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公开(公告)号：US20110077202A1
公开(公告)日：2011-03-31
申请号：US12992879
申请日：2009-05-15
申请人： Richard Feldman , Ji-Yun Kim , Haiyan Jiang , Kirk Mclean , Junliang Pan , Glenn Pierce , James Wu , Xiao-Yan Zhao
发明人： Richard Feldman , Ji-Yun Kim , Haiyan Jiang , Kirk Mclean , Junliang Pan , Glenn Pierce , James Wu , Xiao-Yan Zhao
IPC分类号： A61K38/36 , C07K14/745 , C07K14/755 , A61P7/00
CPC分类号： C07K14/755 , A61K38/00 , A61K38/37 , A61K38/4846 , A61K47/64 , A61K47/6811 , A61K47/6849 , C07K16/2839 , C07K16/2848 , C07K2317/622 , C07K2319/30 , C07K2319/33
摘要： Targeted coagulation factors comprising a coagulation factor linked with at least one domain that specifically binds to a membrane protein on a blood cell is provided. The disclosed targeted coagulation factors increase the efficiency of coagulation factors and prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.
摘要翻译： 提供了包含与至少一个与血细胞上的膜蛋白特异性结合的结构域连接的凝血因子的靶向凝血因子。 所公开的靶向凝血因子增加凝血因子的效率并延长其作用时间，因此是治疗血液病如血友病A的改善。
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公开(公告)号：US20110286988A1
公开(公告)日：2011-11-24
申请号：US12996629
申请日：2009-06-04
申请人： Haiyan Jiang , Glenn Pierce , John E. Murphy , Junliang Pan , Xin Zhang , Tongyao Liu
发明人： Haiyan Jiang , Glenn Pierce , John E. Murphy , Junliang Pan , Xin Zhang , Tongyao Liu
CPC分类号： A61K38/37
摘要： This invention relates to treatment of von Willebrand Disease by administration of Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties in subjects lacking von Willebrand Factor.
摘要翻译： 本发明涉及通过施用在一个或多个生物相容性聚合物如聚乙二醇上共价结合的不是N-末端胺的预定位点的因子VIII突变蛋白来治疗血管性血友病。 突变蛋白偶联物保留FVIII促凝血活性，并且在缺乏血管性血友病因子的受试者中具有改善的药代动力学性质。
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公开(公告)号：US20120269817A1
公开(公告)日：2012-10-25
申请号：US13057728
申请日：2009-08-04
申请人： Zhuozhi Wang , John E. Murphy , Junliang Pan , Haiyan Jiang , Bing Liu
发明人： Zhuozhi Wang , John E. Murphy , Junliang Pan , Haiyan Jiang , Bing Liu
IPC分类号： A61K39/395 , C12P21/08 , C12N15/13 , C07K16/18 , A61P7/04
摘要： Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) and the isolated nucleic acid molecules encoding them are provided. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.
摘要翻译： 提供了结合人组织因子途径抑制剂（TFPI）的分离的单克隆抗体和编码它们的分离的核酸分子。 还提供了包含抗TFPI单克隆抗体的药物组合物和通过施用抗体治疗缺血或凝血缺陷的方法。 还提供了产生抗体的方法。
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4.发明授权Factor VIII-Fc chimeric and hybrid polypeptides, and methods of use thereof 有权因子VIII-Fc嵌合和杂交多肽及其使用方法公开(公告)号：US09050318B2
公开(公告)日：2015-06-09
申请号：US13513424
申请日：2010-12-06
申请人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
发明人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
IPC分类号： A61K39/395 , A61K38/37 , A61K47/48 , C07K14/755 , C07K16/46
CPC分类号： A61K38/37 , A61K47/643 , A61K47/6811 , C07K14/755 , C07K16/46 , C07K2319/30
摘要： The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
摘要翻译： 本发明提供了施用因子VIII的方法; 包含因子VIII的嵌合和杂交多肽的施用方法; 包含因子VIII的嵌合和杂合多肽; 编码这种嵌合和杂交多肽的多核苷酸; 包含这种多核苷酸的细胞; 以及使用这种细胞产生这种嵌合和杂合多肽的方法。
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5.发明申请公开(公告)号：US20140294821A1
公开(公告)日：2014-10-02
申请号：US14131600
申请日：2012-07-06
申请人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron Mckinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
发明人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron Mckinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
CPC分类号： A61K47/6803 , A61K38/37 , A61K47/60 , A61K47/68 , C07K14/755 , C07K2319/00 , C07K2319/31 , G01N33/86
摘要： The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells
摘要翻译： 本发明提供了施用因子VIII（加工的FVIII，单链FVIII或其组合）的方法; 包含因子VIII的嵌合和杂交多肽的施用方法; 包含因子VIII的嵌合和杂合多肽; 编码这种嵌合和杂交多肽的多核苷酸; 包含这种多核苷酸的细胞; 以及使用这种细胞产生这种嵌合和杂合多肽的方法
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公开(公告)号：US10656167B2
公开(公告)日：2020-05-19
申请号：US14234789
申请日：2012-07-25
申请人： Jurg Sommer , Haiyan Jiang , Xin Zhang , Buyue Yang , Glenn Pierce
发明人： Jurg Sommer , Haiyan Jiang , Xin Zhang , Buyue Yang , Glenn Pierce
摘要： The present invention provides methods of dosing Factor VIII or Factor IX chimeric and hybrid polypeptides. The present invention further provides high-sensitivity methods of quantifying an amount of activated FIX protein in a test sample.
