公开(公告)号：US12121631B2

公开(公告)日：2024-10-22

申请号：US17527679

申请日：2021-11-16

申请人： Muffin Incorporated ,  Cook Biotech Incorporated

发明人： Michael C. Hiles ,  Chad E. Johnson ,  Neal E. Fearnot ,  Thomas Payne ,  Ronald Jankowski

IPC分类号： A61L27/50 ,  A61L27/24 ,  A61L27/36 ,  A61L27/38 ,  C12M1/00 ,  C12M1/12 ,  C12M3/00 ,  C12N5/00

CPC分类号： A61L27/50 ,  A61L27/24 ,  A61L27/3604 ,  A61L27/3633 ,  A61L27/3808 ,  A61L27/3826 ,  C12M21/08 ,  C12M23/06 ,  C12M23/34 ,  C12M25/14 ,  C12N5/0062 ,  A61L2430/02 ,  A61L2430/06 ,  A61L2430/26 ,  A61L2430/28 ,  A61L2430/30 ,  A61L2430/32 ,  A61L2430/34 ,  C12N2533/54

摘要： Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.

公开(公告)号：US12115280B2

公开(公告)日：2024-10-15

申请号：US17127281

申请日：2020-12-18

申请人： Edwards Lifesciences Corporation

发明人： Jeffrey S. Dove ,  Tara J. Tod

IPC分类号： A61L27/36 ,  A61L27/50 ,  A61L27/54

CPC分类号： A61L27/3687 ,  A61L27/50 ,  A61L27/54 ,  A61L2430/20 ,  A61L2430/40

摘要： Methods are provided herein for modifying antigenic carbohydrate epitopes within a xenographic bioprosthetic tissue by oxidation of vicinal diols to form aldehydes or acids and subsequence reductive amination of aldehydes to form stable secondary amines, or amidation or esterification of acids to form stable amides or esters. Advantageously, methods provided herein mitigate the antigenicity of the bioprosthetic tissue while leaving the overall tissue structure substantially undisturbed, and thereby enhance the durability, safety and performance of the bioprosthetic implant.

公开(公告)号：US12109330B2

公开(公告)日：2024-10-08

申请号：US17570549

申请日：2022-01-07

申请人： Ecole Polytechnique Federale de Lausanne (EPFL)

发明人： Amelie Barbara Hildegarde Beduer ,  Thomas Braschler ,  Philippe Renaud ,  Giorgio Pietramaggiori ,  Saja Scherer

IPC分类号： A61L27/56 ,  A61L15/42 ,  A61L27/22 ,  A61L27/36 ,  A61L27/38 ,  A61L27/50 ,  A61L27/52

CPC分类号： A61L27/56 ,  A61L27/227 ,  A61L27/3616 ,  A61L27/38 ,  A61L27/50 ,  A61L27/52 ,  A61L27/505

摘要： The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material impart a special behavior to the scaffold, which can be easily shaped and even highly reversibly compressed, so that in certain aspects it can, if needed, be injected, said capacity to be shaped being maintained over a high range of hydration conditions. A particular aspect of the invention relates, therefore, to the use of such scaffold material for the manufacturing of shapeable body implants, such as breast implants, to the shapeable body implants themselves as well as to non-invasive methods for using thereof in creating or reconstructing a three-dimensional volume in a subject's body part.

公开(公告)号：US20240325605A1

公开(公告)日：2024-10-03

申请号：US18623287

申请日：2024-04-01

申请人： BVW Holding AG

发明人： Lukas Bluecher ,  Michael Milbocker

IPC分类号： A61L27/50 ,  A61L27/36 ,  A61L27/38 ,  G03F7/20

CPC分类号： A61L27/50 ,  A61L27/3633 ,  A61L27/3886 ,  A61L2420/02 ,  G03F7/2002

摘要： Provided herein is a tissue scaffold that may include microstructure patterns on one or more surfaces that can modify the physical properties of the tissue scaffold. The microstructure patterns may be cell-directing across a larger spatial range than the prior art which uses chemically modified substrates. The present disclosure further includes tissue scaffold configured such that cells may infiltrate the tissue scaffold by responding to patterns of surface energy gradients on the tissue scaffold and the cells may not be constrained into patterns by physical means. As the cells proliferate, they associate and orient in response to long-range patterns to form confluent monolayers of cells while constructing functional macro-structure across the tissue scaffold surface.

