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    DIPHENYL SULFIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT WHICH CONTAINS SAME AS ACTIVE INGREDIENT
    1.
    发明申请
    DIPHENYL SULFIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT WHICH CONTAINS SAME AS ACTIVE INGREDIENT 有权
    含硫酸盐衍生物和药物产品含有活性成分

    公开(公告)号：US20130261089A1

    公开(公告)日：2013-10-03

    申请号：US13883847

    申请日：2011-12-20

    申请人： Kumi Ishikawa ,  Shigeru Koga ,  Yasushi Kohno ,  Kiyoshi Fujii ,  Ken Yoshikawa

    发明人： Kumi Ishikawa ,  Shigeru Koga ,  Yasushi Kohno ,  Kiyoshi Fujii ,  Ken Yoshikawa

    IPC分类号： C07F9/38

    CPC分类号： C07F9/38 ,  C07F9/091 ,  C07F9/3808 ,  C07F9/4006 ,  C07F9/4015

    摘要： [Problem] To provide a diphenyl sulfide derivative which is useful as a pharmaceutical product that has excellent S1P3 antagonist activity.[Solution] The inventors have discovered that a diphenyl sulfide derivative represented by general formula (1) (wherein R1 represents an alkoxy group having 1-6 carbon atoms, R2 represents a propyl group or an allyl group, X represents methylene or an oxygen atom, and Z represents a halogen atom) has excellent S1P3 antagonist activity as a result of extensive researches for the production of a compound that has S1P3 antagonist activity.

    摘要翻译： [问题]提供可用作具有优异的S1P3拮抗剂活性的药物的二苯硫醚衍生物。 发明人已经发现，通式（1）表示的二苯硫醚衍生物（其中，R1表示碳原子数1〜6的烷氧基，R2表示丙基或烯丙基，X表示亚甲基或氧原子 ，Z表示卤素原子）作为具有S1P3拮抗剂活性的化合物的生产的广泛研究的结果，具有优异的S1P3拮抗剂活性。