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    MANUFACTURE OF MEDICINAL AEROSOL CANISTERS
    1.
    发明申请
    MANUFACTURE OF MEDICINAL AEROSOL CANISTERS 有权
    医药航空卫生组织制造

    公开(公告)号：US20140299128A1

    公开(公告)日：2014-10-09

    申请号：US14352113

    申请日：2012-10-18

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： Philip A. Jinks ,  Christopher G. Blatchford

    IPC: A61M15/00 ,  B65B31/00

    CPC classification number: A61M15/009 ,  A61M2207/00 ,  A61M2207/10 ,  B65B31/003 ,  B65D83/303 ,  B65D83/752 ,  C09K3/30 ,  F04C2270/0421

    Abstract: The present invention relates to methods of making medicinal aerosol canisters (10), in particular metered dose canisters (10), comprising aerosol formulation comprising medicament particles suspended in liquid propellant, for example for delivery by pulmonary or nasal inhalation as well as medicinal dispensers (100) including such canisters (10), such as metered dose medicinal dispenser in particular pressurized metered dose inhalers, wherein the liquid propellant in some embodiments contains HFA 134a and/or HFA 227, and the propellant component is subjected to one or more ultrasonic probes.

    Abstract translation: 本发明涉及制备药用气溶胶罐（10）的方法，特别是计量剂量罐（10），其包括气溶胶制剂，其包含悬浮在液体推进剂中的药物颗粒，例如通过肺或鼻吸入以及药物分配器递送（ 包括这种罐（10），例如特别是加压计量剂量吸入器的计量剂量药物分配器，其中在一些实施方案中，液体推进剂含有HFA134a和/或HFA227，并且推进剂组分经受一个或多个超声波探针 。

    POLYSILOXANE-BASED PROTECTIVE COATING COMPOSITION FOR HARD SURFACES
    2.
    发明申请
    POLYSILOXANE-BASED PROTECTIVE COATING COMPOSITION FOR HARD SURFACES 有权

    公开(公告)号：US20210079257A1

    公开(公告)日：2021-03-18

    申请号：US15733678

    申请日：2019-05-31

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： Frans A. Audenaert ,  Christoph T. R. Schuell ,  Bernd Kühneweg ,  Hugo R. Lens ,  Philip A. Jinks ,  Wayne W. Fan ,  Inge Nuyts

    IPC: C09D183/04 ,  C09D7/63 ,  C09D7/20 ,  C08G77/388 ,  C08G77/392 ,  C08K5/544

    Abstract: The present disclosure relates to a protective coating composition for a hard surface, wherein the composition comprises an organic solvent and a polysiloxane having the general formula (I), wherein: R1, R2, R3, R4, R5, R6, R7 and R8 are independently an alkyl group having from 1 to 8 carbon atoms; Y and Z are independently a divalent linking group selected from the group consisting of urea, urethane, oxygen atom, sulfur atom and alkylene having from 1 to 8 carbon atoms; A, B, L and M are independently a divalent slinking group selected from the group consisting of alkylene having from 1 to 8 carbon atoms, with the proviso that if the combined linking groups formed by -A-Y-L- and -M-Z—B— are independently an alkylene, then the alkylene is independently different from ethylene; n is an integer from 5 to 1500; and m and p are independently an integer from 1 to 3. In another aspect, the present disclosure is directed to a method of reducing contamination from a hard surface.

    Metered dose inhalers
    4.
    发明授权
    Metered dose inhalers 有权

    公开(公告)号：US10029845B2

    公开(公告)日：2018-07-24

    申请号：US15552401

    申请日：2016-02-22

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： Philip A. Jinks

    IPC: B65D83/14 ,  B65D83/54 ,  A61M15/00 ,  G01F11/14 ,  F16K31/126 ,  F16K7/12

    Abstract: The present invention addresses the problem of turbophoresis and provides a relatively simple and low cost solution for a metered dose inhaler, in particular, a pressure-actuated metered dose inhaler. A metering valve (100) comprises a valve body (110), a valve stem (130) mounted within the valve body (110) and a spring element (140) for biasing the valve stem (130) in an “at rest” position. A pre-metering region (170) is formed in the valve stem (130) which is provided with a miniature valve seal (210) at its inlet (180). The miniature valve seal (210) effectively isolates the pre-metering region (170) from surrounding bulk formulation (4) within a canister (1) in which the metering valve (100) is mounted when the valve stem (130) is in the “at rest” position.

    Medicinal inhalation devices and components thereof
    7.
    发明授权
    Medicinal inhalation devices and components thereof 有权
    药用吸入装置及其部件

    公开(公告)号：US08808786B2

    公开(公告)日：2014-08-19

    申请号：US13855068

    申请日：2013-04-02

    Applicant: 3M Innovative Properties Company

    Inventor： Philip A. Jinks ,  Moses M. David ,  Rudolf J. Dams

    IPC: A61M15/00 ,  B05D3/00 ,  B05D3/14 ,  B32B9/04

    CPC classification number: A61M16/14 ,  A61M11/04 ,  A61M15/0065 ,  A61M15/0086 ,  A61M15/009 ,  A61M15/0091 ,  A61M15/08 ,  B05D1/62 ,  B05D5/083 ,  B05D5/086 ,  B05D2202/15 ,  B65D83/54 ,  C23C16/0245 ,  C23C16/26 ,  C23C16/30 ,  C23C16/401 ,  C23C16/56 ,  Y10T428/265 ,  Y10T428/31663 ,  Y10T428/31667

    Abstract: Medicinal inhalation devices and components having a non-metal coating and a fluorine-containing coating bonded to the non-metal coating wherein the fluorine-containing coating comprises an at least partially fluorinated compound comprising at least one functional group which shares at least one covalent bond with the non-metal coating are provided. In some embodiments, the partially fluorinated compound comprises a polyfluoropolyether silane of Formula Ia: Rf[Q-[C(R)2—Si(Y)3-x(R1a)x]y]z  Ia wherein: Rf is a monovalent or multivalent polyfluoropolyether segment; Q is an organic divalent or trivalent linking group; each R is independently hydrogen or a C1-4 alkyl group; each Y is independently a hydrolysable group; R1a is a C1-8 alkyl or phenyl group; x is 0 or 1 or 2; y is 1 or 2; and z is 1, 2, 3, or 4. Methods of making the devices and components are also provided.

    Abstract translation: 具有与非金属涂层结合的非金属涂层和含氟涂层的医用吸入装置和部件，其中所述含氟涂层包含至少部分氟化的化合物，其包含至少一个共享至少一个共价键的官能团 提供非金属涂层。 在一些实施方案中，部分氟化的化合物包含式Ia的聚氟聚醚硅烷：Rf [Q- [C（R）2-Si（Y）3-x（R1a）x] y] z Ia其中：Rf是单价或 多价多氟聚醚链段 Q是有机二价或三价连接基团; 每个R独立地为氢或C 1-4烷基; 每个Y独立地是可水解基团; R 1a是C 1-8烷基或苯基; x为0或1或2; y为1或2; 并且z是1,2,3或4.还提供了制造器件和部件的方法。

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