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公开(公告)号：US09670475B2
公开(公告)日：2017-06-06
申请号：US13809276
申请日：2011-07-11
申请人： Glenn Pierce , Samantha Truex , Robert T. Peters , Haiyan Jiang
发明人： Glenn Pierce , Samantha Truex , Robert T. Peters , Haiyan Jiang
IPC分类号： A61K39/00 , C12N9/96 , A61K38/48 , A61K39/395
CPC分类号： A61K38/4846 , A61K9/0019 , A61K38/38 , A61K39/395 , A61K39/39533 , A61K39/3955 , A61K47/643 , C07K14/76 , C07K16/18 , C07K2317/21 , C07K2317/90 , C07K2317/94 , C07K2319/30 , C07K2319/31 , C07K2319/33 , C12N9/644 , C12N9/96 , C12Y304/21022
摘要： The present invention provides methods of administering Factor IX; methods of administering chimeric and hybrid polypeptides comprising Factor IX; chimeric and hybrid polypeptides comprising Factor IX; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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公开(公告)号：US20130202595A1
公开(公告)日：2013-08-08
申请号：US13809276
申请日：2011-07-11
申请人： Glenn Pierce , Samantha Truex , Robert T. Peters , Haiyan Jiang
发明人： Glenn Pierce , Samantha Truex , Robert T. Peters , Haiyan Jiang
IPC分类号： A61K38/48 , A61K39/395
CPC分类号： A61K38/4846 , A61K9/0019 , A61K38/38 , A61K39/395 , A61K39/39533 , A61K39/3955 , A61K47/643 , C07K14/76 , C07K16/18 , C07K2317/21 , C07K2317/90 , C07K2317/94 , C07K2319/30 , C07K2319/31 , C07K2319/33 , C12N9/644 , C12N9/96 , C12Y304/21022
摘要： The present invention provides methods of administering Factor IX; methods of administering chimeric and hybrid polypeptides comprising Factor IX; chimeric and hybrid polypeptides comprising Factor IX; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
摘要翻译： 本发明提供了施用因子IX的方法; 施用包含因子IX的嵌合和杂合多肽的方法; 包含因子IX的嵌合和杂合多肽; 编码这种嵌合和杂交多肽的多核苷酸; 包含这种多核苷酸的细胞; 以及使用这种细胞产生这种嵌合和杂合多肽的方法。
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9.发明申请Factor VIII-Fc Chimeric and Hybrid Polypeptides, and Methods of Use Thereof 有权因子VIII-Fc嵌合和杂交多肽及其使用方法公开(公告)号：US20130108629A1
公开(公告)日：2013-05-02
申请号：US13513424
申请日：2010-12-06
申请人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
发明人： Jennifer A. Dumont , Susan Low , Alan J. Bitonti , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
IPC分类号： C07K14/755 , C07K16/46
CPC分类号： A61K38/37 , A61K47/643 , A61K47/6811 , C07K14/755 , C07K16/46 , C07K2319/30
摘要： The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
摘要翻译： 本发明提供了施用因子VIII的方法; 包含因子VIII的嵌合和杂交多肽的施用方法; 包含因子VIII的嵌合和杂合多肽; 编码这种嵌合和杂交多肽的多核苷酸; 包含这种多核苷酸的细胞; 以及使用这种细胞产生这种嵌合和杂合多肽的方法。
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公开(公告)号：US10010622B2
公开(公告)日：2018-07-03
申请号：US14131600
申请日：2012-07-06
申请人： Jennifer A. Dumont , Susan Low , Alan J. Bitoni , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
发明人： Jennifer A. Dumont , Susan Low , Alan J. Bitoni , Glenn Pierce , Alvin Luk , Haiyan Jiang , Byron McKinney , Matt Ottmer , Jurg Sommer , Karen Nugent , Lian Li , Robert Peters
CPC分类号： A61K47/6803 , A61K38/37 , A61K47/60 , A61K47/68 , C07K14/755 , C07K2319/00 , C07K2319/31 , G01N33/86
摘要： The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.
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