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公开(公告)号：US08633320B2
公开(公告)日：2014-01-21
申请号：US13318706
申请日：2010-05-03
IPC分类号： C07D215/20 , C07F5/02
CPC分类号： C07D215/20 , C07D215/36 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07F5/025
摘要： Disclosed are methods for the preparation of bromo-substituted quinolines of the formula (I) where R is aryl, heteroaryl, alkyl, alkenyl or alkynyl, which are useful as intermediates in the preparation of agents for the treatment of hepatitis C viral (HCV) infections: Formula (I).
摘要翻译： 公开了制备式（I）的溴取代喹啉的方法，其中R是芳基，杂芳基，烷基，烯基或炔基，其可用作制备用于治疗丙型肝炎病毒（HCV）的药剂的中间体 感染：式（I）。
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2.发明申请公开(公告)号：US20130079359A1
公开(公告)日：2013-03-28
申请号：US13592664
申请日：2012-08-23
申请人： Pascale A.J. POUZET , Peter NICKOLAUS , Ulrike WERTHMANN , Rogelio Perez FRUTOS , Bing-Shiou YANG , Soojin KIM , Jason Alan MULDER , Nitinchandra D. PATEL , Chris Hugh SENANAYAKE , Thomas Gabriel TAMPONE , Xudong WEI
发明人： Pascale A.J. POUZET , Peter NICKOLAUS , Ulrike WERTHMANN , Rogelio Perez FRUTOS , Bing-Shiou YANG , Soojin KIM , Jason Alan MULDER , Nitinchandra D. PATEL , Chris Hugh SENANAYAKE , Thomas Gabriel TAMPONE , Xudong WEI
IPC分类号： C07D495/04 , C07C213/00 , C07D401/04
CPC分类号： C07D495/04 , A61K31/519 , A61K45/06 , C07B2200/13 , C07C213/00 , C07D401/04 , C07C215/42
摘要： The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
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3.发明申请公开(公告)号：US20130059866A1
公开(公告)日：2013-03-07
申请号：US13402996
申请日：2012-02-23
申请人： Horst Dollinger , Rogelio Perez Frutos , Soojin Kim , Jason Alan Mulder , Peter Nickolaus , Nitinchandra D. Patel , Pascale Pouzet , Chris Hugh Senanayake , Thomas Gabriel Tampone , Xudong Wei , Ulrike Werthmann , Bing-Shiou Yang
发明人： Horst Dollinger , Rogelio Perez Frutos , Soojin Kim , Jason Alan Mulder , Peter Nickolaus , Nitinchandra D. Patel , Pascale Pouzet , Chris Hugh Senanayake , Thomas Gabriel Tampone , Xudong Wei , Ulrike Werthmann , Bing-Shiou Yang
IPC分类号： A61K31/519 , A61P11/00 , A61P1/00 , A61P19/02 , A61P17/00 , A61P27/02 , A61P25/00 , A61P11/06 , A61P1/04 , A61P25/28 , A61P25/18 , A61P25/16 , A61P25/04 , C07C213/02 , C07D401/04 , C07D495/04
CPC分类号： C07D495/04 , A61K31/519 , A61K45/06 , C07B2200/13 , C07C213/00 , C07D401/04 , C07C215/42
摘要： The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
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公开(公告)号：US20120165534A1
公开(公告)日：2012-06-28
申请号：US13318706
申请日：2010-05-03
IPC分类号： C07D215/20 , C07F5/02
CPC分类号： C07D215/20 , C07D215/36 , C07D401/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07F5/025
摘要： Disclosed are methods for the preparation of bromo-substituted quinolines of the formula (I) where R is aryl, heteroaryl, alkyl, alkenyl or alkynyl, which are useful as intermediates in the preparation of agents for the treatment of hepatitis C viral (HCV) infections: Formula (I).
摘要翻译： 公开了制备式（I）的溴取代喹啉的方法，其中R是芳基，杂芳基，烷基，烯基或炔基，其可用作制备用于治疗丙型肝炎病毒（HCV）的药剂的中间体 感染：式（I）。
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5.发明授权Process for making cytokine inhibiting compounds containing 4- and 5-imidazolyl rings and the intermediates thereof 有权制备含有4-和5-咪唑基环的细胞因子抑制化合物的方法及其中间体公开(公告)号：US07858804B2
公开(公告)日：2010-12-28
申请号：US12295636
申请日：2007-04-16
申请人： Rogelio Perez Frutos , Dhileepkumar Krishnamurthy , Nitinchandra D. Patel , Sonia Rodriguez , Chris Hugh Senanayake
发明人： Rogelio Perez Frutos , Dhileepkumar Krishnamurthy , Nitinchandra D. Patel , Sonia Rodriguez , Chris Hugh Senanayake
IPC分类号： C07D403/04
CPC分类号： C07D403/04 , C07D233/64 , C07F7/0812
摘要： Disclosed are processes for making compounds containing 4- and 5-imidazolyl rings, also disclosed are the intermediates useful in the processes disclosed herein.
