC.
IPC分类号: A61K31/05 , A61K47/18 , A61K47/58 , A61K47/36 , A61K9/50 , A61K9/06 , A61P37/02 , A61K9/127 , A61K9/00
CPC分类号: A61K31/05 , A61K47/183 , A61K47/58 , A61K47/36 , A61K9/5005 , A61K9/06 , A61P37/02 , A61K9/127 , A61K9/0014
摘要: Described herein are transdermal formulations of phytocannabinoids and methods of using the same in the treatment of pain and/or inflammation.
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公开(公告)号:US11801307B2
公开(公告)日:2023-10-31
申请号:US16334301
申请日:2017-10-13
发明人: Jiyuan Yang , Jindrich Kopecek , Libin Zhang , Yixin Fang
IPC分类号: A61K47/68 , A61P35/00 , C07K16/28 , A61K39/395 , A61K38/07 , A61K47/58 , A61K39/00 , A61K31/337 , A61K31/351
CPC分类号: A61K47/6883 , A61K38/07 , A61K39/395 , A61K47/58 , A61P35/00 , C07K16/2803 , C07K16/2887 , A61K31/337 , A61K31/351 , A61K2039/505 , C07K2317/92 , C07K2319/035
摘要: Disclosed herein, are antibody-polymer-drug conjugates. The conjugate comprises a targeting moiety, one or more polymers, and one or more therapeutic agents. Also described herein, are compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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