公开(公告)号：US20200318054A1

公开(公告)日：2020-10-08

申请号：US16908515

申请日：2020-06-22

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

发明人： Joel L. Cuello ,  Jack Welchert ,  Andres P. Mayol ,  Mark Jendrisak

IPC分类号： C12M1/00 ,  C12N5/00 ,  C12M1/04 ,  B01F13/02 ,  B01F7/00 ,  B01F7/22

摘要： An air-stirred tank reactor (ASTR) and methods of use thereof are described herein. The ASTR is equipped with an impeller or set of impellers that mechanically mixes a liquid culture, as well as sparges gas into the liquid medium. The impeller can further have lighting sources that can illuminate the liquid culture. Unlike conventional bioreactors, the ASTR provides superior liquid mixing, efficient gas mass transfer, and a low-shear culture environment through appropriate impeller rotational speed and sparging rate.