公开(公告)号：US11192952B2

公开(公告)日：2021-12-07

申请号：US16608375

申请日：2018-04-27

申请人： AMGEN INC.

发明人： Stephen Robert Brych ,  Lyanne M. Wong ,  Jaymille Fallon ,  Monica Michelle Goss ,  Jian Hua Gu ,  Pavan Ghattyvenkatakrishna

IPC分类号： C07K16/28 ,  A61K39/00

摘要： Disclosed herein are aqueous pharmaceutical formulations comprising denosumab or another human anti-RANKL monoclonal antibody or portion thereof, and characteristics of pH, buffer systems, and amino acid aggregation inhibitors. Also disclosed are presentation of the formulation for use, e.g. in a single-use vial, single-use syringe, or glass container, methods of using the formulations and articles for preventing or treating diseases, and related kits.

公开(公告)号：US11873343B2

公开(公告)日：2024-01-16

申请号：US17529794

申请日：2021-11-18

申请人： AMGEN INC.

发明人： Stephen Robert Brych ,  Lyanne M. Wong ,  Jaymille Fallon ,  Monica Michelle Goss ,  Jian Hua Gu ,  Pavan K. Ghattyvenkatakrishna

IPC分类号： C07K16/28 ,  A61K39/00

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/76

摘要： Disclosed herein are aqueous pharmaceutical formulations comprising denosumab or another human anti-RANKL monoclonal antibody or portion thereof, and characteristics of pH, buffer systems, and amino acid aggregation inhibitors. Also disclosed are presentation of the formulation for use, e.g. in a single-use vial, single-use syringe, or glass container, methods of using the formulations and articles for preventing or treating diseases, and related kits.

公开(公告)号：US20220087901A1

公开(公告)日：2022-03-24

申请号：US17425412

申请日：2020-02-12

申请人： AMGEN INC.

发明人： Nicholas J. Clark ,  Chia-Jung Wu ,  Mingda Eu ,  Artemio A. Alanis ,  Jennifer Lyn Sawicky ,  Monica Goss ,  Jennifer Stevenson ,  Heather N. Franey ,  Deirdre Piedmonte ,  Stephen Robert Brych

IPC分类号： A61J1/20 ,  A61M39/00

摘要： An approach for preparing a drug delivery device includes providing a prefilled delivery container and transferring a drug product contained in a drug container to the prefilled delivery container. The prefilled delivery container includes a container body containing a predetermined quantity of saline solution and a predetermined quantity of IV stabilizing solution (“IVSS”). The drug product is transferred to the prefilled delivery container via a delivery container adapter.