公开(公告)号：US11986561B2

公开(公告)日：2024-05-21

申请号：US17499221

申请日：2021-10-12

申请人： THE PENN STATE RESEARCH FOUNDATION ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Jian Yang ,  Kytai T. Nguyen ,  Zhiwei Xie

IPC分类号： A61L15/22 ,  A61L15/26 ,  A61L15/28 ,  A61L15/42 ,  A61L15/44 ,  A61L15/64 ,  A61L31/04 ,  A61L31/06 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  C08L67/04

CPC分类号： A61L15/225 ,  A61L15/26 ,  A61L15/28 ,  A61L15/425 ,  A61L15/44 ,  A61L15/64 ,  A61L31/042 ,  A61L31/06 ,  A61L31/129 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  C08L67/04 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/414 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2300/624 ,  A61L31/06 ,  C08L71/02 ,  A61L31/042 ,  C08L1/26 ,  A61L31/042 ,  C08L5/08 ,  A61L31/129 ,  C08L67/04 ,  A61L31/129 ,  C08L71/02 ,  A61L31/129 ,  C08L1/26 ,  A61L31/129 ,  C08L5/08 ,  A61L15/28 ,  C08L5/08 ,  A61L15/28 ,  C08L1/26 ,  A61L15/26 ,  C08L71/02

摘要： In one aspect, compositions and wound dressings are described herein. In some embodiments, a composition or wound dressing described herein comprises a mesh formed from a plurality of biodegradable polymer fibers; a first active agent dispersed in the biodegradable polymer fibers; a plurality of biodegradable polymer particles disposed in the mesh; and a second active agent dispersed in the biodegradable polymer particles. The particles can be disposed within the interiors of the fibers of the mesh or between the fibers of the mesh. In another aspect, a composition or wound dressing described herein comprises a first perforated mesh formed from a first plurality of biodegradable polymer fibers; and a second perforated mesh formed from a second plurality of biodegradable polymer fibers, wherein the second perforated mesh is disposed on the first perforated mesh in a stacked configuration and the first and second perforated meshes have different degrees of perforation.

公开(公告)号：US11965269B2

公开(公告)日：2024-04-23

申请号：US17448819

申请日：2021-09-24

申请人： Julianne Holloway ,  Kevin Tindell

发明人： Julianne Holloway ,  Kevin Tindell

IPC分类号： D01D5/00 ,  A61L27/04 ,  A61L27/44 ,  A61L27/48 ,  D01F1/10 ,  D04H3/015 ,  D04H3/016 ,  D04H3/04 ,  A61L27/54 ,  B29C70/16

CPC分类号： D01D5/0092 ,  A61L27/04 ,  A61L27/446 ,  A61L27/48 ,  D01D5/0015 ,  D01D5/0069 ,  D01D5/0076 ,  D01F1/10 ,  D04H3/015 ,  D04H3/016 ,  D04H3/04 ,  A61L27/54 ,  A61L2300/44 ,  A61L2300/624 ,  A61L2400/12 ,  A61L2430/02 ,  A61L2430/06 ,  B29C70/16

摘要： Described are fibrous materials comprising a plurality of fibers having a longitudinal alignment gradient and/or a longitudinal composition gradient. Also described are methods of preparing the fibrous materials thereof and methods of treating organ or tissue damage with the fibrous materials.

公开(公告)号：US20230256136A1

公开(公告)日：2023-08-17

申请号：US18018275

申请日：2021-07-28

申请人： University of Georgia Research Foundation, Inc.

发明人： Hitesh HANDA ,  Sama GHALEI

IPC分类号： A61L26/00

CPC分类号： A61L26/0066 ,  A61L26/008 ,  A61L26/0085 ,  A61L26/0047 ,  A61L2300/114 ,  A61L2300/406 ,  A61L2300/624 ,  A61L2400/12 ,  B82Y5/00

摘要： Described herein are biocompatible materials that include a nitric oxide (NO) donor embedded in silk fibroin nanoparticles. In one aspect, the nitric oxide donor is present in the hydrophobic core of the silk fibroin nanoparticles such that the nitric oxide donor is encapsulated. The biocompatible materials described herein serve as a biocompatible and inexpensive nitric oxide delivery platform that provide sustained release of nitric oxide. The biocompatible materials are non-toxic and can be used in biomedical applications such as wound healing, where a combination of therapeutic and antibacterial properties of silk and nitric oxide are desired. Additionally, described herein are methods of making the biocompatible materials.

公开(公告)号：US20190193109A1

公开(公告)日：2019-06-27

申请号：US16290109

申请日：2019-03-01

申请人： Nanocopoeia, Inc.

