公开(公告)号：US11873343B2

公开(公告)日：2024-01-16

申请号：US17529794

申请日：2021-11-18

Applicant: AMGEN INC.

Inventor： Stephen Robert Brych ,  Lyanne M. Wong ,  Jaymille Fallon ,  Monica Michelle Goss ,  Jian Hua Gu ,  Pavan K. Ghattyvenkatakrishna

IPC: C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2875 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/76

Abstract: Disclosed herein are aqueous pharmaceutical formulations comprising denosumab or another human anti-RANKL monoclonal antibody or portion thereof, and characteristics of pH, buffer systems, and amino acid aggregation inhibitors. Also disclosed are presentation of the formulation for use, e.g. in a single-use vial, single-use syringe, or glass container, methods of using the formulations and articles for preventing or treating diseases, and related kits.

公开(公告)号：US12257343B2

公开(公告)日：2025-03-25

申请号：US16609448

申请日：2018-04-24

Applicant: AMGEN INC.

Inventor： Jian Hua Gu ,  Robert Matthew Fesinmeyer ,  Rulin Qian

IPC: A61K9/08 ,  A61K9/19 ,  A61K47/18 ,  C07K16/24 ,  C07K16/40

Abstract: This invention concerns a series of excipients capable of effectively reducing the viscosity of protein formulations. The viscosity reducing excipients are oligopeptides (e.g., dipeptides, tripeptides) comprising at least one arginine. The peptides may also include basic or acidic or hydrophilic or hydrophobic/aromatic amino acids. An arginine residue may be either at the amino or the carboxyl end of the oligopeptide.

公开(公告)号：US11192952B2

公开(公告)日：2021-12-07

申请号：US16608375

申请日：2018-04-27

Applicant: AMGEN INC.

Inventor： Stephen Robert Brych ,  Lyanne M. Wong ,  Jaymille Fallon ,  Monica Michelle Goss ,  Jian Hua Gu ,  Pavan Ghattyvenkatakrishna

IPC: C07K16/28 ,  A61K39/00

Abstract: Disclosed herein are aqueous pharmaceutical formulations comprising denosumab or another human anti-RANKL monoclonal antibody or portion thereof, and characteristics of pH, buffer systems, and amino acid aggregation inhibitors. Also disclosed are presentation of the formulation for use, e.g. in a single-use vial, single-use syringe, or glass container, methods of using the formulations and articles for preventing or treating diseases, and related kits.