公开(公告)号：US20140017200A1

公开(公告)日：2014-01-16

申请号：US13941759

申请日：2013-07-15

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Eugene T. Michal ,  Olof Mikael Trollsas ,  Shubhayu Basu

IPC: A61K47/34

CPC classification number: A61K47/34 ,  A61K9/0024 ,  A61K9/06 ,  A61K35/12 ,  A61K38/00 ,  A61L27/26 ,  A61L27/38 ,  A61L27/50 ,  A61K2300/00

Abstract: Compositions, methods of manufacture and methods of treatment for post-myocardial infarction are herein disclosed. In some embodiments, the composition includes at least two components. In one embodiment, a first component can include a first functionalized polymer and a substance having at least one cell adhesion site combined in a first buffer at a pH of approximately 6.5. A second component can include a second buffer in a pH of between about 7.5 and 9.0. A second functionalized polymer can be included in the first or second component. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition(s) of the present invention can be delivered by a dual bore injection device to a treatment area, such as a post-myocardial infarct region.

Abstract translation: 本文公开了组合物，制造方法和心肌梗死后治疗方法。 在一些实施方案中，组合物包含至少两种组分。 在一个实施方案中，第一组分可以包括第一官能化聚合物和具有至少一个细胞粘附位点的物质，其在约6.5的pH下在第一缓冲液中组合。 第二组分可以包括pH在约7.5和9.0之间的第二缓冲液。 第二官能化聚合物可以包括在第一或第二组分中。 在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。 在一些实施方案中，本发明的组合物可以通过双孔注射装置递送至治疗区域，例如心肌梗死后区域。