公开(公告)号：US11620749B2

公开(公告)日：2023-04-04

申请号：US17805299

申请日：2022-06-03

Applicant: ACUCELA INC.

Inventor： Stephan Wyder ,  Matthias Pfister ,  Cyril Stoller ,  Philip M. Buscemi

IPC: G06T7/00 ,  G06T7/11 ,  G06T3/00 ,  G06V10/82 ,  G06N3/08 ,  G16H30/40

Abstract: A neural network is trained to segment interferogram images. A first plurality of interferograms are obtained, where each interferograms corresponds to data acquired by an OCT system using a first scan pattern, annotating each of the plurality of interferograms to indicate a tissue structure of a retina, training a neural network using the plurality of interferograms and the annotations, inputting a second plurality of interferograms corresponding to data acquired by an OCT system using a second scan pattern and obtaining an output of the trained neural network indicating the tissue structure of the retina that was scanned using the second scan pattern. The system and methods may instead receive a plurality of A-scans and output a segmented image corresponding to a plurality of locations along an OCT scan pattern.

公开(公告)号：US11974807B2

公开(公告)日：2024-05-07

申请号：US18040186

申请日：2021-08-10

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Stephan Wyder ,  Philip M. Buscemi ,  Matthias Pfister ,  Cyril Stoller

IPC: A61B3/10 ,  G01B9/02091

CPC classification number: A61B3/102 ,  G01B9/02091

Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. Measurement data may be processed using a decurving process to enhance the resolution of the ILM layer and provide improved determinations of retinal thickness.

公开(公告)号：US11798164B2

公开(公告)日：2023-10-24

申请号：US18177560

申请日：2023-03-02

Applicant: ACUCELA INC.

Inventor： Stephan Wyder ,  Matthias Pfister ,  Cyril Stoller ,  Philip M. Buscemi

IPC: G06T7/00 ,  G06T7/11 ,  G06T3/00 ,  G06V10/82 ,  G06N3/08 ,  G16H30/40

CPC classification number: G06T7/0012 ,  G06N3/08 ,  G06T3/00 ,  G06T7/11 ,  G16H30/40 ,  G06T2207/10101 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30041 ,  G06V10/82 ,  G06V2201/03

Abstract: A neural network is trained to segment interferogram images. A first plurality of interferograms are obtained, where each interferograms corresponds to data acquired by an OCT system using a first scan pattern, annotating each of the plurality of interferograms to indicate a tissue structure of a retina, training a neural network using the plurality of interferograms and the annotations, inputting a second plurality of interferograms corresponding to data acquired by an OCT system using a second scan pattern and obtaining an output of the trained neural network indicating the tissue structure of the retina that was scanned using the second scan pattern. The system and methods may instead receive a plurality of A-scans and output a segmented image corresponding to a plurality of locations along an OCT scan pattern.

公开(公告)号：US11369266B2

公开(公告)日：2022-06-28

申请号：US17248870

申请日：2021-02-11

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Stephan Wyder ,  Philip M. Buscemi ,  Matthias Pfister ,  Alexander Holzer

IPC: A61B3/10 ,  G01B9/02 ,  A61B3/12 ,  G01B9/02004 ,  G01B9/02091

Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. The scan pattern is a continuous pattern that includes a plurality of lobes. The measurement beam may be caused to move on the retina by the motion of a mirror that intercepts and redirects the measurement beam. The mirror position may be altered by the application of a drive signal to one or more actuators that respond to the drive signal by rotating the mirror about an axis or axes.

公开(公告)号：US12232810B2

公开(公告)日：2025-02-25

申请号：US18317549

申请日：2023-05-15

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Stephan Wyder ,  Philip M. Buscemi ,  Matthias Pfister ,  Alexander Holzer

IPC: A61B3/10 ,  A61B3/12 ,  G01B9/02004 ,  G01B9/02091

Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. The scan pattern is a continuous pattern that includes a plurality of lobes. The measurement beam may be caused to move on the retina by the motion of a mirror that intercepts and redirects the measurement beam. The mirror position may be altered by the application of a drive signal to one or more actuators that respond to the drive signal by rotating the mirror about an axis or axes.

公开(公告)号：US11779206B2

公开(公告)日：2023-10-10

申请号：US17936263

申请日：2022-09-28

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Philip M. Buscemi ,  Matthias Pfister ,  Stephan Wyder ,  Amitava Gupta

IPC: G01B9/02 ,  A61B3/10 ,  G01B9/02091

CPC classification number: A61B3/102 ,  G01B9/02091 ,  G01B2290/45

Abstract: An OCT axial length measurement device is configured to measure an area of the retina within a range from about 0.05 mm to about 2.0 mm. The area can be measured with a scanned measurement beam or plurality of substantially fixed measurement beams. The OCT measurement device may comprise a plurality of reference optical path lengths, in which a first optical path length corresponds to a first position of a cornea, and a second optical path length corresponds to a second position of the retina, in which the axial length is determined based on a difference between the first position and the second position. An axial length map can be generated to determine alignment of the eye with the measurement device and improve accuracy and repeatability of the measurements. In some embodiments, the OCT measurement device comprises a swept source vertical cavity surface emitting laser (“VCSEL”).

公开(公告)号：US11684254B2

公开(公告)日：2023-06-27

申请号：US17662582

申请日：2022-05-09

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Stephan Wyder ,  Philip M. Buscemi ,  Matthias Pfister ,  Alexander Holzer

IPC: A61B3/10 ,  G01B9/02004 ,  G01B9/02091 ,  A61B3/12

CPC classification number: A61B3/102 ,  A61B3/1225 ,  G01B9/02004 ,  G01B9/02091

Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. The scan pattern is a continuous pattern that includes a plurality of lobes. The measurement beam may be caused to move on the retina by the motion of a mirror that intercepts and redirects the measurement beam. The mirror position may be altered by the application of a drive signal to one or more actuators that respond to the drive signal by rotating the mirror about an axis or axes.

公开(公告)号：US11497396B2

公开(公告)日：2022-11-15

申请号：US17647585

申请日：2022-01-10

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Philip M. Buscemi ,  Matthias Pfister ,  Stephan Wyder ,  Amitava Gupta

IPC: G01B9/02 ,  A61B3/10 ,  G01B9/02091

Abstract: An OCT axial length measurement device is configured to measure an area of the retina within a range from about 0.05 mm to about 2.0 mm. The area can be measured with a scanned measurement beam or plurality of substantially fixed measurement beams. The OCT measurement device may comprise a plurality of reference optical path lengths, in which a first optical path length corresponds to a first position of a cornea, and a second optical path length corresponds to a second position of the retina, in which the axial length is determined based on a difference between the first position and the second position. An axial length map can be generated to determine alignment of the eye with the measurement device and improve accuracy and repeatability of the measurements. In some embodiments, the OCT measurement device comprises a swept source vertical cavity surface emitting laser (“VCSEL”).

公开(公告)号：US10959613B1

公开(公告)日：2021-03-30

申请号：US16947728

申请日：2020-08-13

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Stephan Wyder ,  Philip M. Buscemi ,  Matthias Pfister ,  Alexander Holzer

IPC: A61B3/10 ,  G01B9/02 ,  A61B3/12

Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. The scan pattern is a continuous pattern that includes a plurality of lobes. The measurement beam may be caused to move on the retina by the motion of a mirror that intercepts and redirects the measurement beam. The mirror position may be altered by the application of a drive signal to one or more actuators that respond to the drive signal by rotating the mirror about an axis or axes.