公开(公告)号：US20240218015A1

公开(公告)日：2024-07-04

申请号：US18598901

申请日：2024-03-07

Applicant: Ajinomoto Co., Inc.

Inventor： Yutaka MATSUDA ,  Yuichi NAKAHARA ,  Kei YAMADA ,  Keisuke KATO ,  Yuta ENDO ,  Brian Alan MENDELSOHN

IPC: C07K1/04 ,  C07K1/02

CPC classification number: C07K1/045 ,  C07K1/02

Abstract: A method for producing an intermediate antibody regioselectively modified, which comprises:



(1) mixing a solution comprising an antibody material and a solution comprising a reagent for regioselectively modifying an antibody in a micromixer to form a mixture comprising the antibody material and the reagent,
wherein the reagent comprises a compound comprising an affinity substance to an antibody and a reactive group to an antibody; and
(2) passing the mixture through a reaction channel to allow the antibody material and the reagent to react in the reaction channel to form a solution comprising an intermediate antibody regioselectively modified,
wherein the processes (1) and (2) are continuously performed in a flow microreactor,
is capable of rapidly producing a desired antibody derivative regioselectively having a functional substance or functional substances.

公开(公告)号：US20220153795A1

公开(公告)日：2022-05-19

申请号：US17588800

申请日：2022-01-31

Applicant: Ajinomoto Co., Inc.

Inventor： Yuta ENDO ,  Mitsuhiro KISHINO ,  Masaya KANEKO

IPC: C07K14/47 ,  C07K1/34

Abstract: High-purity glycomacropeptide with a low phenylalanine content may be obtained on an industrial scale by a method including: (A) bringing a whey protein mixture containing glycomacropeptide into contact with activated carbon; and (B) separating the glycomacropeptide from the activated carbon.

公开(公告)号：US20240018272A1

公开(公告)日：2024-01-18

申请号：US18460810

申请日：2023-09-05

Applicant: AJINOMOTO CO., INC.

Inventor： Yuichi NAKAHARA ,  Yuta ENDO ,  Ippei INOUE ,  Takahiro OKASORA ,  Junko YAMAZAKI HOSHIDA ,  Sachise KARAKAWA

IPC: C07K17/04 ,  C07K14/435

CPC classification number: C07K17/04 ,  C07K14/435

Abstract: the present invention provides a method for producing a protein having a supramolecular structure in which a bioactive substance is encapsulated, comprising: (I) bringing a subunit of a protein, which forms a supramolecular structure, a bioactive substance, and a solution for forming the protein having the supramolecular structure from the subunit into contact with one another in a flow micro mixer.