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1.发明授权公开(公告)号：US12071483B1
公开(公告)日：2024-08-27
申请号：US16770728
申请日：2018-12-14
Applicant: ABL Bio Inc.
Inventor： Jinhyung Ahn , Sungwon An , Dongin Kim , Eunsil Sung , Jaehyun Eom , Sang Hoon Lee , Weonkyoo You , Juhee Kim , Kyungjin Park , Hyejin Chung , Jinwon Jung , Bora Lee , Byungje Sung , Yeunju Kim , Yong-Gyu Son , Seawon Ahn , Daehae Song , Jiseon Yoo , Youngdon Pak , Donghoon Yeom , Yoseob Lee , Jaeho Jung
IPC: A61K39/395 , A61K47/68 , C07K16/18 , C07K16/28
CPC classification number: C07K16/2863 , A61K47/6845 , C07K16/18 , C07K2317/31 , C07K2317/565 , C07K2317/567
Abstract: The present invention relates to a bi-specific antibody that specifically binds to alpha-synuclein and IGF1R, and use of the bi-specific antibody for treating or diagnosing synucleinopathies associated with alpha-synuclein or alpha-synuclein aggregates. The IGF1R portion of the bi-specific antibody acts as a shuttle to penetrate the blood brain barrier, allowing the alpha-synuclein portion to exert its action in the brain. Further, the half-life of the bi-specific antibody may be extended to maintain efficacy over time.
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公开(公告)号：US12252541B2
公开(公告)日：2025-03-18
申请号：US17053256
申请日：2019-06-26
Applicant: ABL BIO INC.
Inventor： Kyungjin Park , Hyejin Chung , Kyeongsu Park , Yangsoon Lee , Mikyung Chang , Jaehyoung Jeon , Youngkwang Kim , Junhyun Jeong , Jiseon Yoo , Yeunju Kim , Donghoon Yeom , Eunjung Kim , Bora Lee , Jinwon Jung
IPC: A61K39/395 , A61K47/68 , A61P35/00 , C07K16/28 , C07K16/30 , A61K39/00 , C07K14/705
Abstract: Provided are an antibody or antigen-binding fragment thereof that specifically binds to a B-cell maturation antigen (BCMA), a method of preparing the same, and use thereof. Accordingly, these can be utilized in effectively preventing or treating cancers.
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公开(公告)号：US12122830B1
公开(公告)日：2024-10-22
申请号：US17057646
申请日：2019-05-23
Applicant: ABL Bio Inc.
Inventor： Yangsoon Lee , Juhee Kim , Kyungjin Park , Donghoon Yeom , Kyeongsu Park , Hyejin Chung , Yeunju Kim , Eunyoung Park , Ui-Jung Jung , Eunsil Sung , Jinhyung Ahn , Byungje Sung , Daehae Song , Youngdon Pak
IPC: C07K16/28 , A61K39/00 , A61P35/00 , G01N33/574
CPC classification number: C07K16/2803 , A61P35/00 , G01N33/57492 , A61K2039/505 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , G01N2333/705 , G01N2333/912
Abstract: The present invention discloses an anti-ROR1 antibody specifically recognizing human and mouse ROR1. The monoclonal antibody can be usefully used for cancer targeting treatment including detection of various cancer expressing ROR1 through specific binding, and drug delivery to specific cancer, etc. as well as a cancer therapeutic agent, by inhibiting tumors.
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公开(公告)号：US11891445B1
公开(公告)日：2024-02-06
申请号：US17057643
申请日：2019-05-24
Applicant: ABL Bio Inc.
Inventor： Kyeongsu Park , Yangsoon Lee , Hyejin Chung , Uijung Jung , Yong-Gyu Son , Sang-Jun Ha , Myeong Joon Kim , Eunyoung Park , Kyungjin Park , Eunsil Sung , Yeunju Kim , Jinhyung Ahn , Byungje Sung , Daehae Song , Youngdon Pak
IPC: C07K16/28 , G01N33/574 , A61P35/00 , A61K39/00
CPC classification number: C07K16/2827 , A61P35/00 , G01N33/57492 , A61K2039/505 , C07K2317/33 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N2333/70532
Abstract: Provided is an anti-B7-H3 antibody specifically recognizing a B7-H3, which can be usefully as a cancer therapeutic agent, as having an inhibitory activity of an immune checkpoint which induces antibody-dependent cell-mediated cytotoxicity and T cell activation inhibited by B7-H3. In particular, the antibody having the inhibitory activity of an immune checkpoint can be used in combination with other immunoantibody therapeutic agents. In addition, it can be usefully used for cancer targeting treatment including detection of various cancers expressing B7-H3 through specific binding to B7-H3, and drug delivery to specific cancer, etc.
