公开(公告)号：US20120142593A1

公开(公告)日：2012-06-07

申请号：US13260564

申请日：2010-03-24

Applicant: Xiao-Yan Zhao ,  Peter John Kretschmer ,  Thomas Eugene Thompson ,  Douglas W. Schneider ,  John Edward Murphy

Inventor： Xiao-Yan Zhao ,  Peter John Kretschmer ,  Thomas Eugene Thompson ,  Douglas W. Schneider ,  John Edward Murphy

IPC: A61K38/37 ,  C12N15/62 ,  C12N15/63 ,  C12N5/10 ,  A61P7/04 ,  C12N1/15 ,  C12N1/19 ,  C12N1/13 ,  C12P21/00 ,  C07K19/00 ,  C12N1/21

CPC classification number: C07K14/755 ,  A61K38/00 ,  C07K2319/30

Abstract: A Factor VIII fusion protein or a Factor VIII fusion heterodimer comprising Factor VIII in which an amino acid sequence of a modulator is present in the B-domain, or an amino acid sequence of a modulator replaces some or all of the amino acid sequence of the B-domain is disclosed. Nucleic acids encoding the inventive fusion proteins and fusion heterodimers are also disclosed, as are methods for producing the fusion proteins and fusion heterodimers, pharmaceutical compositions, and methods of treating deficiencies in coagulation with the inventive fusion molecules.

Abstract translation: 包含因子VIII的因子VIII融合蛋白或因子VIII融合异二聚体，其中调节剂的氨基酸序列存在于B结构域中，或调节剂的氨基酸序列取代了部分或全部氨基酸序列 B域被公开。 还公开了编码本发明的融合蛋白和融合异源二聚体的核酸，以及产生融合蛋白和融合异源二聚体的方法，药物组合物以及用本发明的融合分子治疗凝血缺陷的方法。

公开(公告)号：US20060292074A1

公开(公告)日：2006-12-28

申请号：US11473444

申请日：2006-06-23

Applicant: Tara Heitner ,  David Light ,  Bing Liu ,  Noboru Satozawa ,  Xiao-Yan Zhao

Inventor： Tara Heitner ,  David Light ,  Bing Liu ,  Noboru Satozawa ,  Xiao-Yan Zhao

IPC: A61K51/00 ,  G01N33/574 ,  A61K39/395 ,  C07K16/46 ,  C07K16/30

CPC classification number: C07K16/28 ,  A61K47/6849 ,  A61K47/6869 ,  A61K51/1027 ,  A61K51/1072 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/00 ,  G01N33/56966 ,  G01N33/57434 ,  G01N33/57492

Abstract: The present invention relates to antibodies, and antigen-binding antibody fragments, directed against a Tomoregulin (TR) polypeptide. The invention further relates to methods for utilizing the antibodies, and antibody fragments, for diagnostic and therapeutic applications.

Abstract translation: 本发明涉及抗Tomorgulin（TR）多肽的抗体和抗原结合抗体片段。 本发明还涉及用于诊断和治疗应用的用于使用抗体和抗体片段的方法。

公开(公告)号：US20110077202A1

公开(公告)日：2011-03-31

申请号：US12992879

申请日：2009-05-15

Applicant: Richard Feldman ,  Ji-Yun Kim ,  Haiyan Jiang ,  Kirk Mclean ,  Junliang Pan ,  Glenn Pierce ,  James Wu ,  Xiao-Yan Zhao

Inventor： Richard Feldman ,  Ji-Yun Kim ,  Haiyan Jiang ,  Kirk Mclean ,  Junliang Pan ,  Glenn Pierce ,  James Wu ,  Xiao-Yan Zhao

IPC: A61K38/36 ,  C07K14/745 ,  C07K14/755 ,  A61P7/00

CPC classification number: C07K14/755 ,  A61K38/00 ,  A61K38/37 ,  A61K38/4846 ,  A61K47/64 ,  A61K47/6811 ,  A61K47/6849 ,  C07K16/2839 ,  C07K16/2848 ,  C07K2317/622 ,  C07K2319/30 ,  C07K2319/33

Abstract: Targeted coagulation factors comprising a coagulation factor linked with at least one domain that specifically binds to a membrane protein on a blood cell is provided. The disclosed targeted coagulation factors increase the efficiency of coagulation factors and prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.

Abstract translation: 提供了包含与至少一个与血细胞上的膜蛋白特异性结合的结构域连接的凝血因子的靶向凝血因子。 所公开的靶向凝血因子增加凝血因子的效率并延长其作用时间，因此是治疗血液病如血友病A的改善。