公开(公告)号：US20150305892A1

公开(公告)日：2015-10-29

申请号：US14262516

申请日：2014-04-25

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Syed Hossainy ,  Krishna Sudhir ,  John Stankus ,  Mikael Trollsas

IPC: A61F2/50 ,  A61L31/04 ,  A61L31/06 ,  A61F2/82 ,  A61L31/14

CPC classification number: A61F2/50 ,  A61F2/82 ,  A61F2210/0004 ,  A61F2210/0085 ,  A61L27/18 ,  A61L27/50 ,  A61L27/58 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/148 ,  A61L2300/624 ,  A61L2400/06 ,  A61L2400/12 ,  C08L67/04 ,  C08L71/02

Abstract: A bodily lumen, such as a blood vessel, can be treated by forming a structural support in situ within the bodily lumen. This can be done by ejecting a formulation that includes a polymer that solidifies over a period of time, such as due to DMSO exchange or photocrosslinking. This can also be done by cooling a formulation until it freezes in situ. The structural support can also be made from a plaque which is already present in the bodily lumen. The plaque can be compressed by a balloon catheter and cooled so that it hardens and thereby forms the structural support. The bodily lumen can also be treated using a preformed structural support made of ice, for example frozen isotonic saline, or a fast degrading polymer, such as PEG. The preformed support is created outside of the bodily lumen, and then transported on a catheter to the treatment zone.

Abstract translation: 可以通过在体腔内原位形成结构支架来治疗诸如血管的体腔。 这可以通过喷射包括在一段时间内固化的聚合物的制剂来实现，例如由于DMSO交换或光致交联。 这也可以通过冷却制剂直到其原位冻结来完成。 结构支撑物也可以由已经存在于体腔中的斑块制成。 斑块可以通过气囊导管压缩并冷却，使得其硬化并由此形成结构支撑。 还可以使用由冰制成的预制结构支撑物例如冷冻等渗盐水或快速降解聚合物例如PEG来处理身体腔。 预先形成的支撑体在体腔外部产生，然后在导管上运送到治疗区域。