公开(公告)号：US20220205988A1

公开(公告)日：2022-06-30

申请号：US17336883

申请日：2021-06-02

Applicant: National Yang Ming Chiao Tung University

Inventor： Dean-Mo LIU ,  Yung-Hsin CHANG ,  Wen-Lien WANG ,  Shu-Han LIU

IPC: G01N33/548 ,  C07K14/705 ,  C07K17/04 ,  C07K17/10 ,  G01N33/569 ,  G01N15/06

Abstract: The present invention provides a virus collection matrix, including: a porous gel or fibrous structure formed by a positively charged polymer material; and a plurality of ACE 2 receptors. The plurality of ACE 2 receptors are negatively charged, and distributed and covered on the surface of the porous gel or fibrous structure. The whole virus collection matrix is positively charged.

公开(公告)号：US10947321B2

公开(公告)日：2021-03-16

申请号：US15322976

申请日：2015-05-19

Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION

Inventor： Kang Liang ,  Raffaele Ricco ,  Cara Maxwell Doherty ,  Paolo Falcaro

IPC: C07K17/04 ,  C07H23/00 ,  C12N11/04 ,  C07F3/06 ,  A61K9/50 ,  A61K47/69

Abstract: A method for producing Metal Organic Framework (MOF) having a framework that encapsulates a bio-molecule, the method comprising combining in a solution the bio-molecule and MOF precursors, wherein the bio-molecule promotes formation of the encapsulating framework. The method stems from a surprising effect that a bio-molecule can promote or trigger the formation of MOF when combined together in a solution with MOF precursors. That is, it has now been found that a bio-molecule can effectively act as a seed around which the framework forms, with the resulting framework encapsulating the bio-molecule.

公开(公告)号：US20170166661A1

公开(公告)日：2017-06-15

申请号：US15322976

申请日：2015-05-19

Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION

Inventor： Kang Liang ,  Raffaele Ricco ,  Cara Maxwell Doherty ,  Paolo Falcaro

IPC: C07K17/04 ,  C07H23/00 ,  C12N11/04 ,  C07F3/06

CPC classification number: C07K17/04 ,  A61K9/501 ,  A61K47/6949 ,  C07F3/06 ,  C07H23/00 ,  C12N11/04

Abstract: The present invention relates to a method for producing Metal Organic Framework (MOF) having a framework that encapsulates a bio-molecule, the method comprising combining in a solution the bio-molecule and MOF precursors, wherein the bio-molecule promotes formation of the encapsulating framework.

公开(公告)号：US09574057B2

公开(公告)日：2017-02-21

申请号：US14388886

申请日：2013-03-28

Applicant: Becton, Dickinson and Company

Inventor： Javier Alarcon

IPC: C08F2/46 ,  C08F2/50 ,  C08G61/04 ,  C08J7/18 ,  A61B5/145 ,  A61B5/1455 ,  G01N33/66 ,  C07K17/04

CPC classification number: C08J7/18 ,  A61B5/14532 ,  A61B5/14556 ,  A61B2562/028 ,  C07K17/04 ,  C08J2323/12 ,  C08J2325/06 ,  C08J2367/02 ,  C08J2367/03 ,  C08J2369/00 ,  G01N33/66

Abstract: Methods for adhering a hydrogel matrix to a molded polymer substrate and its use as a biosensor, e.g., a continuous or episodic glucose monitor, are disclosed. The presently disclosed subject matter provides a method for adhering a hydrogel matrix to a molded polymer substrate, the method comprising: (a) molding a polymer comprising one or more polymer chains with an oxidizer to form a molded polymer substrate; (b) providing a hydrogel matrix comprising a hydrogel, a component comprising one or more acrylate groups or another functional group that can form one or more radicals upon polymerization in the molded polymer substrate, and a photo initiator; (c) combining the molded polymer substrate and the hydrogel matrix; and (d) curing the combined molded polymer substrate and hydrogel matrix for a period of time.

