公开(公告)号：US12252541B2

公开(公告)日：2025-03-18

申请号：US17053256

申请日：2019-06-26

Applicant: ABL BIO INC.

Inventor： Kyungjin Park ,  Hyejin Chung ,  Kyeongsu Park ,  Yangsoon Lee ,  Mikyung Chang ,  Jaehyoung Jeon ,  Youngkwang Kim ,  Junhyun Jeong ,  Jiseon Yoo ,  Yeunju Kim ,  Donghoon Yeom ,  Eunjung Kim ,  Bora Lee ,  Jinwon Jung

IPC: A61K39/395 ,  A61K47/68 ,  A61P35/00 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00 ,  C07K14/705

Abstract: Provided are an antibody or antigen-binding fragment thereof that specifically binds to a B-cell maturation antigen (BCMA), a method of preparing the same, and use thereof. Accordingly, these can be utilized in effectively preventing or treating cancers.

公开(公告)号：US20230192861A1

公开(公告)日：2023-06-22

申请号：US17778382

申请日：2020-11-23

Applicant: ABL BIO INC. ,  I-MAB

Inventor： Eunsil Sung ,  Eunyoung Park ,  Jaehyoung Jeon ,  Junhyun Jeong ,  Daehae Song ,  Sunju Lee ,  Lei Fang ,  Wenqing Jiang ,  Feifei Cui

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2827 ,  C07K16/2878 ,  A61P35/00 ,  C07K2317/31 ,  C07K2317/24 ,  C07K2317/21 ,  C07K2317/92 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/55 ,  C07K2317/732 ,  A61K2039/505

Abstract: The present disclosure provides an anti-PD-L1/anti-B7-H3 multispecific antibody capable to effectively block the interaction between PD-L1 and its receptor PD-1, and suppress the T-cell inhibitory effect of B7-H3 protein. The multispecific antibody may have high binding affinity to both of a PD-L1 protein and a B7-H3 protein.