公开(公告)号：US12257278B2

公开(公告)日：2025-03-25

申请号：US17259849

申请日：2019-07-12

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Douglas Grant McFadden ,  John Christie ,  Joseph Blattman ,  Mohammed Masmudur Rahman ,  Nancy Yaneth Villa

IPC: A61K35/768 ,  A61K35/14 ,  A61K35/28 ,  A61K45/06 ,  A61P35/00 ,  C07K14/525

Abstract: Disclosed herein, in certain embodiments, is a method of inhibiting or treating a cancer with use of a TNF expressing myxoma virus. Also disclosed herein are methods of inhibiting or treating a cancer with use of a mononuclear peripheral blood cells and/or a bone marrow cells treated with a TNF-expressing myxoma virus. Some aspects relate to engineered myxoma virus and pharmaceutical compositions for use with one or more of the methods described herein.