Abstract translation: 公开了将水凝胶基质粘附到模制聚合物基底上的方法及其作为生物传感器（例如连续或间歇性葡萄糖监测器）的用途。 目前公开的主题提供了一种将水凝胶基体粘附到模制的聚合物基底上的方法，该方法包括：（a）用氧化剂将包含一个或多个聚合物链的聚合物模制成模制聚合物基底; （b）提供包含水凝胶的水凝胶基质，包含一种或多种丙烯酸酯基团的组分或在模制的聚合物基材中聚合时可以形成一个或多个基团的另一官能团和光引发剂; （c）将模制的聚合物基底和水凝胶基体结合; 和（d）将组合的模制的聚合物基质和水凝胶基质固化一段时间。

公开(公告)号：US09428551B2

公开(公告)日：2016-08-30

申请号：US14278423

申请日：2014-05-15

Applicant: The University of Manchester

Inventor： Mathew Upton ,  Stephanie Sandiford

IPC: A61K38/44 ,  C07K7/08 ,  C07K14/195 ,  A61K8/64 ,  C07K17/04

CPC classification number: C07K7/08 ,  A61K8/64 ,  A61Q11/00 ,  C07K14/195 ,  C07K17/04

Abstract: The present invention provides novel therapeutic antimicrobial peptides that are bactericides and have an inhibitory effect on biofilms produced by biofilm-forming bacteria and especially biofilm-forming Staphyloccocal bacteria. The invention includes the nucleic acids encoding the polypeptides, methods of treating bacterial infections, medical devices or implants or prosthetics impregnated with, covered or coated in the polypeptides, and means of delivery of the peptide to the oral cavity.

Abstract translation: 本发明提供了新型的治疗性抗微生物肽，其是杀菌剂并且对由生物膜形成细菌特别是生物膜形成葡萄球菌产生的生物膜具有抑制作用。 本发明包括编码多肽的核酸，治疗细菌感染的方法，在多肽中浸渍，包被或包被的多肽中的医疗装置或植入物或假体，以及将肽递送至口腔的手段。

公开(公告)号：US20140314823A1

公开(公告)日：2014-10-23

申请号：US14278423

申请日：2014-05-15

Applicant: The University of Manchester

Inventor： Mathew Upton ,  Stephanie Sandiford

IPC: C07K7/08 ,  A61K8/64 ,  C07K17/04

CPC classification number: C07K7/08 ,  A61K8/64 ,  A61Q11/00 ,  C07K14/195 ,  C07K17/04

Abstract: The present invention provides novel therapeutic antimicrobial peptides that are bactericides and have an inhibitory effect on biofilms produced by biofilm-forming bacteria and especially biofilm-forming staphyloccocal bacteria. The invention includes the nucleic acids encoding the polypeptides, methods of treating bacterial infections, medical devices or implants or prosthetics impregnated with, covered or coated in the polypeptides, and means of delivery of the peptide to the oral cavity.

Abstract translation: 本发明提供了新型的治疗性抗微生物肽，其为杀菌剂并且对生物膜形成细菌特别是生物膜形成葡萄球菌属细菌产生的生物膜具有抑制作用。 本发明包括编码多肽的核酸，治疗细菌感染的方法，在多肽中浸渍，包被或包被的多肽中的医疗装置或植入物或假体，以及将肽递送至口腔的手段。

公开(公告)号：US08697111B2

公开(公告)日：2014-04-15

申请号：US12778256

申请日：2010-05-12

Applicant: Arpan Desai ,  Timothy Sargeant ,  Atu Agawu ,  Joshua Stopek

Inventor： Arpan Desai ,  Timothy Sargeant ,  Atu Agawu ,  Joshua Stopek

IPC: A61F2/00 ,  C12N11/02 ,  C12N11/08 ,  C12N11/06 ,  C12N11/04 ,  G01N33/544 ,  G01N33/545 ,  G01N33/549 ,  C07K17/02 ,  C07K17/08 ,  C07K17/06 ,  C07K17/04

CPC classification number: A61L27/50 ,  A61B17/00491 ,  A61B2017/3419 ,  A61L27/14 ,  A61L27/54 ,  A61L27/56

Abstract: An osteochondral plug includes a first scaffold and a second scaffold. The first scaffold may be a solid scaffold containing one or more pendant reactive functional groups. The second scaffold capable of reacting with the one or more pendant reactive functional groups of the first scaffold.

Abstract translation: 骨软骨塞包括第一支架和第二支架。 第一支架可以是含有一个或多个侧链反应性官能团的固体支架。 能够与第一支架的一个或多个侧链反应性官能团反应的第二支架。

公开(公告)号：US07846903B2

公开(公告)日：2010-12-07

申请号：US11665776

申请日：2005-10-19

Applicant: Masakatsu Hato ,  Yoshiji Fujita ,  Toshitaka Ota ,  Masahisa Tanomura ,  Manzo Shiono

Inventor： Masakatsu Hato ,  Yoshiji Fujita ,  Toshitaka Ota ,  Masahisa Tanomura ,  Manzo Shiono

