公开(公告)号：US11433110B2

公开(公告)日：2022-09-06

申请号：US16651880

申请日：2018-08-20

Applicant: AMOREPACIFIC CORPORATION

Inventor： Hyoung-June Kim ,  Tae Ryong Lee

IPC: A61K36/00 ,  A61K36/185 ,  A23L33/105 ,  A61K8/9789 ,  A61Q19/00

Abstract: Disclosed is a composition including a Hibiscus syriacus extract as an effective ingredient for treating fine dust-caused skin damage, wherein the expression of at least one selected from the group consisting of IL-36G (NM_019618), PTGS2 (NM_000963), XDH (NM_000379) and S100A7 (NM_002963), which are all genes having the expression levels affected by fine dust in skin cells, is regulated to a normal level and for inhibiting an antibacterial peptide, wherein the expression of the antibacterial peptide S100A7 (NM_002963) is regulated to a normal level. By using the composition for treating fine dust-caused skin damage and the composition for inhibiting an antibacterial peptide, gene expression changed by fine dust can return to a normal level to treat skin cell damage and the increased expression of the antibacterial peptide due to various causes can return to normal level.

公开(公告)号：US11666620B2

公开(公告)日：2023-06-06

申请号：US16766158

申请日：2018-11-22

Applicant: AMOREPACIFIC CORPORATION

Inventor： Yeongran Lee ,  Hyoung-June Kim ,  Jun Seong Park ,  Kyeonghwan Hwang

IPC: A61K36/82 ,  A23L33/105 ,  A61K8/9789 ,  A61K8/60 ,  A61K31/704 ,  A61Q19/08

CPC classification number: A61K36/82 ,  A23L33/105 ,  A61K8/602 ,  A61K8/9789 ,  A61K31/704 ,  A61Q19/08 ,  A23V2002/00

Abstract: The present specification discloses a composition for external application to skin, containing a tea plant root extract as an active ingredient, for treatment of skin damage caused by fine dust, whereby the expression level of one or more selected from a group consisting of IL-36G (NM_019618), S100A7 (NM_002963), S100A8 (NM_002964) and XDH (NM_000379), which are genes in skin cells the expression level of which is affected by fine dust, is regulated to a normal level.