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公开(公告)号：US20230078200A1
公开(公告)日：2023-03-16
申请号：US17783232
申请日：2020-12-08
申请人： AMGEN INC.
发明人： Bin WU , Michael OLLMANN , Oliver HOMANN , Yuan CHENG
IPC分类号： C12N15/113 , A61P9/10
摘要： The present invention relates to RNAi constructs for reducing expression of the LPA gene, which encodes apolipoprotein(a), a component of lipoprotein(a) (Lp(a)) particles. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease, peripheral artery disease, stroke, and myocardial infarction, and to reduce serum Lp(a) levels are also described.
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公开(公告)号：US20220340911A1
公开(公告)日：2022-10-27
申请号：US17634708
申请日：2020-08-13
申请人： AMGEN INC.
发明人： Wei GU , Essa Hu HARRINGTON , Oliver HOMANN
IPC分类号： C12N15/113 , C12N15/10 , A61K47/00
摘要： The present invention relates to RNAi constructs for reducing expression of the SLC30A8 gene. Methods of using such RNAi constructs to treat or prevent disease, such as pre-diabetes or diabetes are also described.
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公开(公告)号：US20210139912A1
公开(公告)日：2021-05-13
申请号：US16771907
申请日：2018-12-12
申请人： AMGEN INC.
IPC分类号： C12N15/113 , A61K31/7105
摘要： The present invention relates to RNAi constructs for reducing expression of the PNPLA3 gene. Methods of using such RNAi constructs to treat or prevent liver disease, nonalcoholic fatty liver disease (NAFLD) are also described.
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公开(公告)号：US20230279399A1
公开(公告)日：2023-09-07
申请号：US18007560
申请日：2021-06-03
申请人： Amgen Inc.
发明人： Daniel C. H. LIN , Michael OLLMANN , Justin K. MURRAY , Bradley J. HERBERICH , Amrita DAS , Patrick COLLINS , Oliver HOMANN
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , C12N2310/321 , C12N2310/322 , C12N2310/315 , C12N2310/11
摘要： The present invention relates to RNAi constructs for reducing expression of the HSD17B13 gene. Methods of using such RNAi constructs to treat or prevent liver disease, nonalcoholic fatty liver disease (NAFLD) are also described.
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公开(公告)号：US20220307022A1
公开(公告)日：2022-09-29
申请号：US17615520
申请日：2020-06-01
申请人： AMGEN INC.
发明人： Amrita DAS , Bradley J. HERBERICH , Justin K. MURRAY , Oliver HOMANN , Michael OLLMANN , Daniel C.H. LIN
IPC分类号： C12N15/113 , A61K31/713 , A61K31/7105
摘要： The present invention relates to RNAi constructs for reducing expression of the SCAP gene. Methods of using such RNAi constructs to treat or prevent liver disease, nonalcoholic fatty liver disease (NAFLD) are also described.
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公开(公告)号：US20220017906A1
公开(公告)日：2022-01-20
申请号：US17312721
申请日：2019-12-10
申请人： Amgen Inc.
IPC分类号： C12N15/113
摘要： The present invention relates to RNAi constructs for reducing expression of the PNPLA3 gene. Methods of using such RNAi constructs to treat or prevent liver disease, nonalcoholic fatty liver disease (NAFLD) are also described.
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公开(公告)号：US20210108212A1
公开(公告)日：2021-04-15
申请号：US17080771
申请日：2020-10-26
申请人： AMGEN INC.
发明人： Michael OLLMANN , Yang LI , Jun ZHANG , Kaustav BISWAS , Oliver HOMANN , Leslie P. MIRANDA , Justin K. MURRAY , Bin WU , Oh Kyu YOON , John Gordon ALLEN , Chawita NETIROJJANAKUL , Yuan CHENG
IPC分类号： C12N15/113 , A61P9/10 , A61P3/06 , C07K16/28
摘要： The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.
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公开(公告)号：US20190309306A1
公开(公告)日：2019-10-10
申请号：US16328221
申请日：2017-08-25
申请人： AMGEN INC.
发明人： Michael OLLMANN , Yang LI , Jun ZHANG , Kaustav BISWAS , Oliver HOMANN , Leslie P. MIRANDA , Justin K. MURRAY , Bin WU , Oh Kyu YOON , John Gordon ALLEN , Chawita NETIROJJANAKUL , Yuan CHENG
IPC分类号： C12N15/113 , A61P3/06 , A61P9/10 , C07K16/28
摘要： The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.
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