公开(公告)号：US20170121752A1

公开(公告)日：2017-05-04

申请号：US15311185

申请日：2015-05-14

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Yin Nah TEO ,  Zhi Yi LEE ,  Farid GHADESSY ,  Sarada Srinivasa RAGHAVAN

IPC: C12Q1/02 ,  C09K11/06 ,  G01N21/64

CPC classification number: C12Q1/02 ,  C07D257/04 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1044 ,  G01N21/6428 ,  G01N21/77 ,  G01N2021/6432 ,  G01N2021/7786

Abstract: There is provided a method for detecting the presence or absence of acrylic acid or its derivatives thereof in a sample, the method comprising the steps of: (a) introducing a probe comprising a diaryltetrazole compound to the sample; (b) exposing said sample to light; and (c) detecting the presence or absence of acrylic acid or its derivatives thereof in the sample based on fluorescence emitted by the sample after step (c).

公开(公告)号：US20160297820A1

公开(公告)日：2016-10-13

申请号：US14917935

申请日：2014-09-09

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Yiqi SEOW ,  Fong Tian WONG ,  Yin Nah TEO

IPC: C07D473/18

CPC classification number: C07D473/18 ,  A61K38/00 ,  A61K47/55 ,  A61K47/60

Abstract: There is provided a compound comprising at least two ligands that are individually coupled to a linker, wherein each ligand is independently selected from the group consisting of a substituted benzylguanine derivative, a substituted benzylcytosine derivative, a haloalkyl moiety, a drug, a peptide, a hormone, an inorganic compound and a protein. The compound may be part of an oligomer. The compound may be employed in a method of dimerizing a pair of proteins, which may alter a biological function in a cell. There is also provided a method of forming the compound.

Abstract translation: 提供了包含至少两个分别与接头偶联的配体的化合物，其中每个配体独立地选自取代的苄基鸟嘌呤衍生物，取代的苄基胞嘧啶衍生物，卤代烷基部分，药物，肽， 激素，无机化合物和蛋白质。 该化合物可以是低聚物的一部分。 该化合物可以用于二聚化一对蛋白质的方法，这可能改变细胞中的生物学功能。 还提供了形成化合物的方法。