公开(公告)号：US20220175782A1

公开(公告)日：2022-06-09

申请号：US17579359

申请日：2022-01-19

Applicant: AMGEN INC.

Inventor： John Gordon ALLEN ,  Brian Alan LANMAN ,  Jian CHEN ,  Anthony B. REED ,  Victor J. CEE ,  Longbin LIU ,  Patricia LOPEZ ,  Ryan Paul WURZ ,  Thomas T. NGUYEN ,  Shon BOOKER ,  Jennifer Rebecca ALLEN ,  Margaret CHU-MOYER ,  Albert AMEGADZIE ,  Ning CHEN ,  Clifford GOODMAN ,  Jonathan D. LOW ,  Vu Van MA ,  Ana Elena MINATTI ,  Nobuko NISHIMURA ,  Alexander J. PICKRELL ,  Hui-Ling WANG ,  Youngsook SHIN ,  Aaron C. SIEGMUND ,  Kevin C. YANG ,  Nuria A. TAMAYO ,  Mary WALTON ,  Qiufen XUE

IPC: A61K31/519 ,  A61K31/551 ,  A61K39/395 ,  A61P35/00

Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：US20150353542A1

公开(公告)日：2015-12-10

申请号：US14760978

申请日：2013-12-11

Applicant: AMGEN INC.

Inventor： Zhimei DU ,  John Douglas MCCARTER ,  Pranhitha REDDY ,  Andrew William SNOWDEN ,  Lawrence R. MCGEE ,  John Gordon ALLEN ,  David Lawrence TREIBER ,  Kathleen KEEGAN ,  Zhihong LI

IPC: C07D471/04

CPC classification number: C12P21/00 ,  C07D471/04 ,  C07K16/00

Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition of cell cycle inhibitors to growing cell cultures.

Abstract translation: 提供调节表达目的蛋白质的细胞培养物性质的方法。 在各种实施方案中，所述方法涉及将细胞周期抑制剂加入到生长细胞培养物中。

公开(公告)号：US20240327461A1

公开(公告)日：2024-10-03

申请号：US18497081

申请日：2024-06-11

Applicant: AMGEN INC.

Inventor： Jerry Ryan HOLDER ,  Gayathri SWAMINATH ,  Michael J. FROHN ,  Brian Alan LANMAN ,  Anthony B. REED ,  Leslie P. MIRANDA ,  John Gordon ALLEN ,  Alexander J. PICKRELL ,  Aaron C. SIEGMUND ,  Lewis D. PENNINGTON ,  Bryant YANG

IPC: C07K7/08 ,  A61K38/00 ,  A61K38/10 ,  A61K47/54 ,  A61K47/60 ,  C07K14/47

CPC classification number: C07K7/08 ,  A61K38/10 ,  A61K47/542 ,  A61K47/60 ,  C07K14/47 ,  A61K38/00 ,  C07K2319/30

Abstract: The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.

公开(公告)号：US20220395504A1

公开(公告)日：2022-12-15

申请号：US17363878

申请日：2021-06-30

Applicant: Amgen Inc.

Inventor： John Gordon ALLEN ,  Jennifer Rebecca ALLEN ,  Ana Elena MINATTI ,  Qiufen XUE ,  Ryan Paul WURZ ,  Christopher M. TEGLEY ,  Alexander J. PICKRELL ,  Thomas T. NGUYEN ,  Vu Van MA ,  Patricia LOPEZ ,  Longbin LIU ,  David John KOPECKY ,  Michael J. FROHN ,  Ning CHEN ,  Jian Jeffrey CHEN ,  Aaron C. SIEGMUND ,  Albert AMEGADZIE ,  Nuria A. TAMAYO ,  Shon BOOKER ,  Clifford GOODMAN ,  Mary WALTON ,  Nobuko NISHIMURA ,  Youngsook SHIN ,  Jonathan D. LOW ,  Victor J. CEE ,  Anthony B. REED ,  Hui-Ling WANG ,  Brian Alan LANMAN

IPC: A61K31/517 ,  A61P35/00 ,  A61K31/4985 ,  A61K39/395 ,  C07D403/04 ,  C07D471/04

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：US20210261619A1

公开(公告)日：2021-08-26

申请号：US17160819

申请日：2021-01-28

Applicant: AMGEN INC.

