公开(公告)号：US11566032B2

公开(公告)日：2023-01-31

申请号：US17315258

申请日：2021-05-07

申请人： TONIX PHARMACEUTICALS, INC. ,  TONIX PHARMACEUTICALS HOLDING CORP.

发明人： Philip S. Schein ,  Darryl C. Rideout

IPC分类号： A61K31/095 ,  C07C321/06 ,  C07F9/24 ,  A61P39/00 ,  A61K45/06 ,  C07D241/04 ,  C07D243/08 ,  C07D243/10 ,  C07D401/04 ,  C07D487/04 ,  C07F9/6574

摘要： The present disclosure relates to prodrugs, double prodrugs, derivatives and analogues of 3-(methylamino)-2-((methylamino)methyl)propane-1-thiol. The compounds of this disclosure also relate to The use of these compounds as radio— and chemo—protectors is also described.

公开(公告)号：US20220185785A1

公开(公告)日：2022-06-16

申请号：US17603260

申请日：2020-04-13

申请人： TONIX PHARMACEUTICALS HOLDING CORP

发明人： Darryl RIDEOUT ,  Seth LEDERMAN

IPC分类号： C07D257/04 ,  C07D403/12 ,  C07D403/10 ,  C07D285/135 ,  C07D275/06 ,  C07D213/81 ,  C07D249/06 ,  C07D307/68 ,  C07C237/42 ,  C07C311/51 ,  C07C317/44 ,  C07D333/38 ,  C07D231/56 ,  C07D211/34 ,  C07D213/52 ,  C07C233/80 ,  C07C259/10 ,  C07D213/75 ,  C07D237/20 ,  C07D401/14 ,  C07D487/04

摘要： Disclosed herein are compounds including pharmaceutically acceptable salts, esters, prodrugs, hydrates and tautomers thereof which modulate the interactions of CD-40-CD40L. The compounds are useful for treating, ameliorating or preventing an autoimmune disease, inflammatory disease, or other immune-related disease in a patient in need of treatment.

公开(公告)号：US20230174562A1

公开(公告)日：2023-06-08

申请号：US17923831

申请日：2021-05-07

申请人： TONIX PHARMACEUTICALS, INC. ,  TONIX PHARMACEUTICALS HOLDING CORP.

发明人： Philip S. Schein ,  Darryl C. Rideout

IPC分类号： C07F9/165 ,  A61K45/06 ,  A61P39/00 ,  A61K31/661 ,  C07D243/08 ,  A61K31/551 ,  C07D241/04 ,  A61K31/495 ,  C07D243/10 ,  C07D245/02 ,  A61K31/395 ,  C07D245/04 ,  C07D487/04 ,  A61K31/4985 ,  C07C53/18 ,  C07D241/38 ,  A61K31/498 ,  C07F9/6571 ,  A61K31/675 ,  C07C323/25 ,  A61K31/145

CPC分类号： C07F9/1651 ,  A61K45/06 ,  A61P39/00 ,  A61K31/661 ,  C07D243/08 ,  A61K31/551 ,  C07D241/04 ,  A61K31/495 ,  C07D243/10 ,  C07D245/02 ,  A61K31/5545 ,  C07D245/04 ,  C07D487/04 ,  A61K31/4985 ,  C07C53/18 ,  C07D241/38 ,  A61K31/498 ,  C07F9/657118 ,  A61K31/675 ,  C07C323/25 ,  A61K31/145 ,  C07B2200/13

摘要： The present disclosure relates to prodrugs, double prodrugs, derivatives and analogues of 3-(methylamino)-2-((methy-lamino)methyl)propane-1-thiol. Their use as radio- and chemo-protectors is also described.

公开(公告)号：US11517557B2

公开(公告)日：2022-12-06

申请号：US16630832

申请日：2018-07-13

申请人： Tonix Pharmaceuticals Holding Corp.

发明人： Seth Lederman ,  Darryl Rideout ,  Greg Sullivan

IPC分类号： A61K31/397 ,  C07C211/32 ,  C07D205/04 ,  A61K45/06 ,  A61K31/135

摘要： The present invention relates to cyclobenzaprine analogs and amitriptyline analogs, including deuterated forms useful for treatment or prevention of symptoms associated with post-traumatic stress disorder.

公开(公告)号：US20220130500A1

公开(公告)日：2022-04-28

申请号：US17508182

申请日：2021-10-22

申请人： TONIX PHARMACEUTICALS HOLDING CORP. ,  TONIX PHARMACEUTICALS INC.