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Patent Agency Ranking
公开(公告)号：US12240913B2
公开(公告)日：2025-03-04
申请号：US16939536
申请日：2020-07-27
Applicant: ABL Bio Inc. , YUHAN CORPORATION
Inventor： Hyejin Chung , Yeryoung Yong , Kyeongsu Park , Eunyoung Park , Ui-Jung Jung , Yangsoon Lee , Eunjung Kim , Yong-Gyu Son , Wonjun Son , Seawon Ahn , Donghoon Yeom , Chanmoo Lee , Junghyeon Hong , Moo Young Song , Eun-Jung Lee , Na Rae Lee , Young Bong Park , Eun-Jung Lee , Taewang Kim
Abstract: Provided are an anti-4-1BB/anti-HER2 bispecific antibody, and a pharmaceutical composition and a method for treating and/or preventing a cancer using the same.
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公开(公告)号：US20210024638A1
公开(公告)日：2021-01-28
申请号：US16939472
申请日：2020-07-27
Applicant: ABL Bio Inc. , YUHAN CORPORATION
Inventor： Yeryoung Yong , Ui-Jung Jung , Hyejin Chung , Kyeongsu Park , Wonjun Son , Yangsoon Lee , Yeunju Kim , Eunsil Sung , Youngkwang Kim , Youngdon Pak , Minji Park , Jaehyun Eom , Hyoju Choi , Moo Young Song , Na Rae Lee , Young Bong Park , Eun-Jung Lee , Eun-Jung Lee
Abstract: Provided are an anti-4-1BB/anti-EGFR bispecific antibody, and a pharmaceutical composition and a method for treating and/or preventing a cancer using the same.
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公开(公告)号：US12195538B2
公开(公告)日：2025-01-14
申请号：US17298741
申请日：2019-02-15
Applicant: ABL BIO INC. , I-MAB BIOPHARMA US LIMITED
Inventor： Eunyoung Park , Yangsoon Lee , Hyejin Chung , Eunsil Sung , Jiseon Yoo , Minji Park , Yong-Gyu Son , Hyoju Choi , Eunjung Kim , Jaeho Jung , Weon-Kyoo You , Sang Hoon Lee , Lei Fang , Wenqing Jiang
Abstract: The present disclosure provides an anti-PD-L1/anti-4-1BB bispecific antibody capable to effectively block the interactions between PD-L1 and its receptor PD-1 and between 4-1BB and its ligand. The bispecific antibody may have high binding affinity to both of a PD-L1 protein and a 4-1BB protein.
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公开(公告)号：US12195537B2
公开(公告)日：2025-01-14
申请号：US17296752
申请日：2019-12-02
Applicant: ABL Bio Inc.
Inventor： Eunyoung Park , Yangsoon Lee , Hyejin Chung , Uijung Jung , Youngdon Pak , Jun Hyun Jeong , Yeunju Kim , Seawon Ahn , Byungje Sung
Abstract: Provided is an anti-4-1BB antibody or an antigen-binding fragment thereof, and uses thereof.
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公开(公告)号：US12168690B2
公开(公告)日：2024-12-17
申请号：US16939472
申请日：2020-07-27
Applicant: ABL Bio Inc. , YUHAN CORPORATION
Inventor： Yeryoung Yong , Ui-Jung Jung , Hyejin Chung , Kyeongsu Park , Wonjun Son , Yangsoon Lee , Yeunju Kim , Eunsil Sung , Youngkwang Kim , Youngdon Pak , Minji Park , Jaehyun Eom , Hyoju Choi , Moo Young Song , Na Rae Lee , Young Bong Park , Eun-Jung Lee , Eun-Jung Lee
IPC: C07K16/28 , A61K39/00 , A61K39/395
Abstract: Provided are an anti-4-1BB/anti-EGFR bispecific antibody, and a pharmaceutical composition and a method for treating and/or preventing a cancer using the same.
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