专利检索 ap:("AMGEN INC.") AND inv:"Pavan K. Ghattyvenkatakrishna" 第 1 页

1.

发明授权
Pharmaceutical formulations comprising anti-RANKL antibodies and an aromatic amino acid comprising a phenyl or an indole 有权

公开(公告)号：US11873343B2

公开(公告)日：2024-01-16

申请号：US17529794

申请日：2021-11-18

申请人： AMGEN INC.

发明人： Stephen Robert Brych , Lyanne M. Wong , Jaymille Fallon , Monica Michelle Goss , Jian Hua Gu , Pavan K. Ghattyvenkatakrishna

IPC分类号： C07K16/28 , A61K39/00

CPC分类号： C07K16/2875 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/55 , C07K2317/76

摘要： Disclosed herein are aqueous pharmaceutical formulations comprising denosumab or another human anti-RANKL monoclonal antibody or portion thereof, and characteristics of pH, buffer systems, and amino acid aggregation inhibitors. Also disclosed are presentation of the formulation for use, e.g. in a single-use vial, single-use syringe, or glass container, methods of using the formulations and articles for preventing or treating diseases, and related kits.