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公开(公告)号：US20210145970A1
公开(公告)日：2021-05-20
申请号：US17130415
申请日：2020-12-22
Applicant: International Business Machines Corporation , Agency for Science, Technology, and Research (ASTAR)
Inventor： Dylan J. BODAY , Jeannette M. GARCIA , James L. HEDRICK , Nathaniel PARK , Rudy J. WOJTECKI , Yang CHUAN , Ashlynn LEE , Zhen Chang LIANG , Shaoqiong LIU , Yi Yan YANG
Abstract: A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.
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2.发明公开公开(公告)号：US20240352093A1
公开(公告)日：2024-10-24
申请号：US18684884
申请日：2022-08-19
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Lingzhi Ashlynn LEE , Yi Yan YANG
CPC classification number: C07K14/78 , C07K7/06 , C07K7/08 , C12N5/0693 , C12N2533/54
Abstract: Described herein is a hydrogel comprising a peptide and gelatin. The peptide comprises a sequence having at least 8 amino acids with alternating hydrophobic amino acids (X) and hydrophilic amino acids (Y), wherein each hydrophobic amino acid is independently selected from isoleucine (I), valine (V) and leucine (L), each hydrophilic amino acid is independently selected from arginine (R), lysine (K), glutamic acid (E), and aspartic acid (D), wherein the hydrophilic amino acids are selected such that there is at least one arginine and at least one lysine. A kit and method for preparing the hydrogel is described as well. The hydrogel may be used to culture cells and determine an effect of a compound on a cell cultured in the hydrogel.
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公开(公告)号：US20240327469A1
公开(公告)日：2024-10-03
申请号：US18580539
申请日：2022-07-22
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Yi Yan YANG , Shengcai YANG , Wei Ping Eddy TAN
Abstract: The present disclosure relates to functionalised polypeptides, nanoparticles and their 5 uses thereof. The functionalised polypeptide comprises polylysine functionalised with guanidinium moieties, wherein the polypeptide is about 50% to about 98% functionalised. The number of guanidinium functionalised lysine monomeric units is 5 to 100, and the number of lysine monomeric units is 1 to 50. The functionalised polypeptides and nanoparticles can be used for treating a microbial infection or for 10 treating cancer.
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Patent Agency Ranking
公开(公告)号：US20220111115A1
公开(公告)日：2022-04-14
申请号：US17264608
申请日：2019-07-30
Inventor： Yi Yan YANG , Zhen Chang LIANG , Chuan YANG , Ee Jen Wilson WANG
Abstract: There is provided a bone cement composition comprising: a powder component comprising at least one acrylic polymer a liquid component comprising a monomer; an antibiotic; and an acid-functionalised polymer, wherein reaction of the powder component and the liquid component results in formation of a bone cement. In a preferred embodiment, the acid-functionalised polymer is selected from polyethylene glycol-polycarbonate (PEG-PAC), polycarbonate-poly(L-lactide) (PAC-PLLA), polycarbonate-poly(D-lactide) (PAC-PDLA), PAC-PLLA/PDLA, copolymers thereof or a combination thereof. There is also provided a bone cement formed from the bone cement composition.
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公开(公告)号：US20190134210A1
公开(公告)日：2019-05-09
申请号：US15807602
申请日：2017-11-09
Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Dylan BODAY , Wei CHENG , Jeannette M. GARCIA , James HEDRICK , Nathaniel H. PARK , Rudy J. WOJTECKI , Chuan YANG , Yi Yan YANG
IPC: A61K47/60 , A61P35/00 , A61K31/785 , A61K47/69
Abstract: Embodiments of the invention are directed to a macromolecular chemotherapeutic. A non-limiting example of the macromolecular chemotherapeutic includes a block copolymer. The block copolymer can include a water-soluble block, a cationic block, and a linker, wherein the linker is connected to the water-soluble bock and the charged block.
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公开(公告)号：US20190077909A1
公开(公告)日：2019-03-14
申请号：US15699416
申请日：2017-09-08
Applicant: International Business Machines Corporation , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (ASTAR)
Inventor： Dylan J. BODAY , Willy CHIN , Jeannette M. GARCIA , James L. HEDRICK , Eunice Leong JIAYU , Shrinivas VENKATARAMAN , Zhi Xiang VOO , Rudy J. WOJTECKI , Yi Yan YANG
CPC classification number: C08G64/183 , A61K47/34 , C08G63/64 , C08G64/18 , C08G64/406 , C08G81/00
Abstract: The present disclosure relates to polythioaminals with applications as carriers or delivery vehicles for therapeutic agents or other small molecule cargo. Polythioaminal block copolymer coupled to a therapeutic agent is a polymer-therapeutic conjugate that exhibits higher stability and longer life time in aqueous environments. The polythioaminal block copolymer coupled to a therapeutic agent can be synthesized by reacting hexahydrotriazines with a hydrophobic block precursor, a hydrophilic block precursor, a particle stabilizing segment precursor, and a cargo, such as a therapeutic agent, in a one pot synthesis. The ease of synthesizing the resulting polythioaminal block copolymer coupled to the therapeutic agent while offering the extended stability and polymer life time in aqueous environments make the polythioaminal block copolymer particularly attractive for therapeutic carriers.
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7.发明申请公开(公告)号：US20180325111A1
公开(公告)日：2018-11-15
申请号：US15773993
申请日：2016-10-31
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Yi Yan YANG , QingXing XU , Majad KHAN , Chuan YANG , Shrinivas VENKATARAMAN
CPC classification number: A01N43/32 , A01N33/12 , A01N37/44 , A61K47/59 , C02F1/50 , C08G73/02 , C08L79/08
Abstract: This invention relates to an antibacterial polymer-modified particle comprising a particle core, wherein a polymer is covalently bound to the particle core via a linker and said polymer comprises a branched, amphiphilic cationic polyalkylene imine backbone having amine or amino functional groups and wherein optionally all or some of the amine or amino groups of the polymer have been further reacted with amphiphilic cyclic carbonates carrying a quaternary ammonium group under formation of a urethane bond. In a preferred embodiment the core is a silica core functionalized with the polyelkyleneimine. The invention also relates to methods of making such particles and their use in water disinfection applications.
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公开(公告)号：US20170238547A1
公开(公告)日：2017-08-24
申请号：US15519534
申请日：2015-10-14
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Yi Yan YANG , Zhi Xiang VOO
CPC classification number: A01N47/06 , A01N25/08 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2300/404 , C08G64/183 , C08G64/30 , C08G64/40 , C08G65/48 , C08J7/047 , C08J2383/04 , C08J2469/00 , C08J2471/02 , C08J2485/00 , C08L87/005 , C09D5/14 , C09D169/00
Abstract: The present disclosure provides a copolymer comprising monomer units represented by formulas (I) and/or (II) as disclosed and defined herein which are useful in antibacterial and/or antifouling coatings. The present disclosure further provides methods of synthesizing said copolymers.
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