公开(公告)号：US20230094267A1

公开(公告)日：2023-03-30

申请号：US17908585

申请日：2021-03-02

Applicant: ACADEMIA SINICA

Inventor： Che-Ming Jack HU ,  Shih-Yu CHEN ,  Yi-Fu WANG ,  Wan-Chen HSIEH ,  Yi-Shiuan TZENG ,  Ya-Ting LU ,  Jung-Chen LIN ,  Chung-Yao HSU

IPC: C12N5/0783 ,  C07K14/705 ,  C07K14/54

Abstract: A method of expanding natural killer cells, comprising: providing a population of internally gelated cells, each of which includes a gelated interior and a fluid cell membrane that contains one or more membrane-bound proteins each or collectively are capable of stimulating expansion of natural killer (NK) cells; and culturing a population of cells containing NK cells, which are capable of responding to the one or more membrane-bound proteins, with the population of internally gelated cells under conditions that allow expansion of NK cells.