Inventor： Jerry Ryan HOLDER ,  Gayathri SWAMINATH ,  Michael J. FROHN ,  Brian Alan LANMAN ,  Anthony B. REED ,  Leslie P. MIRANDA ,  John Gordon ALLEN ,  Alexander J. PICKRELL ,  Aaron C. SIEGMUND ,  Lewis D. PENNINGTON ,  Bryant YANG

IPC: C07K7/08 ,  C07K14/47 ,  A61K47/54 ,  A61K47/60 ,  A61K38/10

Abstract: The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.

公开(公告)号：US20180087079A1

公开(公告)日：2018-03-29

申请号：US15828215

申请日：2017-11-30

Applicant: AMGEN INC.

Inventor： Zhimei DU ,  John Douglas MCCARTER ,  Pranhitha REDDY ,  Andrew William SNOWDEN ,  Lawrence R. MCGEE ,  John Gordon ALLEN ,  David Lawrence TREIBER ,  Kathleen KEEGAN ,  Zhihong LI

IPC: C12P21/00 ,  C07D471/04 ,  C07K16/00

CPC classification number: C12P21/00 ,  C07D471/04 ,  C07K16/00

Abstract: Methods of modulating the properties of a cell culture expressing a protein of interest are provided. In various embodiments the methods relate to the addition of cell cycle inhibitors to growing cell cultures.

公开(公告)号：US20240254100A1

公开(公告)日：2024-08-01

申请号：US17632333

申请日：2020-08-03

Applicant: AMGEN INC.

Inventor： Nuria A. TAMAYO ,  Matthew Richard KALLER ,  Thomas T. NGUYEN ,  Nobuko NISHIMURA ,  Qiufen May XUE ,  John Gordon ALLEN

IPC: C07D401/04 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/541 ,  C07D241/20 ,  C07D417/14

CPC classification number: C07D401/04 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/541 ,  C07D241/20 ,  C07D417/14

Abstract: Compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

公开(公告)号：US20210108212A1

公开(公告)日：2021-04-15

申请号：US17080771

申请日：2020-10-26

Applicant: AMGEN INC.

Inventor： Michael OLLMANN ,  Yang LI ,  Jun ZHANG ,  Kaustav BISWAS ,  Oliver HOMANN ,  Leslie P. MIRANDA ,  Justin K. MURRAY ,  Bin WU ,  Oh Kyu YOON ,  John Gordon ALLEN ,  Chawita NETIROJJANAKUL ,  Yuan CHENG

IPC: C12N15/113 ,  A61P9/10 ,  A61P3/06 ,  C07K16/28

Abstract: The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.

公开(公告)号：US20200055845A1

公开(公告)日：2020-02-20

申请号：US16661907

申请日：2019-10-23

Applicant: Amgen Inc.

Inventor： Brian Alan LANMAN ,  Jian CHEN ,  Anthony B. REED ,  Victor J. CEE ,  Longbin LIU ,  David John KOPECKY ,  Patricia LOPEZ ,  Ryan Paul WURZ ,  Thomas T. NGUYEN ,  Shon BOOKER ,  Nobuko NISHIMURA ,  Youngsook SHIN ,  Nuria A. TAMAYO ,  John Gordon ALLEN ,  Jennifer Rebecca ALLEN

IPC: C07D417/04 ,  C07D475/00 ,  C07D275/04 ,  A61K31/7068 ,  A61P35/00 ,  A61K31/5025 ,  A61K31/502 ,  A61K31/519 ,  A61K31/517 ,  A61K31/454 ,  A61K31/55 ,  A61K31/416 ,  A61K31/496 ,  C07D403/04 ,  C07D237/34 ,  C07D401/14 ,  C07D239/80 ,  C07D401/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10 ,  C07D513/04 ,  C07D417/12 ,  C07D487/08 ,  A61K38/07

Abstract: Provided herein are methods of using KRAS G12C inhibitors and compositions of the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

公开(公告)号：US20200030324A1

公开(公告)日：2020-01-30

申请号：US16428163

申请日：2019-05-31

Applicant: Amgen Inc.

Inventor： Shon BOOKER ,  John Gordon ALLEN ,  Brian Alan LANMAN ,  Ryan Paul WURZ ,  Ning CHEN ,  Victor J. CEE ,  Patricia LOPEZ ,  Aaron C. SIEGMUND ,  Michael D. BARTBERGER

IPC: A61K31/497 ,  C07K16/28

Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.