IPC: C09K19/06 ,  C07C9/22 ,  C07H15/04 ,  C07D307/62 ,  C07K17/04 ,  C07K17/10 ,  A61K31/70 ,  A61K31/341 ,  A61K31/185

CPC classification number: A61Q19/00 ,  A61K8/0295 ,  A61K8/345 ,  A61K8/375 ,  A61K8/66 ,  A61K31/575 ,  A61K38/00 ,  A61K47/69 ,  A61K2800/522 ,  A61Q19/02 ,  C07D307/62 ,  C09K19/02 ,  C09K19/04 ,  C09K19/54 ,  C12N9/0089 ,  C12N9/2462

Abstract: A cubic liquid crystal composition comprising at least one amphiphilic compound having the following general formula (1) and having an IV/OV value of 0.65 to 0.95, and water or an aqueous medium: wherein R represents a hydrophilic group; X and Y each independently represent a hydrogen atom or together form an oxygen atom; n is an integer of 0 to 4; and m is an integer of 0 to 3.

Abstract translation: 一种立方晶体组合物，其包含至少一种具有以下通式（1）的两亲化合物和IV / OV值为0.65至0.95的两亲化合物，以及水或水性介质：其中R表示亲水基团; X和Y各自独立地表示氢原子或一起形成氧原子; n为0〜4的整数。 m为0〜3的整数。

公开(公告)号：US20080227873A1

公开(公告)日：2008-09-18

申请号：US11997811

申请日：2005-08-04

Applicant: Sandra I. Laneuville Ballester ,  Sylvie L. Turgeon ,  Christian Sanchez ,  Paul Paquin

Inventor： Sandra I. Laneuville Ballester ,  Sylvie L. Turgeon ,  Christian Sanchez ,  Paul Paquin

IPC: C07K17/04

CPC classification number: C07K14/00 ,  C07K14/76 ,  C08G2210/00 ,  C08J3/075 ,  C08L1/286 ,  C08L5/00 ,  C08L5/04 ,  C08L5/06 ,  C08L5/08 ,  C08L5/12 ,  C08L89/00 ,  C08L89/005 ,  C08L2666/26

Abstract: The present invention concerns the gelation of an undenatured protein and a polysaccharide dispersions by a gradual pH adjustment of their mixture The final pH of the mixture is close to or lower than the isoelectric point of the protein when anionic polysaccharides are used. In the present invention, the undenatured protein and the polysaccharide in the gel state have net opposite electric charges. The concentration of protein and polysaccharide preferably ranges from 0.02 to 10 wt %. The present invention also concerns a gel obtained by this method.

Abstract translation: 本发明涉及通过其混合物的逐渐调节pH调节未变性蛋白质和多糖分散体的凝胶化。当使用阴离子多糖时，混合物的最终pH接近或低于蛋白质的等电点。 在本发明中，未变性蛋白质和凝胶状态的多糖具有相反的电荷。 蛋白质和多糖的浓度优选为0.02〜10重量％。 本发明还涉及通过该方法获得的凝胶。

公开(公告)号：US6056938A

公开(公告)日：2000-05-02

申请号：US73181

申请日：1998-05-05

Applicant: Evan C. Unger ,  Dekang Shen ,  Guanli Wu

Inventor： Evan C. Unger ,  Dekang Shen ,  Guanli Wu

IPC: C12N15/09 ,  A61K9/107 ,  A61K9/127 ,  A61K38/00 ,  A61K47/14 ,  A61K47/16 ,  A61K48/00 ,  A61P37/04 ,  C07C237/10 ,  C07F9/10 ,  C07K14/135 ,  C07K14/50 ,  C12N15/88 ,  C07H21/04 ,  C07K17/04 ,  G01N33/92

CPC classification number: C07K14/005 ,  A61K9/1272 ,  C07C237/10 ,  C07F9/10 ,  C07K14/501 ,  C12N15/88 ,  A61K38/00 ,  A61K48/00 ,  C07C2101/14 ,  C12N2760/18522 ,  Y10S436/829 ,  Y10S977/797 ,  Y10S977/798 ,  Y10S977/80 ,  Y10S977/801 ,  Y10S977/907

Abstract: Cationic lipid compounds which comprise at least two cationic groups. The cationic lipid compounds are particularly suitable for use as carriers in the intracellular delivery of bioactive agents, including pharmaceuticals and genetic material. Compositions of the present cationic lipid compounds include suspensions, emulsions, micelles and liposomes.

Abstract translation: 包含至少两个阳离子基团的阳离子脂质化合物。 阳离子脂质化合物特别适用于细胞内递送生物活性剂（包括药物和遗传物质）中的载体。 本发明的阳离子脂质化合物的组合物包括悬浮液，乳液，胶束和脂质体。