公开(公告)号：US08980256B2

公开(公告)日：2015-03-17

申请号：US13678407

申请日：2012-11-15

Applicant: Amgen Inc.

Inventor： Tiansheng Li ,  Christopher James Sloey

IPC: A61K39/00 ,  C07K16/00 ,  A61K9/19 ,  A61K47/10 ,  A61K9/00 ,  A61K38/18 ,  A61K38/19 ,  A61K39/395 ,  A61K47/02 ,  A61K47/18 ,  A61K47/26

CPC classification number: A61K47/10 ,  A61K9/0019 ,  A61K9/19 ,  A61K38/1816 ,  A61K38/193 ,  A61K39/39533 ,  A61K39/39591 ,  A61K47/02 ,  A61K47/18 ,  A61K47/183 ,  A61K47/186 ,  A61K47/26 ,  A61K2039/505

Abstract: A method of stabilizing an aqueous protein or antibody formulation is disclosed herein. Additionally, stable pharmaceutical formulations are contemplated which comprise a biologically active protein, a destabilizing concentration of preservative and a stabilizing concentration of osmolyte.

Abstract translation: 本文公开了稳定水性蛋白质或抗体制剂的方法。 此外，涵盖稳定的药物制剂，其包含生物活性蛋白质，去稳定浓度的防腐剂和稳定的渗透液浓度。

公开(公告)号：US20130121990A1

公开(公告)日：2013-05-16

申请号：US13742818

申请日：2013-01-16

Applicant: Amgen Inc.

Inventor： Christopher James Sloey ,  Camille Vergara ,  Jason Ko ,  Tiansheng Li

IPC: A61K47/22 ,  A61K47/18

CPC classification number: A61K47/24 ,  A61K9/0019 ,  A61K9/19 ,  A61K39/395 ,  A61K47/18 ,  A61K47/183 ,  A61K47/186 ,  A61K47/22

Abstract: A stable pharmaceutical formulation is provided that comprises a biologically active protein and an excipient selected from carnitine, creatine or creatinine.

Abstract translation: 提供了稳定的药物制剂，其包含生物活性蛋白质和选自肉碱，肌酸或肌酸酐的赋形剂。

公开(公告)号：US20200276313A1

公开(公告)日：2020-09-03

申请号：US16878385

申请日：2020-05-19

Applicant: AMGEN INC.

Inventor： Christopher James Sloey ,  Camille Vergara ,  Jason Ko ,  Tiansheng Li

IPC: A61K47/24 ,  A61K9/19 ,  A61K47/18 ,  A61K47/22 ,  A61K39/395

Abstract: A stable pharmaceutical formulation is provided that comprises a biologically active protein and an excipient selected from caritine, creatine or creatinine.

公开(公告)号：US10653781B2

公开(公告)日：2020-05-19

申请号：US15089036

申请日：2016-04-01

Applicant: AMGEN INC.

Inventor： Christopher James Sloey ,  Camille Gleason ,  Jason Ko ,  Tiansheng Li

IPC: A61K39/395 ,  A61K47/24 ,  A61K9/19 ,  A61K47/18 ,  A61K47/22 ,  A61K9/00

Abstract: A stable pharmaceutical formulation is provided that comprises a biologically active protein and an excipient selected from carnitine, creatine or creatinine.

公开(公告)号：US20170049895A1

公开(公告)日：2017-02-23

申请号：US15089036

申请日：2016-04-01

Applicant: AMGEN INC.

Inventor： Christopher James Sloey ,  Camille Gleason ,  Jason Ko ,  Tiansheng Li

IPC: A61K47/24 ,  A61K47/18 ,  A61K47/22 ,  A61K39/395 ,  A61K9/19

CPC classification number: A61K47/24 ,  A61K9/0019 ,  A61K9/19 ,  A61K39/395 ,  A61K47/18 ,  A61K47/183 ,  A61K47/186 ,  A61K47/22

Abstract: A stable pharmaceutical formulation is provided that comprises a biologically active protein and an excipient selected from carnitine, creatine or creatinine.

Abstract translation: 提供了稳定的药物制剂，其包含生物活性蛋白质和选自肉碱，肌酸或肌酸酐的赋形剂。

公开(公告)号：US20230126688A1

公开(公告)日：2023-04-27

申请号：US17929232

申请日：2022-09-01

Applicant: AMGEN INC.

Inventor： Christopher James Sloey ,  Jason Ko ,  Tiansheng Li

IPC: A61K47/12 ,  A61K47/22 ,  A61K39/395 ,  A61K9/00 ,  A61K38/18

Abstract: The present invention relates to stable aqueous protein formulations. In particular, disclosed herein are therapeutic protein formulations suitable for parenteral administration having one or more antioxidants.

公开(公告)号：US10668154B2

公开(公告)日：2020-06-02

申请号：US14613501

申请日：2015-02-04

Applicant: AMGEN INC.

Inventor： Tiansheng Li ,  Christopher James Sloey

IPC: A61K38/18 ,  A61K9/14 ,  C07K14/475 ,  C07K1/30 ,  A61K47/10 ,  A61K39/395 ,  A61K9/00 ,  A61K9/19 ,  A61K38/19 ,  A61K47/02 ,  A61K47/18 ,  A61K47/26 ,  A61K39/00

Abstract: A method of stabilizing an aqueous protein or antibody formulation is disclosed herein. Additionally, stable pharmaceutical formulations are contemplated which comprise a biologically active protein, a destabilizing concentration of preservative and a stabilizing concentration of osmolyte.

公开(公告)号：US09320797B2

公开(公告)日：2016-04-26

申请号：US13742818

申请日：2013-01-16

Applicant: AMGEN INC.

Inventor： Christopher James Sloey ,  Camille Vergara ,  Jason Ko ,  Tiansheng Li

IPC: A61K39/395 ,  A61K47/22 ,  A61K9/19 ,  A61K47/18 ,  A61K9/00

CPC classification number: A61K47/24 ,  A61K9/0019 ,  A61K9/19 ,  A61K39/395 ,  A61K47/18 ,  A61K47/183 ,  A61K47/186 ,  A61K47/22

Abstract: A stable pharmaceutical formulation is provided that comprises a biologically active protein and an excipient selected from carnitine, creatine or creatinine.