公开(公告)号：US20070122444A1

公开(公告)日：2007-05-31

申请号：US11512863

申请日：2006-08-30

申请人： Richard Timmer ,  Christopher Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Sesha Alluri ,  Koteswar Yeleswarapu ,  Manojit Pal ,  Jangalgar Reddy ,  Velagala Rama Murali Krishna Reddy ,  Potlapally Kumar ,  Gaddam Reddy

发明人： Richard Timmer ,  Christopher Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Sesha Alluri ,  Koteswar Yeleswarapu ,  Manojit Pal ,  Jangalgar Reddy ,  Velagala Rama Murali Krishna Reddy ,  Potlapally Kumar ,  Gaddam Reddy

IPC分类号： A61K31/675 ,  A61K31/55 ,  A61K31/541 ,  A61K31/53

CPC分类号： A61K31/53 ,  C07D251/30 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/66 ,  C07D251/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07F9/6521 ,  C07F9/65583

摘要： The present invention relates to methods, compounds, and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses, and is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention also relates to compounds that inhibit smooth muscle proliferation, for example, by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis. This invention also relates to medical devices, such as a stent, comprising a compound or composition of this invention disposed on or within the medical device.

摘要翻译： 本发明涉及包含治疗由炎性反应引起的病理生理状况的化合物的方法，化合物和组合物，并且涉及抑制或阻断糖基化蛋白质产生内皮细胞中信号传导相关炎症反应诱导的化合物。 本发明还涉及抑制平滑肌增殖的化合物，例如通过调节HSPG如Perlecan。 本发明还涉及化合物用于治疗以平滑肌增生为特征的血管闭塞症状，例如再狭窄和动脉粥样硬化。 本发明还涉及包括设置在医疗装置上或内部的本发明的化合物或组合物的医疗装置，例如支架。