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公开(公告)号：US20200337907A1
公开(公告)日：2020-10-29
申请号：US16759090
申请日：2018-10-30
发明人： Robert T. Fitzsimons, Jr. , Bryan A. Baker , Jana Ninkovic , Jie Liu , Federica Sgolastra , Minghua Dai , Wei Zhang , Amy K. McNulty
摘要： An article including: a network of interconnected polymeric strands; wherein each of the interconnected polymeric strands has a first surface adapted to contact a tissue site; wherein none of the interconnected polymeric strand has a feature extending from the first surface of the interconnected polymeric strands; wherein at least one of the interconnected polymeric strands is non-linear; and a plurality of openings between adjacent interconnected polymeric strands; wherein the article is a negative pressure wound therapy article
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公开(公告)号：US10792383B2
公开(公告)日：2020-10-06
申请号：US16096776
申请日：2017-04-25
发明人： Naiyong Jing , Ryan T. Woldt , Wensheng Xia , Kevin D. Landgrebe , Timothy J. Nies , Bryan A. Baker , Semra Colak Atan , Gary W. Jorgensen , Giuseppe M. Bommarito , David P. Swanson , George W. Griesgraber , Ranjani V. Parthasarathy
IPC分类号： A61L2/00 , A61L9/00 , B08B7/00 , B08B9/04 , A61L2/18 , A61L2/28 , A01N35/02 , A01N33/02 , C12Q1/22
摘要： A method of disinfecting a medical device comprises three steps. First, a disinfectant is contacted with a process indicator and the medical device. The disinfectant comprises at least one aldehyde. The process indicator contains a synthetic amine-containing compound disposed on a substrate. The synthetic amine-containing compound comprises at least one of primary amino groups or secondary amino groups, and is reactive with the disinfectant to form at least one adduct. The synthetic amine-containing compound and the medical device are in fluid communication through the disinfectant. A predetermined disinfectant exposure criterion exists for contacting the disinfectant with the medical device. Second, the process indicator is spectrally observed and at least one parameter is obtained therefrom that is predictive of the predetermined disinfectant exposure criterion. The third step is determining that the predetermined disinfectant exposure criterion has been achieved.
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公开(公告)号：US20200368072A1
公开(公告)日：2020-11-26
申请号：US16770989
申请日：2018-12-12
发明人： Amy K. McNulty , Robert T. Fitzsimons , Kurt J. Halverson , Bryan A. Baker , Jana Ninkovic , Jie Liu , Minghua Dai , Wei Zhang , Kiu-Yuen Tse , David R. Holm , Graham M. Clarke , Federica Sgolastra
摘要： An article, including a network of interconnected polymeric strands; wherein each of the interconnected polymeric strands has a first surface adapted to contact a tissue site and a second surface opposite the first surface; wherein at least one of the interconnected polymeric stand has a plurality of features extending from the first surface of the interconnected polymeric strands; wherein at least one of the interconnected polymeric strands is non-linear; a plurality of openings between adjacent interconnected polymeric strands; an adhesive layer in contact with the second surface of the interconnected polymeric strands; and a filler in contact with the adhesive layer, the adhesive layer in between the network of interconnected polymeric strands and the filler; wherein the article is a negative pressure wound therapy article.
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公开(公告)号：US20190183685A1
公开(公告)日：2019-06-20
申请号：US16311508
申请日：2017-06-23
发明人： Amy K. McNulty , Robert T. Fitzsimons, Jr. , Kurt J. Halverson , Bryan A. Baker , Jana Ninkovic , Jie Liu , Minghua Dai , Wei Zhang , Federica Sgolastra
CPC分类号： A61F13/00068 , A61M1/0088 , A61M27/00
摘要： An article, including a network of interconnected polymeric strands; wherein each of the interconnected polymeric strands has a first surface adapted to contact a tissue site; wherein at least one of the interconnected polymeric strand has a plurality of features extending from the first surface of the interconnected polymeric strands; wherein at least one of the interconnected polymeric strands is non-linear; and a plurality of openings between adjacent polymeric strands; wherein the article is a negative pressure wound therapy article.
