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公开(公告)号：US20190062728A1
公开(公告)日：2019-02-28
申请号：US15748946
申请日：2016-09-13
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： Joshua Labaer , Kevin Gorman , Brian Kay , Jie Wang , Ji Qiu
IPC分类号： C12N15/10
摘要： Methods for screening of affinity reagents for many target proteins of interest simultaneously. Arrayed targets (e.g., peptide, protein, RNA, cell, etc.) are used in affinity selection experiments to reduce the amount of target needed and to improve the throughput of discovering recombinant affinity reagents to a large collection of targets.
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公开(公告)号：US20170363631A1
公开(公告)日：2017-12-21
申请号：US15534203
申请日：2015-12-09
发明人： Joshua LaBaer , Jie Wang , Ji Qiu , Garrick Wallstrom , Karen Anderson , Jin Park , Jonine Figueroa
IPC分类号： G01N33/574 , C12Q1/68 , C07K16/30 , C12N15/11
CPC分类号： G01N33/57415 , C07K16/3015 , C12N15/11 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/564
摘要： Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).
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公开(公告)号：US12085569B2
公开(公告)日：2024-09-10
申请号：US17940883
申请日：2022-09-08
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Joshua LaBaer , Jie Wang , Ji Qiu , Garrick Wallstrom , Karen Anderson , Jin Park , Jonine Figueroa
IPC分类号： G01N33/574 , C07K16/30 , C12Q1/6886 , G01N33/564 , C12N15/11
CPC分类号： G01N33/57415 , C07K16/3015 , C12Q1/6886 , G01N33/564 , C12N15/11 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).
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公开(公告)号：US11913138B2
公开(公告)日：2024-02-27
申请号：US17405172
申请日：2021-08-18
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： Joshua Labaer , Kevin Gorman , Brian Kay , Jie Wang , Ji Qiu
IPC分类号： C40B30/04 , C12N15/10 , C12Q1/6811
CPC分类号： C40B30/04 , C12N15/1037 , C12N15/1041 , C12N15/1062 , C12Q1/6811 , C12Q1/6811 , C12Q2565/501 , C12Q2565/515
摘要： Methods for screening of affinity reagents for many target proteins of interest simultaneously. Arrayed targets (e.g., peptide, protein, RNA, cell, etc.) are used in affinity selection experiments to reduce the amount of target needed and to improve the throughput of discovering recombinant affinity reagents to a large collection of targets.
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公开(公告)号：US20230384313A1
公开(公告)日：2023-11-30
申请号：US18322442
申请日：2023-05-23
发明人： Joshua LaBaer , Ji Qiu , Lusheng Song , Yunro Chung
IPC分类号： G01N33/574
CPC分类号： G01N33/57446 , G01N2333/205 , G01N2800/52 , G01N2800/50
摘要： Provided are methods and compositions for identifying individuals having intestinal metaplasia (IM) and/or Helicobacter pylori infection based on the levels of antibodies against particular Helicobacter pylori antigens. Patient diagnosis allows for medical interventions, including therapeutic treatments, disease progression preventative measures and enhanced cancer screening. Also provided are methods and compositions for identifying individuals having IM who are at increased risk for developing gastric cancer. Patient diagnosis and stratification by risk allows for targeted screening and monitoring for signs of gastric cancer as well as earlier intervention with cancer preventative treatments.
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公开(公告)号：US20230079737A1
公开(公告)日：2023-03-16
申请号：US17940883
申请日：2022-09-08
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Joshua LaBaer , Jie Wang , Ji Qiu , Garrick Wallstrom , Karen Anderson , Jin Park , Jonine Figueroa
IPC分类号： G01N33/574 , G01N33/564 , C07K16/30 , C12Q1/6886
摘要： Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).
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公开(公告)号：US20210380970A1
公开(公告)日：2021-12-09
申请号：US17405172
申请日：2021-08-18
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： Joshua Labaer , Kevin Gorman , Brian Kay , Jie Wang , Ji Qiu
IPC分类号： C12N15/10 , C12Q1/6811
摘要： Methods for screening of affinity reagents for many target proteins of interest simultaneously. Arrayed targets (e.g., peptide, protein, RNA, cell, etc.) are used in affinity selection experiments to reduce the amount of target needed and to improve the throughput of discovering recombinant affinity reagents to a large collection of targets.
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公开(公告)号：US11124791B2
公开(公告)日：2021-09-21
申请号：US15748946
申请日：2016-09-13
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： Joshua Labaer , Kevin Gorman , Brian Kay , Jie Wang , Ji Qiu
IPC分类号： C40B30/04 , C12N15/10 , C12Q1/6811
摘要： Methods for screening of affinity reagents for many target proteins of interest simultaneously. Arrayed targets (e.g., peptide, protein, RNA, cell, etc.) are used in affinity selection experiments to reduce the amount of target needed and to improve the throughput of discovering recombinant affinity reagents to a large collection of targets.
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公开(公告)号：US20190004051A1
公开(公告)日：2019-01-03
申请号：US16069111
申请日：2017-01-11
发明人： Joshua Labaer , Ji Qiu , Jie Wang , Garrick Wallstrom , Jin Park , William Rom , Harvey Pass
IPC分类号： G01N33/574
摘要： An immune-proteomic screening of AAb responses using protein arrays has identified two panels of Aab (antigen/antibody complexes) that can potentially differentiate lung adenocarcinoma from smoker controls as well as CT positive benign lung disease. The resulting biomarkers appear to have high specificity so that high risk subjects with a positive CT screen and a positive serum test should get more invasive test such as needle biopsy for a timely cancer diagnosis, among other advantages.
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公开(公告)号：US20180224448A1
公开(公告)日：2018-08-09
申请号：US15892981
申请日：2018-02-09
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： Haoyu Wang , Ji Qiu , Joshua LaBaer , Jonathan Leighton , Shabana Pasha
IPC分类号： G01N33/564 , G01N33/50 , G01N33/52 , G01N33/543 , C12N15/10 , C07K16/18
CPC分类号： G01N33/564 , C07K16/18 , C07K16/30 , C07K16/3069 , C07K16/40 , C07K2317/30 , C12N15/1065 , C12N2310/3519 , G01N33/5023 , G01N33/521 , G01N33/54353 , G01N33/5436 , G01N33/54393 , G01N2800/065
摘要： Identification of autoantibodies associated with Crohn's disease useful in diagnosis and management using an innovative protein array technology, namely nucleic acid programmable protein arrays (NAPPA) and applications relating thereto. Overall, reactivity of IgG autoantibodies was stronger than that of IgA autoantibodies; however, IgA autoantibodies showed greater differential reactivity between cases and controls. Four IgA autoantibodies against SNRPB, PRPH, PTTG1 and SNAI1 were newly identified with sensitivities above 15% at 95% specificity, among which anti-SNRPB-IgA had the highest sensitivity of 24.0%. Autoantibodies associated with specific disease subtypes were also found.
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