公开(公告)号：US20190077909A1

公开(公告)日：2019-03-14

申请号：US15699416

申请日：2017-09-08

Applicant: International Business Machines Corporation ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (ASTAR)

Inventor： Dylan J. BODAY ,  Willy CHIN ,  Jeannette M. GARCIA ,  James L. HEDRICK ,  Eunice Leong JIAYU ,  Shrinivas VENKATARAMAN ,  Zhi Xiang VOO ,  Rudy J. WOJTECKI ,  Yi Yan YANG

IPC: C08G64/18 ,  C08G64/40 ,  A61K47/34

CPC classification number: C08G64/183 ,  A61K47/34 ,  C08G63/64 ,  C08G64/18 ,  C08G64/406 ,  C08G81/00

Abstract: The present disclosure relates to polythioaminals with applications as carriers or delivery vehicles for therapeutic agents or other small molecule cargo. Polythioaminal block copolymer coupled to a therapeutic agent is a polymer-therapeutic conjugate that exhibits higher stability and longer life time in aqueous environments. The polythioaminal block copolymer coupled to a therapeutic agent can be synthesized by reacting hexahydrotriazines with a hydrophobic block precursor, a hydrophilic block precursor, a particle stabilizing segment precursor, and a cargo, such as a therapeutic agent, in a one pot synthesis. The ease of synthesizing the resulting polythioaminal block copolymer coupled to the therapeutic agent while offering the extended stability and polymer life time in aqueous environments make the polythioaminal block copolymer particularly attractive for therapeutic carriers.

公开(公告)号：US20180325111A1

公开(公告)日：2018-11-15

申请号：US15773993

申请日：2016-10-31

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Yi Yan YANG ,  QingXing XU ,  Majad KHAN ,  Chuan YANG ,  Shrinivas VENKATARAMAN

IPC: A01N43/32 ,  C02F1/50 ,  C08L79/08

CPC classification number: A01N43/32 ,  A01N33/12 ,  A01N37/44 ,  A61K47/59 ,  C02F1/50 ,  C08G73/02 ,  C08L79/08

Abstract: This invention relates to an antibacterial polymer-modified particle comprising a particle core, wherein a polymer is covalently bound to the particle core via a linker and said polymer comprises a branched, amphiphilic cationic polyalkylene imine backbone having amine or amino functional groups and wherein optionally all or some of the amine or amino groups of the polymer have been further reacted with amphiphilic cyclic carbonates carrying a quaternary ammonium group under formation of a urethane bond. In a preferred embodiment the core is a silica core functionalized with the polyelkyleneimine. The invention also relates to methods of making such particles and their use in water disinfection applications.