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公开(公告)号：US20230384313A1
公开(公告)日：2023-11-30
申请号：US18322442
申请日：2023-05-23
发明人： Joshua LaBaer , Ji Qiu , Lusheng Song , Yunro Chung
IPC分类号： G01N33/574
CPC分类号： G01N33/57446 , G01N2333/205 , G01N2800/52 , G01N2800/50
摘要： Provided are methods and compositions for identifying individuals having intestinal metaplasia (IM) and/or Helicobacter pylori infection based on the levels of antibodies against particular Helicobacter pylori antigens. Patient diagnosis allows for medical interventions, including therapeutic treatments, disease progression preventative measures and enhanced cancer screening. Also provided are methods and compositions for identifying individuals having IM who are at increased risk for developing gastric cancer. Patient diagnosis and stratification by risk allows for targeted screening and monitoring for signs of gastric cancer as well as earlier intervention with cancer preventative treatments.
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公开(公告)号：US20220373548A1
公开(公告)日：2022-11-24
申请号：US17771595
申请日：2020-10-23
发明人： Joshua LaBaer , Lusheng Song , Ji Qiu , Yunro Chung
IPC分类号： G01N33/569 , G01N33/574 , A61P35/00
摘要： Provided herein are methods, compositions, kits, and systems for detecting Epstein Barr virus infection (EBV) in gastric cancer (GC) patients. In particular, provided herein are methods, composition, kits, and systems for diagnosing and treating EBV-positive gastric cancer (EBV+ GC) in a biological sample of an individual based on the presence and level of antibodies against particular Epstein Barr virus proteins. EBV+ GC is a distinct subtype of gastric cancer and is associated with unique molecular profiles. Also provided herein are methods for providing more personalized therapy for each of these distinct cancer subtypes and methods for determining an Epstein Barr virus-positive gastric cancer antibody signature, and kits comprising components and protocols for performing the methods of this disclosure.
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