公开(公告)号：US12102730B2

公开(公告)日：2024-10-01

申请号：US17352189

申请日：2021-06-18

申请人： University of Connecticut

发明人： Nikoo Saveh Shemshaki ,  Cato Laurencin

IPC分类号： A61L27/00 ,  A61L27/08 ,  A61L27/18 ,  A61L27/22 ,  A61L27/24 ,  A61L27/50

CPC分类号： A61L27/08 ,  A61L27/18 ,  A61L27/222 ,  A61L27/24 ,  A61L27/50 ,  A61L2400/12 ,  A61L2430/30

摘要： The disclosure is directed to scaffolds comprising nanofibers of graphene nanoplatelets and a biocompatible polymer, as well as methods for making and using such scaffolds.

公开(公告)号：US20240301114A1

公开(公告)日：2024-09-12

申请号：US18664001

申请日：2024-05-14

申请人： MITSUBISHI CHEMICAL CORPORATION

发明人： Haruhiko KUSAKA ,  Kazuki WAKABAYASHI ,  Masanori YAMAMOTO ,  Kazunao KUSANO ,  Hiroto ITO ,  Takashi KOMAYA ,  Teruhiko OHARA ,  Kentaro UCHINO ,  Haruo IIDUKA

IPC分类号： C08F290/06 ,  A61L27/18 ,  A61L27/50 ,  A61L29/06 ,  A61L29/14 ,  A61L31/06 ,  A61L31/14 ,  B32B27/40 ,  C07D493/04 ,  C08F20/36 ,  C08G18/44 ,  C08G18/66 ,  C08G18/67 ,  C08G18/75 ,  C08G64/02 ,  C08G64/16 ,  C08G64/30 ,  C08L75/04 ,  C09D175/04 ,  C09D175/14 ,  C09D175/16 ,  C09J175/04 ,  C09J175/14

CPC分类号： C08F290/067 ,  A61L27/18 ,  A61L27/50 ,  A61L27/507 ,  A61L29/06 ,  A61L29/14 ,  A61L31/06 ,  A61L31/14 ,  B32B27/40 ,  C07D493/04 ,  C08F20/36 ,  C08G18/44 ,  C08G18/664 ,  C08G18/672 ,  C08G18/755 ,  C08G64/02 ,  C08G64/0208 ,  C08G64/1608 ,  C08G64/302 ,  C08G64/305 ,  C08L75/04 ,  C09D175/04 ,  C09D175/14 ,  C09D175/16 ,  C09J175/04 ,  C09J175/14 ,  A61L2430/20

摘要： The present invention provides a novel polycarbonate diol and a polyurethane using the polycarbonate diol as raw materials. The novel polycarbonate diol produces polycarbonate diol-based polyurethane which has a high degree of hardness, superior abrasion resistance, and superior hydrophilicity, and is usable for an application such as a paint, a coating agent, a synthetic leather, an artificial leather, and a highly-functional elastomers, or the like. The present invention also provides an active-energy radiation curable polymer composition giving a cured film having a superior contamination resistance and high degree of hardness. The present invention is obtained, for example, by reacting specific two types of diols with diester carbonate in the presence of a transesterification catalyst being a compound using a metal of Group 1 or 2 on the periodic table. The present invention provides a polycarbonate diol wherein the metal content of the transesterification catalyst is 100 weight ppm or less, a polyurethane obtainable by using this polycarbonate diol and an active-energy radiation curable polymer composition containing the urethane(meth)acrylate oligomer which is obtained from the polycarbonate diol.

公开(公告)号：US12064534B2

公开(公告)日：2024-08-20

申请号：US17695964

申请日：2022-03-16

申请人： University of Massachusetts

发明人： Jie Song ,  Pingsheng Liu

IPC分类号： A61L27/44 ,  A61K38/18 ,  A61K38/30 ,  A61L27/14 ,  A61L27/18 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58

CPC分类号： A61L27/58 ,  A61K38/18 ,  A61K38/1875 ,  A61K38/30 ,  A61L27/14 ,  A61L27/18 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/414 ,  A61L2430/02

摘要： The invention provides a novel approach in which zwitterionic networks are used to sequester and deliver ionic biomolecules, such as proteins, without compromising their native conformation and bioactivity. Zwitterionic networks are designed to effectively retain and deliver ionic or polar biomolecules for guided tissue regeneration. The invention represents a conceptual advance and enables a novel strategy for the utilization of zwitterionic motifs as therapeutics delivery vehicles and tissue engineering scaffolds.

