公开(公告)号：US20180043055A1

公开(公告)日：2018-02-15

申请号：US15551517

申请日：2016-03-25

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Jason W. Bjork ,  Alexi J Young ,  Raha A. Been ,  Jana Ninkovic ,  Bryan A. Baker

IPC: A61L26/00 ,  A61F13/02 ,  A61L24/10

CPC classification number: A61L26/008 ,  A61F13/0259 ,  A61F2013/00089 ,  A61F2013/00655 ,  A61F2013/00676 ,  A61F2013/00706 ,  A61L24/106 ,  A61L26/0042 ,  A61L26/0071

Abstract: A method of forming a fibrin hydrogel composition is described. The method comprises forming an aqueous solution comprising fibrinogen, fibrin-forming enzyme, and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrin hydrogel. The method further comprises reducing the salt concentration below the threshold concentration to form a fibrin hydrogel. In some embodiments, the aqueous solution further comprises a plasticizer. A fibrin composition is also described comprising a fibrin hydrogel having a fibrin concentration ranging from 0.1 to 10 wt-%; and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt has a concentration less than a threshold concentration to form the fibrin hydrogel. The fibrin hydrogel or dehydrated fibrin hydrogel can be in various physical forms such a sheet, foam, or plurality of pieces. Also described are methods of forming a fibrin article, wound dressings and a method of treatment of a wound.

公开(公告)号：US10973692B2

公开(公告)日：2021-04-13

申请号：US15533733

申请日：2015-12-10

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Joseph D. Rule ,  Döne Demirgöz ,  Jennifer N. Hanson ,  James M. Jonza ,  Gregory J. Anderson ,  Raha A. Been ,  David R. Holm

IPC: A61F13/02 ,  A61F13/00

Abstract: A viscoelastic wound closure dressing. The dressing can include a viscoelastic backing having a first major surface configured to face skin when in use, a first end, a second end, and a middle section located between the first end and the second end. The wound closure dressing can further include a skin-contact adhesive on the first major surface of the viscoelastic backing adjacent the first end and the second end. A majority of the first major surface of the middle section can be free of the skin-contact adhesive. The viscoelastic backing can recover, at room temperature: (i) no more than 40% of its deformation after 10 seconds, after being strained to 50% elongation for 30 minutes, and (ii) at least 70% of its deformation after 48 hours, after being strained to 50% elongation for 30 minutes.

公开(公告)号：US10137222B2

公开(公告)日：2018-11-27

申请号：US15551517

申请日：2016-03-25

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Jason W. Bjork ,  Alexi J Young ,  Raha A. Been ,  Jana Ninkovic ,  Bryan A. Baker

IPC: A61L26/00 ,  A61L24/10 ,  A61F13/02 ,  A61F13/00

Abstract: A method of forming a fibrin hydrogel composition is described. The method comprises forming an aqueous solution comprising fibrinogen, fibrin-forming enzyme, and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrin hydrogel. The method further comprises reducing the salt concentration below the threshold concentration to form a fibrin hydrogel. In some embodiments, the aqueous solution further comprises a plasticizer. A fibrin composition is also described comprising a fibrin hydrogel having a fibrin concentration ranging from 0.1 to 10 wt-%; and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt has a concentration less than a threshold concentration to form the fibrin hydrogel. The fibrin hydrogel or dehydrated fibrin hydrogel can be in various physical forms such a sheet, foam, or plurality of pieces. Also described are methods of forming a fibrin article, wound dressings and a method of treatment of a wound.