发明人： Robert A. Hoerr ,  John V. Carlson

IPC分类号： B05D1/06 ,  B05D1/36 ,  A61L27/34 ,  B05D7/00 ,  B05D1/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  B05B5/025 ,  B05D1/04

CPC分类号： B05D1/06 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/602 ,  A61L2300/624 ,  A61L2400/12 ,  A61L2420/02 ,  A61L2420/06 ,  B05B5/025 ,  B05B5/03 ,  B05B5/08 ,  B05B7/061 ,  B05D1/04 ,  B05D1/34 ,  B05D1/36 ,  B05D7/54 ,  B05D2258/00 ,  B05D2451/00 ,  B05D2401/32

摘要： A nanoparticle coated hydrogel may be formed by a method of electrospraying nanoparticles on to a surface includes providing a drug and polymer combination in solvent to an inner capillary of a coaxial dual capillary spray nozzle. A coating with a drug that releases over time may be provided. Open and closed matrixes may be selectively formed to help modify time release periods.

公开(公告)号：US20180228937A1

公开(公告)日：2018-08-16

申请号：US15835295

申请日：2017-12-07

申请人： The Regents of the University of California

发明人： Sungho JIN ,  Seunghan OH

IPC分类号： A61L27/30 ,  A61L27/54 ,  A61L27/18 ,  C25D11/02 ,  A61L27/14 ,  A61L27/10 ,  C25D7/00 ,  C23C30/00 ,  C23C28/00 ,  A61L27/16 ,  A61L27/38

CPC分类号： A61L27/306 ,  A61L27/10 ,  A61L27/14 ,  A61L27/16 ,  A61L27/18 ,  A61L27/30 ,  A61L27/3839 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/254 ,  A61L2300/256 ,  A61L2300/258 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/43 ,  A61L2300/624 ,  A61L2400/12 ,  A61L2400/18 ,  C23C28/32 ,  C23C28/345 ,  C23C30/00 ,  C25D7/006 ,  C25D11/02 ,  C25D11/045 ,  C25D11/26

摘要： The present invention provides articles of manufacture comprising biocompatible nanostructures comprising significantly increased surface area for, e.g., organ, tissue and/or cell growth, e.g., for bone, tooth, kidney or liver growth, and uses thereof, e.g., for in vitro testing of drugs, chemicals or toxins, or as in vivo implants, including their use in making and using artificial tissues and organs, and related, diagnostic, screening, research and development and therapeutic uses, e.g., as drug delivery devices. The present invention provides biocompatible nanostructures with significantly increased surface area, such as with nanotube and nanopore array on the surface of metallic, ceramic, or polymer materials for enhanced cell and bone growth, for in vitro and in vivo testing, cleansing reaction, implants and therapeutics. The present invention provides optically transparent or translucent cell-culturing substrates. The present invention provides biocompatible and cell-growth-enhancing culture substrates comprising elastically compliant protruding nanostructure substrates coated with Ti, TiO2 or related metal and metal oxide films.

公开(公告)号：US20180064539A1

公开(公告)日：2018-03-08

申请号：US15700931

申请日：2017-09-11

申请人： PURDUE RESEARCH FOUNDATION

发明人： Thomas J. WEBSTER ,  Venu PERLA

IPC分类号： A61F2/30 ,  A61L27/34 ,  C25D11/02 ,  C25D5/34 ,  A61L31/16 ,  A61L31/02 ,  A61B17/08 ,  A61L27/54 ,  A61L27/04 ,  A61L27/56 ,  A61L27/50 ,  A61L27/32 ,  A61K9/00

CPC分类号： A61F2/30771 ,  A61B17/08 ,  A61F2/30 ,  A61F2002/30011 ,  A61F2002/30062 ,  A61F2002/30064 ,  A61F2002/3084 ,  A61F2002/3092 ,  A61F2002/30929 ,  A61F2002/3093 ,  A61F2002/30968 ,  A61F2310/00023 ,  A61F2310/0097 ,  A61F2310/00982 ,  A61K9/0024 ,  A61K9/0092 ,  A61L27/04 ,  A61L27/32 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L31/022 ,  A61L31/16 ,  A61L2300/414 ,  A61L2300/604 ,  A61L2300/624 ,  A61L2400/12 ,  A61L2400/18 ,  A61L2430/02 ,  C25D5/34 ,  C25D11/02 ,  Y10T428/24355

摘要： One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.

