Device for Revitalizing a Biocompatible Tissue

    公开(公告)号:US20240252722A1

    公开(公告)日:2024-08-01

    申请号:US18602785

    申请日:2024-03-12

    IPC分类号: A61L27/36 A61L27/38

    摘要: A device adapted to make one or more holes on a surface of a biocompatible tissue for revitalizing the tissue, the device including one or more conductive needles arranged on a mechanical stand, the mechanical stand having a support that mainly extends along a longitudinal extension axis configured to be introduced into a cavity defined by an essentially tubular-shaped biocompatible tissue, the one or more conductive needles being directed towards an outer and/or inner surface of the support such as to make one or more holes spread out on at least one generatrixes of the tissue, the one or more holes being made with a depth which occupies at least a part of a thickness of the tissue.

    MEANS AND METHODS FOR IMPLANTING CELLS SECRETING A THERAPEUTIC COMPOUND

    公开(公告)号:US20240009437A1

    公开(公告)日:2024-01-11

    申请号:US18452096

    申请日:2023-08-18

    摘要: A device for implantation into a mammalian host has a dialysis tube with a lumen and a dialysis membrane enclosing the lumen. The dialysis tube has an outer diameter of 20 μm to 600 μm. The dialysis membrane has a molecular weight cutoff of from 25 kDa to 150 kDa and has a material composition of at least one of the following: polyethersulfone, polyarylethersulfone, polyethylene, polytetrafluoroethylene, polyvinylidene fluoride, and polypropylene. A therapeutic composition is disposed within the lumen and has cells that secrete a therapeutic compound. A matrix material embeds the cells. The matrix material is one or more of alginate, collagen, fibrin, extracellular matrix material, synthetic hydrogel, and acrylate. Also disclosed are a method of producing a device for implantation, a port system, and a cell secreting a therapeutic compound for use in treating disease by implantation of the cells in a device for implantation.