摘要翻译： 公开的是制备含有4-和5-咪唑基环的化合物的方法，还公开了可用于本文公开的方法的中间体。
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6.发明申请Process for Making Cytokine Inhibiting Compounds Containing 4- and 5-Imidazolyl Rings and the Intermediates Thereof 有权制备含有4-和5-咪唑环的细胞因子抑制化合物及其中间体的方法公开(公告)号：US20090137815A1
公开(公告)日：2009-05-28
申请号：US12295636
申请日：2007-04-16
申请人： Rogelio Perez Frutos , Dhileepkumar Krishnamurthy , Nitinchandra D. Patel , Sonia Rodriguez , Chris Hugh Senanayake
发明人： Rogelio Perez Frutos , Dhileepkumar Krishnamurthy , Nitinchandra D. Patel , Sonia Rodriguez , Chris Hugh Senanayake
IPC分类号： C07F7/02 , C07D403/04 , C07D233/54
CPC分类号： C07D403/04 , C07D233/64 , C07F7/0812
摘要： Disclosed are processes for making compounds containing 4- and 5-imidazolyl rings, also disclosed are the inter-mediates useful in the processes disclosed herein.
摘要翻译： 公开的是制备含有4-和5-咪唑基环的化合物的方法，还公开了可用于本文公开的方法的中间体。
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7.发明申请NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA 审中-公开新型哌啶二氢吲哚尼酮硫代磷酸酯及其用于治疗COPD和ASTHMA的用途公开(公告)号：US20150045376A1
公开(公告)日：2015-02-12
申请号：US13963513
申请日：2013-08-09
申请人： Pascale A.J. POUZET , Peter NICKOLAUS , Ulrike WERTHMANN , Rogelio P. FRUTOS , Bing-Shiou YANG , Soojin KIM , Jason Alan MULDER , Nitinchandra D. PATEL , Chris Hugh SENANAYAKE , Thomas Gabriel TAMPONE , Xudong WEI
发明人： Pascale A.J. POUZET , Peter NICKOLAUS , Ulrike WERTHMANN , Rogelio P. FRUTOS , Bing-Shiou YANG , Soojin KIM , Jason Alan MULDER , Nitinchandra D. PATEL , Chris Hugh SENANAYAKE , Thomas Gabriel TAMPONE , Xudong WEI
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： Piperidino-dihydrothienopyrimidine sulfoxides of formula I wherein: Ring A is a 6-membered aromatic ring optionally comprising one or two nitrogen atoms and R is Cl and is located in the para-, meta-, or ortho-position of Ring A, S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
摘要翻译： 式I的哌啶子基 - 二氢噻吩并嘧啶亚砜其中：环A是任选地包含一个或两个氮原子并且R是Cl并且位于环A的对位，间位或邻位的6元芳香环，S * 是表示手性中心的硫原子及其所有药学上可接受的盐，对映异构体和外消旋体，水合物和溶剂合物，以及这些化合物用于治疗呼吸道炎症或过敏性疾病如COPD或哮喘的用途。
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公开(公告)号：US20120142929A1
公开(公告)日：2012-06-07
申请号：US13256752
申请日：2010-03-18
IPC分类号： C07D411/04
CPC分类号： C07D417/04
摘要： Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are useful as intermediates in the preparation of potent active agents for the treatment of hepatitis C virus (HCV) infection.
摘要翻译： 公开了用于制备式（I）化合物的高度收敛的方法，该化合物可用作制备用于治疗丙型肝炎病毒（HCV）感染的有效活性剂的中间体。
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公开(公告)号：US09029592B2
公开(公告)日：2015-05-12
申请号：US13761434
申请日：2013-02-07
IPC分类号： C07C269/00 , C07C259/14 , C07C251/40 , C07C47/24 , C07C271/12 , C07C29/143 , C07C45/27 , C07C249/08 , C07F5/02
CPC分类号： C07C259/14 , C07B2200/07 , C07C29/143 , C07C45/27 , C07C47/24 , C07C249/08 , C07C251/40 , C07C269/00 , C07C271/12 , C07C2601/02 , C07F5/025 , C07C33/46
摘要： The present invention relates to a process of making a compound of formula (I): Wherein, R1, R2, R4 and X are as defined herein.
摘要翻译： 本发明涉及制备式（I）化合物的方法：其中R1，R2，R4和X如本文所定义。
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10.发明授权公开(公告)号：US08609670B2
公开(公告)日：2013-12-17
申请号：US13592664
申请日：2012-08-23
申请人： Pascale A. J. Pouzet , Peter Nickolaus , Ulrike Werthmann , Rogelio Perez Frutos , Bing-Shiou Yang , Soojin Kim , Jason Alan Mulder , Nitinchandra D. Patel , Chris Hugh Sananayake , Thomas Gabriel Tampone , Xudong Wei
发明人： Pascale A. J. Pouzet , Peter Nickolaus , Ulrike Werthmann , Rogelio Perez Frutos , Bing-Shiou Yang , Soojin Kim , Jason Alan Mulder , Nitinchandra D. Patel , Chris Hugh Sananayake , Thomas Gabriel Tampone , Xudong Wei
IPC分类号： A61K31/519
CPC分类号： C07D495/04 , A61K31/519 , A61K45/06 , C07B2200/13 , C07C213/00 , C07D401/04 , C07C215/42
摘要： The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.
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