公开(公告)号：US08609670B2

公开(公告)日：2013-12-17

申请号：US13592664

申请日：2012-08-23

申请人： Pascale A. J. Pouzet ,  Peter Nickolaus ,  Ulrike Werthmann ,  Rogelio Perez Frutos ,  Bing-Shiou Yang ,  Soojin Kim ,  Jason Alan Mulder ,  Nitinchandra D. Patel ,  Chris Hugh Sananayake ,  Thomas Gabriel Tampone ,  Xudong Wei

发明人： Pascale A. J. Pouzet ,  Peter Nickolaus ,  Ulrike Werthmann ,  Rogelio Perez Frutos ,  Bing-Shiou Yang ,  Soojin Kim ,  Jason Alan Mulder ,  Nitinchandra D. Patel ,  Chris Hugh Sananayake ,  Thomas Gabriel Tampone ,  Xudong Wei

IPC分类号： A61K31/519

CPC分类号： C07D495/04 ,  A61K31/519 ,  A61K45/06 ,  C07B2200/13 ,  C07C213/00 ,  C07D401/04 ,  C07C215/42

摘要： The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.

公开(公告)号：US20130079359A1

公开(公告)日：2013-03-28

申请号：US13592664

申请日：2012-08-23

申请人： Pascale A.J. POUZET ,  Peter NICKOLAUS ,  Ulrike WERTHMANN ,  Rogelio Perez FRUTOS ,  Bing-Shiou YANG ,  Soojin KIM ,  Jason Alan MULDER ,  Nitinchandra D. PATEL ,  Chris Hugh SENANAYAKE ,  Thomas Gabriel TAMPONE ,  Xudong WEI

发明人： Pascale A.J. POUZET ,  Peter NICKOLAUS ,  Ulrike WERTHMANN ,  Rogelio Perez FRUTOS ,  Bing-Shiou YANG ,  Soojin KIM ,  Jason Alan MULDER ,  Nitinchandra D. PATEL ,  Chris Hugh SENANAYAKE ,  Thomas Gabriel TAMPONE ,  Xudong WEI

IPC分类号： C07D495/04 ,  C07C213/00 ,  C07D401/04

CPC分类号： C07D495/04 ,  A61K31/519 ,  A61K45/06 ,  C07B2200/13 ,  C07C213/00 ,  C07D401/04 ,  C07C215/42

摘要： The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.

公开(公告)号：US20130059866A1

公开(公告)日：2013-03-07

申请号：US13402996

申请日：2012-02-23

申请人： Horst Dollinger ,  Rogelio Perez Frutos ,  Soojin Kim ,  Jason Alan Mulder ,  Peter Nickolaus ,  Nitinchandra D. Patel ,  Pascale Pouzet ,  Chris Hugh Senanayake ,  Thomas Gabriel Tampone ,  Xudong Wei ,  Ulrike Werthmann ,  Bing-Shiou Yang

发明人： Horst Dollinger ,  Rogelio Perez Frutos ,  Soojin Kim ,  Jason Alan Mulder ,  Peter Nickolaus ,  Nitinchandra D. Patel ,  Pascale Pouzet ,  Chris Hugh Senanayake ,  Thomas Gabriel Tampone ,  Xudong Wei ,  Ulrike Werthmann ,  Bing-Shiou Yang

IPC分类号： A61K31/519 ,  A61P11/00 ,  A61P1/00 ,  A61P19/02 ,  A61P17/00 ,  A61P27/02 ,  A61P25/00 ,  A61P11/06 ,  A61P1/04 ,  A61P25/28 ,  A61P25/18 ,  A61P25/16 ,  A61P25/04 ,  C07C213/02 ,  C07D401/04 ,  C07D495/04

CPC分类号： C07D495/04 ,  A61K31/519 ,  A61K45/06 ,  C07B2200/13 ,  C07C213/00 ,  C07D401/04 ,  C07C215/42

摘要： The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.

公开(公告)号：US20150045376A1

公开(公告)日：2015-02-12

申请号：US13963513

申请日：2013-08-09

申请人： Pascale A.J. POUZET ,  Peter NICKOLAUS ,  Ulrike WERTHMANN ,  Rogelio P. FRUTOS ,  Bing-Shiou YANG ,  Soojin KIM ,  Jason Alan MULDER ,  Nitinchandra D. PATEL ,  Chris Hugh SENANAYAKE ,  Thomas Gabriel TAMPONE ,  Xudong WEI

发明人： Pascale A.J. POUZET ,  Peter NICKOLAUS ,  Ulrike WERTHMANN ,  Rogelio P. FRUTOS ,  Bing-Shiou YANG ,  Soojin KIM ,  Jason Alan MULDER ,  Nitinchandra D. PATEL ,  Chris Hugh SENANAYAKE ,  Thomas Gabriel TAMPONE ,  Xudong WEI

IPC分类号： C07D495/04

CPC分类号： C07D495/04

摘要： Piperidino-dihydrothienopyrimidine sulfoxides of formula I wherein: Ring A is a 6-membered aromatic ring optionally comprising one or two nitrogen atoms and R is Cl and is located in the para-, meta-, or ortho-position of Ring A, S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.

摘要翻译： 式I的哌啶子基 - 二氢噻吩并嘧啶亚砜其中：环A是任选地包含一个或两个氮原子并且R是Cl并且位于环A的对位，间位或邻位的6元芳香环，S * 是表示手性中心的硫原子及其所有药学上可接受的盐，对映异构体和外消旋体，水合物和溶剂合物，以及这些化合物用于治疗呼吸道炎症或过敏性疾病如COPD或哮喘的用途。