公开(公告)号：US09878073B2

公开(公告)日：2018-01-30

申请号：US15133353

申请日：2016-04-20

申请人： HEART BIOTECH LIMITED

发明人： Magdi Habib Yacoub ,  Ibrahim El-Sherbiny

IPC分类号： A61F2/82 ,  A61L31/14 ,  A61L31/02 ,  A61L31/10 ,  A61L31/16 ,  A61F2/958 ,  A61L31/04 ,  A61L31/06

CPC分类号： A61L31/148 ,  A61F2/82 ,  A61F2/958 ,  A61L31/022 ,  A61L31/048 ,  A61L31/06 ,  A61L31/10 ,  A61L31/145 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/114 ,  A61L2300/416 ,  A61L2300/624 ,  A61L2420/02 ,  A61L2420/06 ,  C08L67/04

摘要： The invention involves bioresorbable stents which elute nitric oxide (NO). The stent is comprised of three main key design elements: a bioresorbable scaffold, a bioresorbable polymeric coating layer(s), and NO-releasing nanoparticles incorporated in the bioresorbable polymeric coating layer, and optionally also in the scaffold. The NO-releasing nanoparticles are made of nontoxic biocompatible and biodegradable materials; for example a chitosan polymer and optionally a sugar.

公开(公告)号：US20170319446A1

公开(公告)日：2017-11-09

申请号：US15527479

申请日：2015-11-10

申请人： NanotecMARIN GmbH

发明人： Werner Ernst Ludwig Georg MÜLLER

IPC分类号： A61K8/24 ,  A61K8/02 ,  A61K8/67 ,  A61Q19/08

CPC分类号： A61K8/24 ,  A61K8/0283 ,  A61K8/671 ,  A61K2800/413 ,  A61L27/12 ,  A61L2300/624 ,  A61L2400/12 ,  A61L2430/02 ,  A61Q19/08

摘要： This invention concerns a calcium polyphosphate material consisting of amorphous nanoparticles with a diameter of approximately between about 45 nm to about 0.25 μm that displays a considerable hardness (elastic modulus) of about 1.3 GPa. The inventive noncrystalline and biodegradable material that is produced under mild conditions, at room temperature, is morphogenetically active and preferably induces bone formation and the expression of the marker gene for osteoblast activity, alkaline phosphatase. In a preferred aspect, the invention concerns a method for producing amorphous retinol/calcium-polyphosphate nanospheres (retinol/aCa-polyP-NS) that show several unexpected properties and can be used in the treatment or prophylaxis of a variety of dermatological conditions, including photoaging.

公开(公告)号：US20170172218A1

公开(公告)日：2017-06-22

申请号：US14977064

申请日：2015-12-21

申请人： Misbah Khan

发明人： Misbah Khan

IPC分类号： A41B9/12 ,  A61L15/26 ,  A61L15/46 ,  A61L15/40 ,  A61L15/20 ,  A61L15/44 ,  A61L15/58 ,  A61L15/18

CPC分类号： A41B9/12 ,  A41B2400/36 ,  A41B2400/60 ,  A41D27/12 ,  A41D27/13 ,  A61F13/14 ,  A61F13/15 ,  A61F13/47 ,  A61F13/8405 ,  A61L15/40 ,  A61L15/46 ,  A61L2300/30 ,  A61L2300/404 ,  A61L2300/624 ,  A61L2400/12

摘要： Body liners for absorbing sweat and masking or adsorbing odors occurring in breast, panty, and underarm areas are sized according to area and have mesh top surface, cotton central layer and bottom surface. The mesh top surface is coated for silkiness, the central layer impregnated with plant extracts for anti-inflammatory properties, fragrance, and odor masking. Liners may line garments, or have adhesive for adhering to skin.

公开(公告)号：US09636356B2

公开(公告)日：2017-05-02

申请号：US14421086

申请日：2013-07-05

申请人： JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH

发明人： Jayanta Haldar ,  Divakara Siva Sathyanarayana Murthy Uppu ,  Padma Akkapeddi ,  Goutham Belagula Manjunath

IPC分类号： C08F220/52 ,  A61K31/787 ,  C08F210/10 ,  A61K9/14 ,  C08F222/40 ,  C09D123/22 ,  C09D135/00 ,  C08L23/22 ,  C08L35/00 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  C08F8/02 ,  C08F8/12 ,  C08F8/30 ,  C08F8/32 ,  C08F8/44 ,  C08F8/48 ,  B82Y40/00

CPC分类号： A61K31/787 ,  A61K9/14 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/404 ,  A61L2300/624 ,  A61L2400/12 ,  B82Y40/00 ,  C08F8/02 ,  C08F8/12 ,  C08F8/30 ,  C08F8/32 ,  C08F8/44 ,  C08F8/48 ,  C08F210/10 ,  C08F220/52 ,  C08F222/40 ,  C08F2800/10 ,  C08L23/22 ,  C08L35/00 ,  C09D123/22 ,  C09D135/00 ,  Y02A50/473 ,  C08F222/06 ,  C08F2222/406

摘要： The present disclosure relates to the development of antibacterial compounds and their nanoparticle compositions. Methods of making the compounds and their nanoparticle compositions, their use as medicament for the treatment of bacterial infection and also for suppressing potentially harmful inflammation are disclosed.