公开(公告)号：US20210380936A1

公开(公告)日：2021-12-09

申请号：US17288140

申请日：2019-10-23

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Youshan Melissa Lin ,  Steve Kah Weng Oh ,  Shaul Reuveny ,  William Richard Nicholas Birch ,  Jian Li ,  Asha Shekaran ,  Tin Lun Alan Lam

IPC: C12N5/00 ,  C12N5/077 ,  A61L27/36

Abstract: The present invention refers to a method of manufacturing an implantable construct comprising chondrogenically differentiated cells and one or more polycaprolactone (PCL) microcarriers, an implantable construct produced using said method, and uses of the implantable construct. The present invention also refers to a method of manufacturing an implantable construct comprising mesenchymal stromal cells and one or more polycaprolactone (PCL) microcarriers, an implantable construct produced using said method, and uses of the implantable construct. The present invention further refers to a method of treating a disease or disorder associated with cartilage and/or bone defect, the method comprises administering one or more cell-free polycaprolactone (PCL) microcarriers in a patient suffering from the disease or disorder.