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公开(公告)号：US20230285629A1
公开(公告)日：2023-09-14
申请号：US18018260
申请日：2021-08-03
IPC分类号： A61L26/00
CPC分类号： A61L26/0033
摘要： An article. The article includes more than 50 wt % collagen matrix, wherein the collagen matrix has a pH value from 2 to 6; wherein the article is a wound dressing.
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公开(公告)号：US20230256131A1
公开(公告)日：2023-08-17
申请号：US18012614
申请日：2021-06-10
CPC分类号： A61L15/18 , A61L15/325 , A61L15/42
摘要： An article and a method of making the article. The article can include a conformable matrix comprising a mixture of collagen and bioactive glass; wherein the article is a conformable wound dressing. The method includes dissolving collagen in an acid solution; adding bioactive glass to the acid solution; mixing collagen and bioactive glass to increase or decrease the pH of the solution; and forming a mixture of collagen and bioactive glass.
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公开(公告)号：US20180043055A1
公开(公告)日：2018-02-15
申请号：US15551517
申请日：2016-03-25
发明人： Jason W. Bjork , Alexi J Young , Raha A. Been , Jana Ninkovic , Bryan A. Baker
CPC分类号： A61L26/008 , A61F13/0259 , A61F2013/00089 , A61F2013/00655 , A61F2013/00676 , A61F2013/00706 , A61L24/106 , A61L26/0042 , A61L26/0071
摘要： A method of forming a fibrin hydrogel composition is described. The method comprises forming an aqueous solution comprising fibrinogen, fibrin-forming enzyme, and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrin hydrogel. The method further comprises reducing the salt concentration below the threshold concentration to form a fibrin hydrogel. In some embodiments, the aqueous solution further comprises a plasticizer. A fibrin composition is also described comprising a fibrin hydrogel having a fibrin concentration ranging from 0.1 to 10 wt-%; and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt has a concentration less than a threshold concentration to form the fibrin hydrogel. The fibrin hydrogel or dehydrated fibrin hydrogel can be in various physical forms such a sheet, foam, or plurality of pieces. Also described are methods of forming a fibrin article, wound dressings and a method of treatment of a wound.
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公开(公告)号：US20230255831A1
公开(公告)日：2023-08-17
申请号：US18018256
申请日：2021-08-03
IPC分类号： A61F13/00
CPC分类号： A61F13/00034
摘要： An article. The article includes a nonwoven having a pH value from 2 to 6; wherein the article is a wound dressing.
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公开(公告)号：US11376164B2
公开(公告)日：2022-07-05
申请号：US16770989
申请日：2018-12-12
发明人： Amy K. McNulty , Robert T. Fitzsimons, Jr. , Kurt J. Halverson , Bryan A. Baker , Jana Ninkovic , Jie Liu , Minghua Dai , Wei Zhang , Kiu-Yuen Tse , David R. Holm , Graham M. Clarke , Federica Sgolastra
摘要： An article, including a network of interconnected polymeric strands; wherein each of the interconnected polymeric strands has a first surface adapted to contact a tissue site and a second surface opposite the first surface; wherein at least one of the interconnected polymeric stand has a plurality of features extending from the first surface of the interconnected polymeric strands; wherein at least one of the interconnected polymeric strands is non-linear; a plurality of openings between adjacent interconnected polymeric strands; an adhesive layer in contact with the second surface of the interconnected polymeric strands; and a filler in contact with the adhesive layer, the adhesive layer in between the network of interconnected polymeric strands and the filler; wherein the article is a negative pressure wound therapy article.
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公开(公告)号：US20200146892A1
公开(公告)日：2020-05-14
申请号：US16624785
申请日：2018-06-12
发明人： Amy K. McNulty , Robert T. Fitzsimons, Jr. , Kurt J. Halverson , Bryan A. Baker , Jana Ninkovic , Jie Liu , Minghua Dai , Wei Zhang , Graham M. Clarke , Federica Sgolastra
摘要： An article, including a network of interconnected polymeric strands; wherein each of the interconnected polymeric strands has a first surface adapted to contact a tissue site; wherein at least one of the interconnected polymeric strand has a plurality of features extending from the first surface of the interconnected polymeric strands; wherein only one of any two adjacent polymeric strands has a plurality of features extending from the first surface of the interconnected polymeric strands; and wherein at least one of the interconnected polymeric strands is non-linear; and a plurality of openings between adjacent interconnected polymeric strands.
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