公开(公告)号：US20180087079A1

公开(公告)日：2018-03-29

申请号：US15828215

申请日：2017-11-30

Applicant: AMGEN INC.

Inventor： Zhimei DU ,  John Douglas MCCARTER ,  Pranhitha REDDY ,  Andrew William SNOWDEN ,  Lawrence R. MCGEE ,  John Gordon ALLEN ,  David Lawrence TREIBER ,  Kathleen KEEGAN ,  Zhihong LI

IPC: C12P21/00 ,  C07D471/04 ,  C07K16/00

CPC classification number: C12P21/00 ,  C07D471/04 ,  C07K16/00

Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition of cell cycle inhibitors to growing cell cultures.

公开(公告)号：US20150353542A1

公开(公告)日：2015-12-10

申请号：US14760978

申请日：2013-12-11

Applicant: AMGEN INC.

Inventor： Zhimei DU ,  John Douglas MCCARTER ,  Pranhitha REDDY ,  Andrew William SNOWDEN ,  Lawrence R. MCGEE ,  John Gordon ALLEN ,  David Lawrence TREIBER ,  Kathleen KEEGAN ,  Zhihong LI

IPC: C07D471/04

CPC classification number: C12P21/00 ,  C07D471/04 ,  C07K16/00

Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition of cell cycle inhibitors to growing cell cultures.

Abstract translation: 提供调节表达目的蛋白质的细胞培养物性质的方法。 在各种实施方案中，所述方法涉及将细胞周期抑制剂加入到生长细胞培养物中。

公开(公告)号：US20140199728A1

公开(公告)日：2014-07-17

申请号：US14103418

申请日：2013-12-11

Applicant: Amgen Inc.

Inventor： Zhimei DU ,  John Douglas McCARTER ,  Pranhitha REDDY ,  Andrew William SNOWDEN ,  Lawrence R. MCGEE ,  John Gordon ALLEN ,  David Lawrence TREIBER ,  Kathleen KEEGAN ,  Zhihong LI

IPC: C12P21/00 ,  C07K16/00

CPC classification number: C12P21/00 ,  C07D471/04 ,  C07K16/00

Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition of cell cycle inhibitors to growing cell cultures.

Abstract translation: 提供调节表达目的蛋白质的细胞培养物性质的方法。 在各种实施方案中，所述方法涉及将细胞周期抑制剂加入到生长细胞培养物中。