公开(公告)号：US10745478B2

公开(公告)日：2020-08-18

申请号：US15999241

申请日：2017-02-17

Applicant: Dignity Health ,  Arizona Board of Regents on behalf of Arizona State University

Inventor： Rachael Sirianni ,  Rebecca Cook ,  Tsafrir Mor ,  Joseph Blattman

IPC: C07K16/28 ,  A61K47/68 ,  C12N15/82 ,  A61P35/00 ,  A61K9/00 ,  C12N15/74 ,  C12N15/86 ,  A61K39/00

Abstract: Disclosed herein are compositions comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell. Also disclosed herein are methods of treating cancer in a subject, comprising: providing a composition comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell; and treating the cancer by administering a therapeutically effective dosage of the composition to the subject.

公开(公告)号：US12018317B2

公开(公告)日：2024-06-25

申请号：US17546953

申请日：2021-12-09

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Joseph Blattman ,  Louis Schoettle

IPC: C12Q1/68 ,  C12N15/87 ,  C12Q1/6806 ,  C12Q1/6869

CPC classification number: C12Q1/6806 ,  C12N15/87 ,  C12Q1/6869 ,  C12Q1/6869 ,  C12Q2563/159 ,  C12Q2563/179 ,  C12Q2565/133

Abstract: Methods for incorporation of unique bowtie-barcodes into a nucleic acid origami nanostructure (FIG. 1). In particular, provided herein are methods that facilitate pairing and analysis of nucleic acids from individual cells using, for example, high-throughput next-generation sequencing.

公开(公告)号：US11807661B2

公开(公告)日：2023-11-07

申请号：US16929001

申请日：2020-07-14

Applicant: Dignity Health ,  Arizona Board of Regents on Behalf of Arizona State University

Inventor： Rachael Sirianni ,  Rebecca Cook ,  Tsafrir Mor ,  Joseph Blattman

IPC: A61K35/00 ,  C07K16/28 ,  A61K47/68 ,  C12N15/82 ,  A61P35/00 ,  A61K9/00 ,  C12N15/86 ,  C12N15/74 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K9/0019 ,  A61K47/6817 ,  A61P35/00 ,  C07K16/2809 ,  C12N15/743 ,  C12N15/8258 ,  C12N15/86 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2319/33 ,  C07K2319/55

Abstract: Disclosed herein are compositions comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell. Also disclosed herein are methods of treating cancer in a subject, comprising: providing a composition comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell; and treating the cancer by administering a therapeutically effective dosage of the composition to the subject.

公开(公告)号：US20180216102A1

公开(公告)日：2018-08-02

申请号：US15937371

申请日：2018-03-27

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Joseph Blattman ,  Hao Yan ,  Louis Schoettle ,  Xixi Wei

IPC: C12N15/10 ,  C12Q1/6806

CPC classification number: C12N15/1062 ,  B82Y5/00 ,  B82Y15/00 ,  C12Q1/6806 ,  C12Q1/6816 ,  C12Q1/6881 ,  C12Q2600/16 ,  C12Q2563/155

Abstract: Methods for construction of DNA origami nanostructures, as well as for binding, isolation, linking, and deep sequencing information, such as both of TCR alpha and beta CDR3 mRNA, from individual cells within a mixed population of cells without the need for single cell sorting (FIG. 1).

公开(公告)号：US20220162674A1

公开(公告)日：2022-05-26

申请号：US17546953

申请日：2021-12-09

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Joseph Blattman ,  Louis Schoettle

IPC: C12Q1/6806 ,  C12Q1/6869 ,  C12N15/87

Abstract: Methods for incorporation of unique bowtie-barcodes into a nucleic acid origami nanostructure (FIG. 1). In particular, provided herein are methods that facilitate pairing and analysis of nucleic acids from individual cells using, for example, high-throughput next-generation sequencing.

公开(公告)号：US20200339679A1

公开(公告)日：2020-10-29

申请号：US16929001

申请日：2020-07-14

Applicant: Dignity Health ,  Arizona Board of Regents on Behalf of Arizona State University

Inventor： Rachael Sirianni ,  Rebecca Cook ,  Tsafrir Mor ,  Joseph Blattman

IPC: C07K16/28 ,  A61K47/68 ,  C12N15/82 ,  A61P35/00 ,  A61K9/00 ,  C12N15/74 ,  C12N15/86

Abstract: Disclosed herein are compositions comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell. Also disclosed herein are methods of treating cancer in a subject, comprising: providing a composition comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell; and treating the cancer by administering a therapeutically effective dosage of the composition to the subject.

公开(公告)号：US12257278B2

公开(公告)日：2025-03-25

申请号：US17259849

申请日：2019-07-12

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Douglas Grant McFadden ,  John Christie ,  Joseph Blattman ,  Mohammed Masmudur Rahman ,  Nancy Yaneth Villa

IPC: A61K35/768 ,  A61K35/14 ,  A61K35/28 ,  A61K45/06 ,  A61P35/00 ,  C07K14/525

Abstract: Disclosed herein, in certain embodiments, is a method of inhibiting or treating a cancer with use of a TNF expressing myxoma virus. Also disclosed herein are methods of inhibiting or treating a cancer with use of a mononuclear peripheral blood cells and/or a bone marrow cells treated with a TNF-expressing myxoma virus. Some aspects relate to engineered myxoma virus and pharmaceutical compositions for use with one or more of the methods described herein.

公开(公告)号：US20240092894A1

公开(公告)日：2024-03-21

申请号：US18480038

申请日：2023-10-03

Applicant: Dignity Health ,  Arizona Board of Regents on Behalf of Arizona State University

Inventor： Rachael Sirianni ,  Rebecca Cook ,  Tsafrir Mor ,  Joseph Blattman

IPC: C07K16/28 ,  A61K9/00 ,  A61K47/68 ,  A61P35/00 ,  C12N15/74 ,  C12N15/82 ,  C12N15/86

CPC classification number: C07K16/28 ,  A61K9/0019 ,  A61K47/6817 ,  A61P35/00 ,  C07K16/2809 ,  C12N15/743 ,  C12N15/8258 ,  C12N15/86 ,  A61K2039/505 ,  C07K2317/622

Abstract: Disclosed herein are compositions comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell. Also disclosed herein are methods of treating cancer in a subject, comprising: providing a composition comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer cell; and treating the cancer by administering a therapeutically effective dosage of the composition to the subject.

公开(公告)号：US11466267B2

公开(公告)日：2022-10-11

申请号：US15937371

申请日：2018-03-27

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Joseph Blattman ,  Hao Yan ,  Louis Schoettle ,  Xixi Wei

IPC: C12Q1/68 ,  C12N15/10 ,  C12Q1/6816 ,  C12Q1/6881 ,  C12Q1/6806 ,  B82Y5/00 ,  B82Y15/00

Abstract: Methods for construction of DNA origami nanostructures, as well as for binding, isolation, linking, and deep sequencing information, such as both of TCR alpha and beta CDR3 mRNA, from individual cells within a mixed population of cells without the need for single cell sorting (FIG. 1).

公开(公告)号：US11208681B2

公开(公告)日：2021-12-28

申请号：US16320962

申请日：2017-08-14

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Joseph Blattman ,  Louis Schoettle

IPC: C12Q1/68 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12N15/87

Abstract: Methods for incorporation of unique bowtie-barcodes into a nucleic acid origami nanostructure (FIG. 1). In particular, provided herein are methods that facilitate pairing and analysis of nucleic acids from individual cells using, for example, high-throughput next-generation sequencing.