公开(公告)号：US12049570B2

公开(公告)日：2024-07-30

申请号：US17817772

申请日：2022-08-05

申请人： INDUSTRY ACADEMIC COOPERATION FOUNDATION, HALLYM UNIVERSITY

发明人： Chan Hum Park ,  Young Jin Lee ,  Olatunji Abolarin Ajiteru ,  Ok Joo Lee ,  Ji Seung Lee ,  Han Na Lee ,  Md Tipu Sultan ,  Jang Min Kim ,  Oh Jun Kwon ,  Ji Ye Kim ,  Ji Won Heo ,  Soon Hee Kim

IPC分类号： C09D151/08 ,  A61L27/22 ,  A61L27/26 ,  A61L27/50 ,  A61L27/52 ,  B33Y70/00 ,  C08F289/00 ,  C09D5/24 ,  C12N5/00 ,  C12N5/077 ,  C12N5/079

CPC分类号： C09D151/08 ,  A61L27/222 ,  A61L27/26 ,  A61L27/50 ,  A61L27/52 ,  B33Y70/00 ,  C08F289/00 ,  C09D5/24 ,  C12N5/0062 ,  C12N5/0068 ,  C12N5/0618 ,  C12N5/0658 ,  C12N2513/00 ,  C12N2533/30 ,  C12N2533/54 ,  C12N2539/00

摘要： The present disclosure relates to the composition and process for the production of an ultra-strong, biocompatible, electroconductive, and stretchable hydrogel, which comprises: a step (a) of physical or chemical modification of natural polymers e.g., preparation of silk nanofiber and double methacrylation of gelatin; a step (b) of graphene oxide (GO) carboxylation; a step (c) of carbodiimidation between methacrylated natural polymers of step (a) and carboxylated GO of step (b); and a step (d) of three dimensional (3D) bioprinting of step (c) with/without silk nanofiber. It was found that these steps in this disclosure give rise to a biocompatible hydrogel with high mechanical strength in the range of load-bearing soft tissue such as tendon and heart as opposed to conventional hydrogels.

公开(公告)号：US12005155B2

公开(公告)日：2024-06-11

申请号：US17113635

申请日：2020-12-07

申请人： Warsaw Orthopedic, Inc.

发明人： James Davidson ,  William Rezach ,  Rodney Ballard

IPC分类号： A61L31/02 ,  A61L27/04 ,  A61L27/50 ,  A61L31/14 ,  C22C27/00 ,  C22C27/04

CPC分类号： A61L27/047 ,  A61L27/50 ,  A61L31/022 ,  A61L31/14 ,  C22C27/00 ,  C22C27/04 ,  A61L2430/12 ,  A61L2430/22 ,  A61L2430/38

摘要： Medical devices, such as implants, having a high-modulus alloy. The alloy includes a biocompatible refractory-metal-based alloy having multiple refractory metals. The alloy has an elastic modulus above about 300 GPa. The alloy comprises 30-35% tungsten, 60% molybdenum, and 5-10% niobium. The alloy is absent of rhenium.

公开(公告)号：US11993442B2

公开(公告)日：2024-05-28

申请号：US18198417

申请日：2023-05-17

申请人： ETS Technology Holdings LLC

发明人： Steven B. Jung

IPC分类号： B65D77/04 ,  A61F2/00 ,  A61F13/00 ,  A61L27/10 ,  A61L27/50 ,  B65D5/50 ,  B65D25/10 ,  B65D75/22 ,  B65D81/107 ,  B65D81/133 ,  B65D85/07 ,  B65D81/113

CPC分类号： B65D77/0406 ,  A61F2/0095 ,  A61F13/00072 ,  A61L27/10 ,  A61L27/50 ,  B65D25/10 ,  B65D75/22 ,  B65D81/1075 ,  B65D81/133 ,  B65D85/07 ,  B65D5/503 ,  B65D81/113

摘要： A more robust packaging structure for maintaining the integrity of compressible biologically active materials during storage and especially during transportation is provided. These containers protect the materials from shock, vibration, deformation, or separation from agitation. The compressible materials may be in the form of synthetic fibers, and may include a composite of fibers and beads or granules. Suitable materials that may benefit from such a robust packaging structure include synthetic materials that comprise a biologically active ceramic or glass.