发明人： Seth Lederman ,  Philip B. Stark ,  Ben Vaughn

IPC分类号： G16H10/20 ,  G06F17/18

摘要： Systems and methods for an analysis of clinical trial data using randomization tests that honors the randomized design of the clinical trial are provided herein. In particular, a non-parametric analyzer implementing randomization tests and associated methods for analyzing clinical data is provided. The non-parametric analyzer receives clinical trial data comprising a data structure containing data corresponding to subjects in the clinical trial, where the subjects have been organized into treatment groups, including at least one control group. The non-parametric analyzer generates multiple treatment allocations of the data structure by reorganizing, at random, the subjects along with corresponding data to generate further groups. In some embodiments, the non-parametric analyzer determines the statistical significance based on an overall probability and the multiple allocations of the data structure. The overall probability may be generated via a combination analysis for comparing test statistics between groups of the data structure and the multiple allocations.

公开(公告)号：US20210388011A1

公开(公告)日：2021-12-16

申请号：US17315258

申请日：2021-05-07

申请人： TONIX PHARMACEUTICALS, INC. ,  TONIX PHARMACEUTICALS HOLDING CORP.

发明人： Philip S. Schein ,  Darryl C. Rideout

IPC分类号： C07F9/24 ,  C07F9/6574 ,  C07D241/04 ,  C07D243/08 ,  C07D243/10 ,  C07D401/04 ,  C07D487/04 ,  A61K45/06 ,  A61P39/00

摘要： The present disclosure relates to prodrugs, double prodrugs, derivatives and analogues of 3-(methylamino)-2-((methylamino)methyl)propane-1-thiol. Their use as radio- and chemo-protectors is also described.

公开(公告)号：US20240165126A1

公开(公告)日：2024-05-23

申请号：US18282285

申请日：2022-03-15

申请人： TONIX PHARMACEUTICALS HOLDING CORP. ,  TONIX PHARMA LIMITED

发明人： Seth Lederman ,  Siobhan J. Fogarty

IPC分类号： A61K31/554 ,  A61K9/20 ,  A61K31/485

CPC分类号： A61K31/554 ,  A61K9/2054 ,  A61K31/485

摘要： A composition comprising tianeptine, pharmaceutically acceptable salts thereof or polymorphs of one or both and naloxone or a pharmaceutically acceptable salt thereof, methods of manufacturing the composition, and methods for preventing or treating major depressive disorder (MDD) or symptoms associated therewith comprising administering the composition to a subject in need or at risk thereof.

公开(公告)号：US11970554B2

公开(公告)日：2024-04-30

申请号：US16976912

申请日：2019-03-01

申请人： TONIX PHARMACEUTICALS HOLDING CORP. ,  AARHUS UNIVERSITY

发明人： Steen Jakobsen ,  Michael Winterdahl ,  Erik Nguyen Nielsen ,  David C. Yeomans ,  Dean Carson

IPC分类号： C07K7/16 ,  A61K51/08 ,  G01N33/60

CPC分类号： C07K7/16 ,  A61K51/084 ,  G01N33/60

摘要： Disclosed are 13N-oxytocin molecules, methods of manufacture of 13N-oxytocin molecules and methods of use of 13N-oxytocin molecules in the determination of the distribution and kinetics of 13N-oxytocin molecules after craniofacial or other application methods.

公开(公告)号：US20240024256A1

公开(公告)日：2024-01-25

申请号：US18265525

申请日：2021-12-07

申请人： Tonix Pharmaceuticals Holding Corp.

发明人： Seth Lederman ,  Gregory M. Sullivan

IPC分类号： A61K31/135 ,  A61P25/00 ,  A61K9/00

CPC分类号： A61K31/135 ,  A61P25/00 ,  A61K9/006

摘要： Methods for treating fibromyalgia and one or more of its associated symptoms of pain, sleep disturbance and/or fatigue comprising administering to a subject in need thereof, 5.6 mg cyclobenzaprine HCl per day in one or more dosage units by transmucosal administration, the cyclobenzaprine HCl being in a form of a eutectic, and the one or more dosage units further comprising a basifying agent.

公开(公告)号：US20240009146A1

公开(公告)日：2024-01-11

申请号：US18037815

申请日：2021-11-19

申请人： Tonix Pharmaceuticals Holding Corp.

发明人： Seth Lederman ,  Greg M. Sullivan

IPC分类号： A61K31/137

CPC分类号： A61K31/137

摘要： The present disclosure provides a method for treating alcohol use disorder (AUD) and associated symptoms to a subject in need thereof by administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of cyclobenzaprine or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. The pharmaceutically acceptable salt comprises a cyclobenzaprine acid salt.