公开(公告)号：US09694149B2

公开(公告)日：2017-07-04

申请号：US14352113

申请日：2012-10-18

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Philip A. Jinks ,  Christopher G. Blatchford

IPC: A61M15/00 ,  B65D83/42 ,  B65B31/00 ,  B65D83/30 ,  B65D83/14 ,  C09K3/30

CPC classification number: A61M15/009 ,  A61M2207/00 ,  A61M2207/10 ,  B65B31/003 ,  B65D83/303 ,  B65D83/752 ,  C09K3/30 ,  F04C2270/0421

Abstract: The present invention relates to methods of making medicinal aerosol canisters (10), in particular metered dose canisters (10), comprising aerosol formulation comprising medicament particles suspended in liquid propellant, for example for delivery by pulmonary or nasal inhalation as well as medicinal dispensers (100) including such canisters (10), such as metered dose medicinal dispenser in particular pressurized metered dose inhalers, wherein the liquid propellant in some embodiments contains HFA 134a and/or HFA 227, and the propellant component is subjected to one or more ultrasonic probes.

公开(公告)号：US20140299128A1

公开(公告)日：2014-10-09

申请号：US14352113

申请日：2012-10-18

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Philip A. Jinks ,  Christopher G. Blatchford

IPC: A61M15/00 ,  B65B31/00

CPC classification number: A61M15/009 ,  A61M2207/00 ,  A61M2207/10 ,  B65B31/003 ,  B65D83/303 ,  B65D83/752 ,  C09K3/30 ,  F04C2270/0421

Abstract: The present invention relates to methods of making medicinal aerosol canisters (10), in particular metered dose canisters (10), comprising aerosol formulation comprising medicament particles suspended in liquid propellant, for example for delivery by pulmonary or nasal inhalation as well as medicinal dispensers (100) including such canisters (10), such as metered dose medicinal dispenser in particular pressurized metered dose inhalers, wherein the liquid propellant in some embodiments contains HFA 134a and/or HFA 227, and the propellant component is subjected to one or more ultrasonic probes.

Abstract translation: 本发明涉及制备药用气溶胶罐（10）的方法，特别是计量剂量罐（10），其包括气溶胶制剂，其包含悬浮在液体推进剂中的药物颗粒，例如通过肺或鼻吸入以及药物分配器递送（ 包括这种罐（10），例如特别是加压计量剂量吸入器的计量剂量药物分配器，其中在一些实施方案中，液体推进剂含有HFA134a和/或HFA227，并且推进剂组分经受一个或多个超声波探针 。