公开(公告)号：US20220152154A1

公开(公告)日：2022-05-19

申请号：US17436696

申请日：2020-03-06

Applicant: Amgen Inc.

Inventor： YuMei XIONG ,  Murielle Marie VENIANT ELLISON

IPC: A61K38/18 ,  A61K39/395 ,  A61K38/26 ,  A61K47/68 ,  A61P3/04

Abstract: The present disclosure provides combination therapy with GDF15 molecules. In some embodiments, the GDF15 molecule is a GDF15-Fc fusion, in which a GDF15 region is fused to an Fc region, optionally via a linker. In one embodiment, combination therapy comprises administration of a GDF15 molecule with a GLP-1R agonist. In another embodiment, combination therapy comprises administration of a GDF15 molecule with a GIPR antagonist.

公开(公告)号：US20240327481A1

公开(公告)日：2024-10-03

申请号：US18746427

申请日：2024-06-18

Applicant: AMGEN INC.

Inventor： YuMei XIONG ,  Kenneth William WALKER ,  Murielle Marie VENIANT ELLISON

IPC: C07K14/495 ,  A61K38/00

CPC classification number: C07K14/495 ,  A61K38/00 ,  C07K2319/30

Abstract: GDF15 molecules are provided herein. In some embodiments, the GDF15 molecule is a GDF15-Fc fusion, in which a GDF15 region is fused to an Fc region. In some embodiments, the GDF15 region is fused to the Fc region via a linker. Also, provided herein arr methods for making and using GDF15 molecules.

公开(公告)号：US20220017584A1

公开(公告)日：2022-01-20

申请号：US17494001

申请日：2021-10-05

Applicant: Amgen Inc.

Inventor： YuMei XIONG ,  Kenneth William WALKER ,  Murielle Marie VENIANT ELLISON

IPC: C07K14/495

Abstract: GDF15 molecules are provided herein. In some embodiments, the GDF15 molecule is a GDF15-Fc fusion, in which a GDF15 region is fused to an Fc region. In some embodiments, the GDF15 region is fused to the Fc region via a linker. Also, provided herein are methods for making and using GDF15 molecules.

公开(公告)号：US20240084301A1

公开(公告)日：2024-03-14

申请号：US18357495

申请日：2023-07-24

Applicant: AMGEN INC.

Inventor： Elizabeth Ann KILLION ,  Jerry Ryan HOLDER ,  Bryan MEADE ,  Justin K. MURRAY ,  Oliver R. HOMANN ,  Briana Renee GRIEGO ,  Murielle Marie VENIANT ELLISON

IPC: C12N15/113 ,  A61P1/16 ,  A61P3/04

CPC classification number: C12N15/113 ,  A61P1/16 ,  A61P3/04 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322

Abstract: The present application relates to compositions and methods for modulating expression of Family with Sequence Similarity 13 Member A (FAM13A) protein. In particular, the present application relates to nucleic acid-based therapeutics for reducing FAM13A gene expression via RNA interference and methods of using such nucleic acid-based therapeutics to reduce abdominal adiposity, reduce body weight, reduce fat mass, improve metabolic parameters including insulin resistance and non-alcoholic steatohepatitis (NASH), and reduce risk of myocardial infarction.

公开(公告)号：US20230143988A1

公开(公告)日：2023-05-11

申请号：US16620029

申请日：2019-04-08

Applicant: Amgen Inc.

Inventor： YuMei XIONG ,  Kenneth William WALKER ,  Murielle Marie VENIANT ELLISON

IPC: C07K14/495

CPC classification number: C07K14/495 ,  C07K2319/30

Abstract: GDF15 molecules are provided herein. In some embodiments, the GDF15 molecule is a GDF15-Fc fusion, in which a GDF15 region is fused to an Fc region. In some embodiments, the GDF15 region is fused to the Fc region via a linker. Also, provided herein are methods for making and using GDF15 molecules.

公开(公告)号：US20210147500A1

公开(公告)日：2021-05-20

申请号：US17148761

申请日：2021-01-14

Applicant: Amgen Inc.

Inventor： YuMei XIONG ,  Kenneth William WALKER ,  Murielle Marie VENIANT ELLISON

IPC: C07K14/495

Abstract: GDF15 molecules are provided herein. In some embodiments, the GDF15 molecule is a GDF15-Fc fusion, in which a GDF15 region is fused to an Fc region. In some embodiments, the GDF15 region is fused to the Fc region via a linker. Also, provided herein are methods for making and using GDF15 molecules.