公开(公告)号：US10858315B2

公开(公告)日：2020-12-08

申请号：US16337729

申请日：2017-09-26

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byoung Young Woo ,  Ki-Wha Lee ,  Jihae Lee ,  Chang Soon Choi ,  Miyoung Park ,  Young-Ho Park ,  Sarva Jayaprakash ,  Sridhar Regati ,  Mamidi Srinivas ,  Krushnakant Patel ,  M. Ramamohan

IPC: C07C311/08 ,  B01D9/00 ,  C07C303/44 ,  B01L9/00

Abstract: Disclosed in the present specification is a method capable of preparing N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide (INT028-2) with high optical purity, through the selection of Ellman-chiral auxiliaries and the recrystallization and separation of optical isomers. According to the above method, high-purity N-[4-[(1R)-1-[[(R)-(1,1-dimethylethyl)sulfinyl]amino]ethyl]-2,6-difluorophenyl]-methanesulfonamide with excellent quality can be produced at room temperature by improving cryogenic process conditions necessary for realizing high optical purity, and thus the trimming due to the process failure rate can be remarkably reduced.