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公开(公告)号：US20210301020A1
公开(公告)日：2021-09-30
申请号：US17262339
申请日：2019-07-17
Applicant: AMGEN INC.
Inventor： Xin YU , Wenjun OUYANG , Chi-Ming Kevin LI , Jackson Graeme EGEN , Oh Kyu YOON , Ian Halsey DRIVER , Shunsuke TAKENAKA , Christy Ann THOMSON , Hongyu WANG
Abstract: This invention relates to combination therapies comprising a Programmed Death 1 receptor (PD-1) pathway inhibitor, and a Leukocyte Immunoglobulin Like Receptor B (LILRB) signaling inhibitor, and the use of the combination therapies for the treatment of cancer. The invention also relates to the treatment of cancer patients who are refractory to monotherapy with a PD-1 pathway inhibitor.
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公开(公告)号：US20210108212A1
公开(公告)日：2021-04-15
申请号：US17080771
申请日：2020-10-26
Applicant: AMGEN INC.
Inventor： Michael OLLMANN , Yang LI , Jun ZHANG , Kaustav BISWAS , Oliver HOMANN , Leslie P. MIRANDA , Justin K. MURRAY , Bin WU , Oh Kyu YOON , John Gordon ALLEN , Chawita NETIROJJANAKUL , Yuan CHENG
IPC: C12N15/113 , A61P9/10 , A61P3/06 , C07K16/28
Abstract: The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.
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公开(公告)号：US20190309306A1
公开(公告)日：2019-10-10
申请号：US16328221
申请日：2017-08-25
Applicant: AMGEN INC.
Inventor： Michael OLLMANN , Yang LI , Jun ZHANG , Kaustav BISWAS , Oliver HOMANN , Leslie P. MIRANDA , Justin K. MURRAY , Bin WU , Oh Kyu YOON , John Gordon ALLEN , Chawita NETIROJJANAKUL , Yuan CHENG
IPC: C12N15/113 , A61P3/06 , A61P9/10 , C07K16/28
Abstract: The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.
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