公开(公告)号：US10112911B2

公开(公告)日：2018-10-30

申请号：US14410952

申请日：2013-06-28

Applicant: Abbvie Inc

Inventor： Artour Gomtsian ,  Tatyana Dekhtyar ,  Kristine E. Frank ,  Michael M. Friedman ,  Nathan Josephsohn ,  M-Akhteruzzaman Molla ,  Anil Vasudevan ,  Iok Chan Ng ,  Mikhail Chafeev

IPC: A61K31/495 ,  A61K31/497 ,  C07D241/04 ,  C07D241/26 ,  A61K31/498 ,  C07D413/04 ,  A61K31/496 ,  A61K31/517 ,  C07D487/04 ,  A61K31/519 ,  C07D405/14 ,  C07D403/14 ,  A61K31/499 ,  A61K31/5377 ,  A61K31/4985 ,  C07D401/14 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D417/04 ,  C07D241/44 ,  C07D471/04 ,  C07D317/66 ,  C07D231/40 ,  C07C335/30

Abstract: This disclosure relates to: (a) compounds and salts of formula (I), formula (II), formula (III), and formula (IV), that, inter alia, inhibit RSV infection and/or replication; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：US09447051B2

公开(公告)日：2016-09-20

申请号：US14379155

申请日：2013-02-15

Applicant: AbbVie inc.

Inventor： Tatyana Dekhtyar ,  Arthur Gomtsyan ,  M-Akhteruzzaman Molla ,  Anil Vasudevan ,  Iok Chan Ng ,  Mikhail Chafeev

IPC: C07D239/32 ,  A61K31/505 ,  C07D239/48 ,  C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D401/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14 ,  A61K45/06 ,  A61K31/506 ,  C07D413/14

CPC classification number: C07D239/48 ,  A61K31/505 ,  A61K31/506 ,  A61K45/06 ,  C07D239/32 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

Abstract: This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit RSV infection and/or replication; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：US20160068521A1

公开(公告)日：2016-03-10

申请号：US14786454

申请日：2014-04-22

Applicant: ABBVIE INC.

Inventor： Iok Chan Ng ,  M-akhteruzzaman Molla ,  Tami J. Pilot-Matias ,  Anil Vasudevan ,  Tatyana Dekhtyar ,  Artour Gomtsian ,  Katerina Sarris ,  Ana Aguirre ,  Mikhail Chafeev

IPC: C07D417/14 ,  A61K31/506 ,  A61K31/501 ,  A61K31/4178 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/427 ,  C07D403/14

CPC classification number: C07D417/14 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/506 ,  A61K45/06 ,  C07D403/14

Abstract: This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit RSV infection and/or replication; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Abstract translation: 本公开涉及：（a）其特别是抑制RSV感染和/或复制的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

公开(公告)号：US10233179B2

公开(公告)日：2019-03-19

申请号：US14786454

申请日：2014-04-22

Applicant: AbbVie Inc.

Inventor： Iok Chan Ng ,  M-akhteruzzaman Molla ,  Tami J. Pilot-Matias ,  Anil Vasudevan ,  Tatyana Dekhtyar ,  Artour Gomtsian ,  Kathy Sarris ,  Ana Aguirre ,  Mikhail Chafeev

IPC: C07D417/14 ,  C07D403/14 ,  A61K45/06 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/506

Abstract: This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit RSV infection and/or replication; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：US20150322045A1

公开(公告)日：2015-11-12

申请号：US14410952

申请日：2013-06-28

Applicant: Abbvie Inc.

Inventor： Artour Gomtsian ,  Tatyana Dekhtyar ,  Kristine E. Frank ,  Michael M. Friedman ,  Nathan Josephsohn ,  M-Akhteruzz Molla ,  Anil Vasudevan ,  Teresa Ng ,  Mikhail Chafeev

IPC: C07D403/04 ,  A61K31/498 ,  C07D413/04 ,  A61K31/496 ,  C07D417/04 ,  A61K31/517 ,  C07D487/04 ,  A61K31/519 ,  C07D405/14 ,  C07D403/14 ,  A61K31/499 ,  A61K31/5377 ,  C07D471/04 ,  A61K31/4985 ,  C07D401/14 ,  A61K31/497

CPC classification number: C07D241/26 ,  A61K31/496 ,  A61K31/497 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/499 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  C07C335/30 ,  C07D231/40 ,  C07D241/44 ,  C07D317/66 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04

Abstract: This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit RSV infection and/or replication; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Abstract translation: 本公开涉及：（a）其特别是抑制RSV感染和/或复制的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。