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公开(公告)号：US20120231043A1
公开(公告)日：2012-09-13
申请号：US13416880
申请日：2012-03-09
申请人： Karin Leontein , Per Antoni , Daniel Nyström , Paul Begovac , Krzysztof Pietrzak
发明人： Karin Leontein , Per Antoni , Daniel Nyström , Paul Begovac , Krzysztof Pietrzak
IPC分类号： A61K31/785 , C09D161/32 , A61L33/06 , A61P7/02 , B32B9/00 , A61K9/00 , C09D177/00
CPC分类号： A61L33/0011 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0035 , A61L33/0064 , A61L33/0076 , A61L33/068 , A61L33/08 , A61L2300/42 , A61L2300/452 , C08G81/00 , Y10T428/31971 , C08L101/005 , C08L79/02 , C08L79/08
摘要： There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.
摘要翻译： 尤其描述了具有包括层状涂层的表面的装置，其中外涂层包含多个阳离子超支化聚合物分子，其特征在于具有（i）分子量为14-1,000Da的芯部分（ii）总分子量 （iii）总分子量与核心部分分子量的比例为至少80:1，和（iv）官能端基，其中一个或多个所述官能端基具有共价连接的抗凝剂实体 到此。
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公开(公告)号：US08992963B2
公开(公告)日：2015-03-31
申请号：US12559660
申请日：2009-09-15
IPC分类号： A61K9/00 , A61K31/727 , A61P7/02 , A61K31/715 , A61L27/34 , A61L27/54 , A61L33/00
CPC分类号： A61L27/34 , A61L27/54 , A61L33/0029 , A61L33/0035 , A61L33/0076 , A61L33/068 , A61L33/08 , A61L2300/236 , A61L2300/42 , A61L2300/608 , A61L2400/04
摘要： There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.
摘要翻译： 特别地描述了具有包括涂层的表面的医疗装置，所述涂层是生物相容性组合物，其包含能够与哺乳动物血液相互作用以防止凝血或血栓形成的实体，该实体通过一个 连接物包含1,2,3-三唑。
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公开(公告)号：US09408950B2
公开(公告)日：2016-08-09
申请号：US14790205
申请日：2015-07-02
申请人： Karin Leontein , Per Antoni , Daniel Nyström , Paul Begovac , Krzysztof Pietrzak
发明人： Karin Leontein , Per Antoni , Daniel Nyström , Paul Begovac , Krzysztof Pietrzak
IPC分类号： A61L27/14 , A61L27/54 , A61L29/16 , A61L29/08 , A61L31/10 , A61L27/34 , A61L33/00 , C08G81/00
CPC分类号： A61L33/0011 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0035 , A61L33/0064 , A61L33/0076 , A61L33/068 , A61L33/08 , A61L2300/42 , A61L2300/452 , C08G81/00 , Y10T428/31971 , C08L101/005 , C08L79/02 , C08L79/08
摘要： There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.
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公开(公告)号：US09101696B2
公开(公告)日：2015-08-11
申请号：US13416880
申请日：2012-03-09
申请人： Karin Leontein , Per Antoni , Daniel Nyström , Paul Begovac , Krzysztof Pietrzak
发明人： Karin Leontein , Per Antoni , Daniel Nyström , Paul Begovac , Krzysztof Pietrzak
CPC分类号： A61L33/0011 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0035 , A61L33/0064 , A61L33/0076 , A61L33/068 , A61L33/08 , A61L2300/42 , A61L2300/452 , C08G81/00 , Y10T428/31971 , C08L101/005 , C08L79/02 , C08L79/08
摘要： There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.
摘要翻译： 尤其描述了具有包括层状涂层的表面的装置，其中外涂层包含多个阳离子超支化聚合物分子，其特征在于具有（i）分子量为14-1,000Da的芯部分（ii）总分子量 （iii）总分子量与核心部分分子量的比例为至少80:1，和（iv）官能端基，其中一个或多个所述官能端基具有共价连接的抗凝剂实体 到此。
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公开(公告)号：US20150367040A1
公开(公告)日：2015-12-24
申请号：US14790205
申请日：2015-07-02
申请人： Karin Leontein , Per Antoni , Daniel Nyström , Paul Begovac , Krzysztof Pietrzak
发明人： Karin Leontein , Per Antoni , Daniel Nyström , Paul Begovac , Krzysztof Pietrzak
CPC分类号： A61L33/0011 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0035 , A61L33/0064 , A61L33/0076 , A61L33/068 , A61L33/08 , A61L2300/42 , A61L2300/452 , C08G81/00 , Y10T428/31971 , C08L101/005 , C08L79/02 , C08L79/08
摘要： There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.
摘要翻译： 尤其描述了具有包括层状涂层的表面的装置，其中外涂层包含多个阳离子超支化聚合物分子，其特征在于具有（i）分子量为14-1,000Da的芯部分（ii）总分子量 （iii）总分子量与核心部分分子量的比例为至少80:1，和（iv）官能端基，其中一个或多个所述官能端基具有共价连接的抗凝剂实体 到此。
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公开(公告)号：US20150045508A1
公开(公告)日：2015-02-12
申请号：US14490891
申请日：2014-09-19
CPC分类号： A61L27/34 , A61L27/54 , A61L33/0029 , A61L33/0035 , A61L33/0076 , A61L33/068 , A61L33/08 , A61L2300/236 , A61L2300/42 , A61L2300/608 , A61L2400/04
摘要： There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.
摘要翻译： 特别地描述了具有包括涂层的表面的医疗装置，所述涂层是生物相容性组合物，其包含能够与哺乳动物血液相互作用以防止凝血或血栓形成的实体，该实体通过一个 连接物包含1,2,3-三唑。
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公开(公告)号：US20100074938A1
公开(公告)日：2010-03-25
申请号：US12559660
申请日：2009-09-15
IPC分类号： A61K9/00 , A61K31/727 , A61P7/02
CPC分类号： A61L27/34 , A61L27/54 , A61L33/0029 , A61L33/0035 , A61L33/0076 , A61L33/068 , A61L33/08 , A61L2300/236 , A61L2300/42 , A61L2300/608 , A61L2400/04
摘要： There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.
摘要翻译： 特别地描述了具有包括涂层的表面的医疗装置，所述涂层是生物相容性组合物，其包含能够与哺乳动物血液相互作用以防止凝血或血栓形成的实体，该实体通过一个 连接物包含1,2,3-三唑。
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