公开(公告)号：US3758576A

公开(公告)日：1973-09-11

申请号：US3758576D

申请日：1970-06-15

Applicant: ASAHI CHEMICAL IND

Inventor： TAKAHASHI Y ,  FUKUOKA Y

IPC: C07C233/00 ,  C07C103/08

CPC classification number: C07C233/00

Abstract: N,N-dialkyl carboxylic acid amides are prepared by reacting a primary amine, second amine or tertiary amine, or a mixture thereof, with a nitrile at elevated temperatures and pressures, with or without the use of a catalyst.

Abstract translation: 通过使用或不使用催化剂，在升高的温度和压力下使伯胺，第二胺或叔胺或其混合物与腈反应制备N，N-二烷基羧酸酰胺。

公开(公告)号：US3751465A

公开(公告)日：1973-08-07

申请号：US3751465D

申请日：1970-12-22

Applicant: ASAHI CHEMICAL IND

Inventor： SASAKI K ,  SENOO S ,  TAKAHASHI Y ,  FUKUOKA Y

IPC: C07C231/06 ,  C07C20060101 ,  C07C103/08

CPC classification number: C07C231/06 ,  C07C233/05 ,  C07C233/03

Abstract: NOVEL PROCESS FOR THE PREPARATION OF N,N-DIALKYL-SUBSTITUTED FATTY AMIDES REPRESENTED BY THE GENERAL FORMULA

R-CO-N(-R'')2

WHEREIN R IS AN ALKYL RADICAL HAVING 1 TO 6 CARBON ATOMS AND R'' IS AN ALKYL RADICAL HAVING 1 TO 4 CARBON ATOMS, WHICH COMPRISES REACTING AT A TEMPERATURE IN THE RANGE OF 50 TO 1000*C. UNDER PRESSURE A NITRILE REPRESENTED BY THE GENERAL FORMULA R-CN, WHEREIN R HAS THE SAME MEANING AS DEFINED ABOVE, WITH AN ALCOHOL REPRESENTED BY THE GENERAL FORMULA R''-OH, WHEREIN R'' HAS THE SAME MEANING AS DEFINED ABOVE, THE ALCOHOL BEING EMPLOYED IN AN AMOUNT IN THE RANGE OF FROM 1.5 TO 10 MOLES OF ALCOHOL PER MOLE OF THE NITRILE, WITH OR WITHOUT EMPLOYING A CATALYST, AND RECYCLING AT LEAST A PART OF THE BY-PRODUCTS OF THE REACTION TO THE STARTING REACTION MIXTURE. THEREBY, THE N,N-DIALKYLAMIDES CAN BE PRODUCED IN HIGH YIELD. AND, A NOVEL PROCESS FOR THE PREPARATION OF N,N-DIALKYLFORMAMIDES REPRESENTED BY THE GENERAL FORMULA

(R'')2-N-CO-H

WHEREIN R'' IS AN ALKYL RADICAL HAVING 1 TO 4 CARBON ATOMS, WHICH COMPRISES REACTING AT A TEMPERATURE IN THE RANGE OF 50 TO 1000*C. UNDER PRESSURE HYDROGEN CYANIDE, WHICH IS UTTERLY DIFFERENT IN CHEMICAL BEHAVIOR FROM THE NITRILE, WITH AN ALCOHOL REPRESENTED BY THE GENERAL FORMULA R''-OH, WHEREIN R'' HAS THE SAME MEANING AS DEFINED ABOVE, THE ALCOHOL BEING EMPLOYED IN AN AMOUNT IN THE RANGE FROM 1.5 TO 10 MOLES OF ALCOHOL PER MOLE OF THE HYDROGEN CYANIDE, WITH OR WITHOUT EMPLOYING A CATALYST. IN THE LATTER PROCESS ALSO, THE YIELD MAY ADVANTAGEOUSLY BE IMPROVED BY RECYCLING AT LEAST A PART OF THE BY-PRODUCTS OF THE REACTION.

公开(公告)号：US3767644A

公开(公告)日：1973-10-23

申请号：US3767644D

申请日：1971-12-27

Applicant: ASAHI CHEMICAL IND

Inventor： FUKUOKA Y ,  SASAKI K

IPC: C07D223/10 ,  B01J27/00 ,  C07B61/00 ,  C07D201/08 ,  C07D207/27 ,  C07D211/76 ,  C07D41/06

CPC classification number: C07D201/08

Abstract: AN IMPROVED PROCESS FOR THE PREPARATION OF N-ALKYL SUBSTITUTED LACTAMS USEFUL AS SOLVENTS BY HEATING A CYANHYDRIN REPRESENTED BY THE FORMULA HO(CH2)NCN WHEREIN N IS AN INTEGER OF 3 TO 5 INCLUSIVE TOGETHER WITH AN ALCOHOL REPRESENTED BY THE FORMULA ROH WHEREIN R REPRESENTS AN AKYL GROUP HAVING 1 TO 4 CARBON ATOMS AT A TEMPERATURE OF 250*C. TO 400*C. UNDER PRESSURE. THE PRESENT PROCESS GIVES AN IMPROVED YIELD OF THE DESIRED PRODUCT AT A LOW COST AS COMPARED WITH THE PRIOR ART PROCESS. THE PROCESS CAN BE ADVANTAGEOUSLY MODIFIED. ONE MODIFICATION CONSISTS IN THE PROCESS OF A SPECIFIC CATALYST. ANOTHER MODIFICATION CONSISTS IN THE PROCESS IN WHICH AS LEAST A PART OF THE BY-PRODUCTS ARE RECYCLED IN THE REACTION SYSTEM. STILL ANOTHER MODIFICATION CONSISTS IN THE PROCESS IN WHICH THE REACTION IS CONDUCTED IN THE PRESENCE OF WATER, THE WATER BEING ADDED AT THE TIME OF INITIATION OF THE REACTION. SUCH MODIFICATIONS GIVE A FURTHER IMPROVED YIELD OF THE DESIRED PRODUCT.